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IL1B: interleukin 1 beta

1 protein, 349 patents, 5 drugs, 139 trials, 44,185 NIH grants and 207,658 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIL1BHGNC
Nameinterleukin 1 betaHGNC
NCBI Gene ID3553NCBI Gene
HGNC IDHGNC:5992HGNC
EnsemblENSG00000125538NCBI Gene
AliasesIL-1, IL-1B, IL1-BETA, IL1F2, IL1betaNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P01584Interleukin-1 beta26964Ensembl, GeneID, HGNCUniProt

Patents 349

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4757832 A12026-06-172P01584Espacenet
JP 2026517179 A2026-05-288P01584Espacenet
JP 2026086743 A2026-05-26113P01584Espacenet
JP 2026082951 A2026-05-1912P01584Espacenet
EP 4727569 A12026-04-221P01584Espacenet
EP 4713461 A22026-03-258P01584Espacenet
EP 4705273 A22026-03-11267P01584Espacenet
EP 4705273 A22026-03-11274P01584Espacenet
EP 4705483 A12026-03-1116P01584Espacenet
JP 2026506704 A2026-02-252P01584Espacenet

Drugs 5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CANAKINUMABCHEMBL1201834Interleukin-1 beta inhibitorINHIBITORChEMBL
CDP-484CHEMBL2109459Interleukin-1 beta inhibitorINHIBITORChEMBL
GEVOKIZUMABCHEMBL1743026Interleukin-1 beta negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL
LUTIKIZUMABCHEMBL4594518Interleukin-1 beta inhibitorINHIBITORChEMBL
RILONACEPTCHEMBL1201830Interleukin-1 beta inhibitorINHIBITORChEMBL

Trials 139

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06972446LUTIKIZUMABPHASE2ClinicalTrials.gov
NCT06865105LUTIKIZUMABPHASE2ClinicalTrials.gov
NCT06838143CANAKINUMABClinicalTrials.gov
NCT06718101LUTIKIZUMABPHASE2ClinicalTrials.gov
NCT06691217CANAKINUMABPHASE2ClinicalTrials.gov
NCT06660732RILONACEPTPHASE2ClinicalTrials.gov
NCT06548542LUTIKIZUMABPHASE2ClinicalTrials.gov
NCT06524635LUTIKIZUMABPHASE2ClinicalTrials.gov
NCT06497491CANAKINUMABPHASE3ClinicalTrials.gov
NCT06468228LUTIKIZUMABPHASE3ClinicalTrials.gov

NIH grants 44185

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant2482,025NIH's project files
R01AI015614Pathogenesis of Fever in Man2432,025NIH's project files
P30CA008748Cancer Center Support Grant2082,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award2032,025NIH's project files
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition1282,025NIH's project files
P30CA016058Cancer Center Support Grant1002,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases962,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)942,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant882,025NIH's project files
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital872,025NIH's project files

Papers 207658

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827322PubTator, text miningPubMed
42826830PubTator, text miningPubMed
42826468PubTator, text miningPubMed
42825992PubTator, text miningPubMed
42825916PubTator, text miningPubMed
42825488PubTator, text miningPubMed
42824408PubTator, text miningPubMed
42824291PubTator, text miningPubMed
42823874PubTator, text miningPubMed
42823398PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license