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IGHE: immunoglobulin heavy constant epsilon

1 protein, 3 patents, 6 drugs, 160 trials, 10,057 NIH grants and 68,531 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIGHEHGNC
Nameimmunoglobulin heavy constant epsilonHGNC
NCBI Gene ID3497NCBI Gene
HGNC IDHGNC:5522HGNC
EnsemblENSG00000211891NCBI Gene
AliasesIgENCBI Gene
TypeotherNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P01854Immunoglobulin heavy constant epsilon54635Ensembl, HGNCUniProt

Patents 3

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4791787 A22026-08-194670P01854Espacenet
JP 2026064000 A2026-04-1362P01854Espacenet
WO 2025217398 A12025-10-1649P01854Espacenet

Drugs 6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AL-901CHEMBL2109455Ig epsilon chain C region inhibitorINHIBITORChEMBL
LIGELIZUMABCHEMBL2109457Ig epsilon chain C region inhibitorINHIBITORChEMBL
MEDI-4212CHEMBL2109452Ig epsilon chain C region inhibitorINHIBITORChEMBL
OMALIZUMABCHEMBL1201589Ig epsilon chain C region inhibitorINHIBITORChEMBL
QUILIZUMABCHEMBL2109456Ig epsilon chain C region inhibitorINHIBITORChEMBL
TALIZUMABCHEMBL2107888Ig epsilon chain C region inhibitorINHIBITORChEMBL

Trials 160

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07425639OMALIZUMABClinicalTrials.gov
NCT07073404OMALIZUMABClinicalTrials.gov
NCT07059091OMALIZUMABPHASE2ClinicalTrials.gov
NCT06943534OMALIZUMABPHASE2ClinicalTrials.gov
NCT06934200OMALIZUMABPHASE2ClinicalTrials.gov
NCT06869382OMALIZUMABPHASE4ClinicalTrials.gov
NCT06771934OMALIZUMABClinicalTrials.gov
NCT06617754OMALIZUMABClinicalTrials.gov
NCT06456450OMALIZUMABClinicalTrials.gov
NCT06365879OMALIZUMABPHASE3ClinicalTrials.gov

NIH grants 10057

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R37AI020565IgE antibodies to the mammalian oligosaccharide galactose-alpha-1, 3-galactose (alpha-gal): immunology, epidemiology and relevance to allergic and inflammatory disease1052,025NIH's project files
U19AI104209Integrated Genomic and Functional Studies of Immunotherapy for Multi-Food Allergy802,025NIH's project files
R01AI077653Antigenic determinants of asthma-associated allergens for design of immunotherapy602,025NIH's project files
P30ES009089Center for Environmental Health in Northern Manhattan582,025NIH's project files
U19AI070235Epithelial Genes in Allergic Inflammation582,025NIH's project files
T32AI007512Molecular Basis of Allergic and Immunologic Disease522,025NIH's project files
T32HL007427SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASES492,025NIH's project files
T32AI007062Research Training in Allergy and Clinical Immunology452,025NIH's project files
P30CA008748Cancer Center Support Grant442,025NIH's project files
ZIAAI000646Transgenic Animal Models Of Human Immune Defects442,025NIH's project files

Papers 68531

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827467PubTator, text miningPubMed
42826257PubTator, text miningPubMed
42825850PubTator, text miningPubMed
42825435PubTator, text miningPubMed
42825053PubTator, text miningPubMed
42824523PubTator, text miningPubMed
42823651PubTator, text miningPubMed
42822051PubTator, text miningPubMed
42821054PubTator, text miningPubMed
42819305PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license