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IKBKB: inhibitor of nuclear factor kappa B kinase subunit beta

1 protein, 94 patents, 7 drugs, 28 trials, 6,944 NIH grants and 13,054 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIKBKBHGNC
Nameinhibitor of nuclear factor kappa B kinase subunit betaHGNC
NCBI Gene ID3551NCBI Gene
HGNC IDHGNC:5960HGNC
EnsemblENSG00000104365NCBI Gene
AliasesIKK-2, IKK-beta, IKK2, IKKB, IMD15, IMD15A, IMD15B, NFKBIKBNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O14920Inhibitor of nuclear factor kappa-B kinase subunit beta7565Ensembl, GeneID, HGNCUniProt

Patents 94

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4778529 A12026-07-221O14920Espacenet
JP 2026004568 A2026-01-1449767O14920Espacenet
EP 4650780 A22025-11-1915338O14920Espacenet
JP 2025524002 A2025-07-2528O14920Espacenet
JP 2025517970 A2025-06-1215338O14920Espacenet
KR 1020250067969 A2025-05-1542O14920Espacenet
EP 4541373 A12025-04-235O14920Espacenet
KR 1020250039465 A2025-03-2028O14920Espacenet
WO 2025058068 A2025-03-201O14920Espacenet
JP 2024178415 A2024-12-24412O14920Espacenet

Drugs 7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AS-602868CHEMBL129857Inhibitor of nuclear factor kappa B kinase beta subunit inhibitorINHIBITORChEMBL
BARDOXOLONE METHYLCHEMBL1762621Inhibitor of nuclear factor kappa B kinase beta subunit inhibitorINHIBITORChEMBL
IMD-0354CHEMBL536151Inhibitor of nuclear factor kappa B kinase beta subunit inhibitorINHIBITORChEMBL
IMD-1041CHEMBL3545168Inhibitor of nuclear factor kappa B kinase beta subunit inhibitorINHIBITORChEMBL
IMD-2560CHEMBL3545147Inhibitor of nuclear factor kappa B kinase beta subunit inhibitorINHIBITORChEMBL
MLN-0415CHEMBL5314383Inhibitor of nuclear factor kappa B kinase beta subunit inhibitorINHIBITORChEMBL
SAR-113945CHEMBL3544945Inhibitor of nuclear factor kappa B kinase beta subunit inhibitorINHIBITORChEMBL

Trials 28

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04702997BARDOXOLONE METHYLPHASE22022-12-01ClinicalTrials.gov
NCT04494646BARDOXOLONE METHYLPHASE22022-01-12ClinicalTrials.gov
NCT04018339BARDOXOLONE METHYLPHASE1ClinicalTrials.gov
NCT03918447BARDOXOLONE METHYLPHASE32024-06-11ClinicalTrials.gov
NCT03749447BARDOXOLONE METHYLPHASE32024-03-19ClinicalTrials.gov
NCT03550443BARDOXOLONE METHYLPHASE3ClinicalTrials.gov
NCT03366337BARDOXOLONE METHYLPHASE22022-01-18ClinicalTrials.gov
NCT03068130BARDOXOLONE METHYLPHASE32023-10-12ClinicalTrials.gov
NCT03019185BARDOXOLONE METHYLPHASE2/PHASE32023-10-11ClinicalTrials.gov
NCT02657356BARDOXOLONE METHYLPHASE32023-05-19ClinicalTrials.gov

NIH grants 6944

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant792,025NIH's project files
P30CA068485Cancer Center Support Grant222,025NIH's project files
P01CA125066Discovery of Anticancer Agents of Diverse Natural Origin172,025NIH's project files
P30CA008748Cancer Center Support Grant142,025NIH's project files
P30CA016058Cancer Center Support Grant142,025NIH's project files
R01CA097098Targeting the MUC1-C Oncoprotein in Triple-Negative Breast Cancer142,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase132,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center132,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases132,025NIH's project files
ZIABC011008Oncogenic mechanisms and molecular targets in lymphoma132,025NIH's project files

Papers 13054

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42817588PubTator, text miningPubMed
42815874PubTator, text miningPubMed
42807127PubTator, text miningPubMed
42794861PubTator, text miningPubMed
42794587PubTator, text miningPubMed
42793128PubTator, text miningPubMed
42787468PubTator, text miningPubMed
42785104PubTator, text miningPubMed
42769100PubTator, text miningPubMed
42766431PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license