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APP: amyloid beta precursor protein

1 protein, 352 patents, 13 drugs, 124 trials, 28,210 NIH grants and 109,783 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolAPPHGNC
Nameamyloid beta precursor proteinHGNC
NCBI Gene ID351NCBI Gene
HGNC IDHGNC:620HGNC
EnsemblENSG00000142192NCBI Gene
AliasesAAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, alpha-sAPP, preA4NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P05067Amyloid-beta precursor protein770255Ensembl, GeneID, HGNCUniProt

Patents 352

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026086590 A2026-05-261P05067Espacenet
EP 4716540 A12026-04-0117P05067Espacenet
EP 4716542 A12026-04-0144P05067Espacenet
JP 2026503664 A2026-01-2985P05067Espacenet
JP 2026004568 A2026-01-1437274P05067Espacenet
WO 2025260029 A12025-12-1829P05067Espacenet
WO 2025245381 A12025-11-27117P05067Espacenet
EP 4650780 A22025-11-193241P05067Espacenet
EP 4640849 A22025-10-29399P05067Espacenet
EP 4641201 A22025-10-292816P05067Espacenet

Drugs 13

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ADUCANUMABCHEMBL3039540Amyloid-beta A4 protein binding agentBINDING AGENTChEMBL
AMILOMOTIDECHEMBL2108328Amyloid-beta A4 protein vaccine antigenVACCINE ANTIGENChEMBL
BAPINEUZUMABCHEMBL2108576Amyloid-beta A4 protein binding agentBINDING AGENTChEMBL
CRENEZUMABCHEMBL1743004Amyloid-beta A4 protein inhibitorINHIBITORChEMBL
DONANEMABCHEMBL4297245Amyloid-beta A4 protein disrupting agentDISRUPTING AGENTChEMBL
GANTENERUMABCHEMBL1743025Amyloid-beta A4 protein binding agentBINDING AGENTChEMBL
GSK933776CHEMBL2109300Amyloid-beta A4 protein binding agentBINDING AGENTChEMBL
LECANEMABCHEMBL3833321Amyloid-beta A4 protein inhibitorINHIBITORChEMBL
PONEZUMABCHEMBL1743058Amyloid-beta A4 protein binding agentBINDING AGENTChEMBL
SOLANEZUMABCHEMBL1743072Amyloid-beta A4 protein binding agentBINDING AGENTChEMBL

Trials 124

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07604896LECANEMABPHASE4ClinicalTrials.gov
NCT07602582DONANEMABPHASE3ClinicalTrials.gov
NCT07589595DONANEMABPHASE2ClinicalTrials.gov
NCT07571161DONANEMABPHASE3ClinicalTrials.gov
NCT07544953LECANEMABClinicalTrials.gov
NCT07505095LECANEMABClinicalTrials.gov
NCT07167966DONANEMABPHASE2ClinicalTrials.gov
NCT07152418LECANEMABClinicalTrials.gov
NCT07034222LECANEMABPHASE4ClinicalTrials.gov
NCT06957418DONANEMABPHASE2ClinicalTrials.gov

NIH grants 28210

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study4712,025NIH's project files
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)3702,025NIH's project files
P30AG066444Alzheimer's Disease Research Center2752,025NIH's project files
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions2282,025NIH's project files
U19AG032438Bridge Funding for Dominantly Inherited Alzheimer Network2122,025NIH's project files
P01AG036694Impact of Amyloid and Tau on the Aging Brain: The Harvard Aging Brain Study1942,025NIH's project files
U19AG024904Alzheimer's Disease Neuroimaging Initiative (ADNI4)1852,025NIH's project files
P30AG062715Wisconsin Alzheimer's Disease Research Center1782,025NIH's project files
P30AG062421Massachusetts Alzheimer's Disease Research Center (MADRC)1772,025NIH's project files
P30AG072975Rush Alzheimer's Disease Research Center1522,025NIH's project files

Papers 109783

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826722PubTator, text miningPubMed
42826515PubTator, text miningPubMed
42825974PubTator, text miningPubMed
42824999PubTator, text miningPubMed
42824632PubTator, text miningPubMed
42823731PubTator, text miningPubMed
42822554PubTator, text miningPubMed
42821845PubTator, text miningPubMed
42820286PubTator, text miningPubMed
42819539PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license