ConductScience.org, home

Library / Genes

IL1A: interleukin 1 alpha

1 protein, 208 patents, 2 drugs, 28 trials, 25,223 NIH grants and 85,155 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIL1AHGNC
Nameinterleukin 1 alphaHGNC
NCBI Gene ID3552NCBI Gene
HGNC IDHGNC:5991HGNC
EnsemblENSG00000115008NCBI Gene
AliasesIL-1 alpha, IL-1A, IL1, IL1-ALPHA, IL1F1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P01583Interleukin-1 alpha2714Ensembl, GeneID, HGNCUniProt

Patents 208

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4757832 A12026-06-171P01583Espacenet
JP 2026086743 A2026-05-26111P01583Espacenet
JP 2026082951 A2026-05-1911P01583Espacenet
EP 4705273 A22026-03-11269P01583Espacenet
JP 2026506704 A2026-02-251P01583Espacenet
JP 2026502588 A2026-01-23112P01583Espacenet
US 12528850 B22026-01-204P01583Espacenet
EP 4649158 A12025-11-19112P01583Espacenet
US 12473363 B22025-11-18891P01583Espacenet
EP 4641201 A22025-10-291765P01583Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BERMEKIMABCHEMBL2109653Interleukin-1 alpha inhibitorINHIBITORChEMBL
LUTIKIZUMABCHEMBL4594518Interleukin-1 alpha inhibitorINHIBITORChEMBL

Trials 28

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06972446LUTIKIZUMABPHASE2ClinicalTrials.gov
NCT06865105LUTIKIZUMABPHASE2ClinicalTrials.gov
NCT06718101LUTIKIZUMABPHASE2ClinicalTrials.gov
NCT06548542LUTIKIZUMABPHASE2ClinicalTrials.gov
NCT06524635LUTIKIZUMABPHASE2ClinicalTrials.gov
NCT06468228LUTIKIZUMABPHASE3ClinicalTrials.gov
NCT06257875LUTIKIZUMABPHASE2ClinicalTrials.gov
NCT05139602LUTIKIZUMABPHASE2ClinicalTrials.gov
NCT04990440BERMEKIMABPHASE22023-05-24ClinicalTrials.gov
NCT04988308BERMEKIMABPHASE22023-11-13ClinicalTrials.gov

NIH grants 25223

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01AI015614Pathogenesis of Fever in Man2742,025NIH's project files
P30CA016672Cancer Center Support Grant1492,025NIH's project files
P30CA008748Cancer Center Support Grant1152,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award692,025NIH's project files
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition572,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant432,025NIH's project files
P30CA047904Cancer Center Support Grant392,025NIH's project files
P30CA016058Cancer Center Support Grant382,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant342,025NIH's project files
ZIDAR041180Clinical Support Services for the NIAMS Intramural Research Program312,025NIH's project files

Papers 85155

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826468PubTator, text miningPubMed
42825912PubTator, text miningPubMed
42824810PubTator, text miningPubMed
42821193PubTator, text miningPubMed
42819443PubTator, text miningPubMed
42816246PubTator, text miningPubMed
42814173PubTator, text miningPubMed
42811661PubTator, text miningPubMed
42804572PubTator, text miningPubMed
42800590PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license