Gene · 353376
TICAM2: TIR domain containing adaptor molecule 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TICAM2: TIR domain containing adaptor molecule 2. Genes, record 353376. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/353376
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q86XR7 | TIR domain-containing adapter molecule 2 | 235 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents24
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 13935 | Q86XR7 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 13935 | Q86XR7 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 89182 | Q86XR7 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 4817 | Q86XR7 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 192153 | Q86XR7 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 11562 | Q86XR7 | Espacenet |
| US 10918740 B2 | 2021-02-16 | 9417 | Q86XR7 | Espacenet |
| US 10869935 B2 | 2020-12-22 | 9417 | Q86XR7 | Espacenet |
| US 10293058 B2 | 2019-05-21 | 9417 | Q86XR7 | Espacenet |
| JP 2018517674 A | 2018-07-05 | 9985 | Q86XR7 | Espacenet |
1 to 10 of 24
See all 24 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,036
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TICAM2 papers | Newest fiscal year |
|---|---|---|---|
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 15 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 4 | 2025 |
| P30DK084567 | Mayo Center for Cell Signaling in Gastroenterology | 3 | 2025 |
| P30EY011373 | CWRU NEI Vision Center Core Grant | 3 | 2025 |
| R01AA017986 | Heat shock protein 90 in alcoholic liver disease: targeting macrophage Function | 3 | 2025 |
| P20GM103423 | The Maine Biomedical Research Network (INBRE) | 2 | 2025 |
| P30AG028740 | University of Florida Older Americans Independence Center (OAIC) | 2 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 2 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 2 | 2025 |
| P30DK017047 | Diabetes Research Center | 2 | 2025 |
1 to 10 of 1,036Source NIH's project files
See all 1,036 nih grantsPapers1,547
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| TRAM promotes Toll-like-receptor-free myddosome signal transduction. | Nature | 2026 | 42778610 | PubTator, text mining | PubMed |
| Genome-wide interactions with cadmium exposure in dysglycemia: Populational effects and molecular insights. | J Hazard Mater | 2026 | 42748818 | PubTator, text mining | PubMed |
| MyD88-Family Adaptors: Compartmentalised Signalling and Non-Immune Functions. | Immunology | 2026 | 42552630 | PubTator, text mining | PubMed |
| Toll-like receptor 4 signaling links cytoskeletal remodeling to lipid accumulation in macrophages. | Inflamm Regen | 2026 | 42401987 | PubTator, text mining | PubMed |
| Evolocumab Alters Transcriptomic Signatures and Identifies Inflammatory Biomarkers in Brain-Heart Syndrome with Coronary Heart Disease History. | Int J Gen Med | 2026 | 42205681 | PubTator, text mining | PubMed |
| Genistein alleviates skin inflammation in atopic dermatitis by inhibiting mast cell degranulation through toll-like receptor. | Phytomedicine | 2026 | 42184496 | PubTator, text mining | PubMed |
| Translating Fibrosis to Malignancy: Biomarkers and Therapeutic Opportunities in Liver Fibrosis and Hepatocellular Carcinoma. | Med Sci (Basel) | 2026 | 41892825 | PubTator, text mining | PubMed |
| The interplay of dietary sugar, chronic inflammation, and bladder cancer: mechanistic insights, evidence, and prevention strategies. | Front Immunol | 2026 | 41737225 | PubTator, text mining | PubMed |
| Role of autophagy in antiviral innate immunity. | Cell Mol Biol Lett | 2026 | 41735833 | PubTator, text mining | PubMed |
| Nanoparticles Targeting the Tumor Microenvironment for the Treatment of Osteosarcoma: Recent Progress and Perspectives. | Int J Nanomedicine | 2026 | 41725887 | PubTator, text mining | PubMed |
1 to 10 of 1,547
See all 1,547 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/353376
GET https://conductscience.org/api/genes/v1/353376/patents?page=2