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Gene · 353376

TICAM2: TIR domain containing adaptor molecule 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TICAM2: TIR domain containing adaptor molecule 2. Genes, record 353376. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/353376

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Gene

Symbol
TICAM2
HGNC
Name
TIR domain containing adaptor molecule 2
HGNC
NCBI Gene ID
353376
NCBI Gene
HGNC ID
HGNC:21354
HGNC
Ensembl
ENSG00000243414
NCBI Gene
Aliases
MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q86XR7TIR domain-containing adapter molecule 22353Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1913935Q86XR7Espacenet
JP 2025517970 A2025-06-1213935Q86XR7Espacenet
US 11446398 B22022-09-2089182Q86XR7Espacenet
US 11400116 B22022-08-024817Q86XR7Espacenet
JP 2022524081 A2022-04-27192153Q86XR7Espacenet
US 11078247 B22021-08-0311562Q86XR7Espacenet
US 10918740 B22021-02-169417Q86XR7Espacenet
US 10869935 B22020-12-229417Q86XR7Espacenet
US 10293058 B22019-05-219417Q86XR7Espacenet
JP 2018517674 A2018-07-059985Q86XR7Espacenet

1 to 10 of 24

See all 24 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,036

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTICAM2 papersNewest fiscal year
P30DK034854Integrated Epithelial and Muscosal Biology152025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital42025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology32025
P30EY011373CWRU NEI Vision Center Core Grant32025
R01AA017986Heat shock protein 90 in alcoholic liver disease: targeting macrophage Function32025
P20GM103423The Maine Biomedical Research Network (INBRE)22025
P30AG028740University of Florida Older Americans Independence Center (OAIC)22025
P30CA006927Comprehensive Cancer Center Program at Fox Chase22025
P30CA016672Cancer Center Support Grant22025
P30DK017047Diabetes Research Center22025

1 to 10 of 1,036Source NIH's project files

See all 1,036 nih grants

Papers1,547

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
TRAM promotes Toll-like-receptor-free myddosome signal transduction.Nature202642778610PubTator, text miningPubMed
Genome-wide interactions with cadmium exposure in dysglycemia: Populational effects and molecular insights.J Hazard Mater202642748818PubTator, text miningPubMed
MyD88-Family Adaptors: Compartmentalised Signalling and Non-Immune Functions.Immunology202642552630PubTator, text miningPubMed
Toll-like receptor 4 signaling links cytoskeletal remodeling to lipid accumulation in macrophages.Inflamm Regen202642401987PubTator, text miningPubMed
Evolocumab Alters Transcriptomic Signatures and Identifies Inflammatory Biomarkers in Brain-Heart Syndrome with Coronary Heart Disease History.Int J Gen Med202642205681PubTator, text miningPubMed
Genistein alleviates skin inflammation in atopic dermatitis by inhibiting mast cell degranulation through toll-like receptor.Phytomedicine202642184496PubTator, text miningPubMed
Translating Fibrosis to Malignancy: Biomarkers and Therapeutic Opportunities in Liver Fibrosis and Hepatocellular Carcinoma.Med Sci (Basel)202641892825PubTator, text miningPubMed
The interplay of dietary sugar, chronic inflammation, and bladder cancer: mechanistic insights, evidence, and prevention strategies.Front Immunol202641737225PubTator, text miningPubMed
Role of autophagy in antiviral innate immunity.Cell Mol Biol Lett202641735833PubTator, text miningPubMed
Nanoparticles Targeting the Tumor Microenvironment for the Treatment of Osteosarcoma: Recent Progress and Perspectives.Int J Nanomedicine202641725887PubTator, text miningPubMed

1 to 10 of 1,547

See all 1,547 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/353376

GET https://conductscience.org/api/genes/v1/353376/patents?page=2