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IL1R1: interleukin 1 receptor type 1

1 protein, 229 patents, 3 drugs, 133 trials, 7,485 NIH grants and 11,781 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIL1R1HGNC
Nameinterleukin 1 receptor type 1HGNC
NCBI Gene ID3554NCBI Gene
HGNC IDHGNC:5993HGNC
EnsemblENSG00000115594NCBI Gene
AliasesCD121A, CRMO3, D2S1473, IL-1R-alpha, IL-1RT1, IL1R, IL1RA, P80NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P14778Interleukin-1 receptor type 15695Ensembl, GeneID, HGNCUniProt

Patents 229

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12655224 B22026-06-1611P14778Espacenet
EP 4727569 A12026-04-224P14778Espacenet
US 12528850 B22026-01-208P14778Espacenet
JP 2025172069 A2025-11-20214P14778Espacenet
EP 4650780 A22025-11-1912029P14778Espacenet
EP 4641201 A22025-10-2912928P14778Espacenet
EP 4641202 A22025-10-29693P14778Espacenet
EP 4641203 A22025-10-29407P14778Espacenet
JP 2025160224 A2025-10-228P14778Espacenet
JP 2025147176 A2025-10-066962P14778Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMG-108CHEMBL2109458Interleukin-1 receptor antagonistANTAGONISTChEMBL
ANAKINRACHEMBL1201570Interleukin-1 receptor antagonistANTAGONISTChEMBL
MEDI-8968CHEMBL2109607Interleukin-1 receptor inhibitorINHIBITORChEMBL

Trials 133

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07600190ANAKINRAPHASE1ClinicalTrials.gov
NCT07371689ANAKINRAPHASE3ClinicalTrials.gov
NCT07281027ANAKINRAPHASE3ClinicalTrials.gov
NCT07254000ANAKINRAPHASE2ClinicalTrials.gov
NCT07191444ANAKINRAClinicalTrials.gov
NCT06710197ANAKINRAPHASE2ClinicalTrials.gov
NCT06381661ANAKINRAPHASE2ClinicalTrials.gov
NCT06336733ANAKINRAPHASE3ClinicalTrials.gov
NCT06062966ANAKINRAPHASE1ClinicalTrials.gov
NCT05914454ANAKINRAPHASE2ClinicalTrials.gov

NIH grants 7485

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant312,025NIH's project files
P30CA008748Cancer Center Support Grant272,025NIH's project files
R01AI015614Pathogenesis of Fever in Man242,025NIH's project files
P30CA016058Cancer Center Support Grant162,025NIH's project files
ZIDAR041180Clinical Support Services for the NIAMS Intramural Research Program162,025NIH's project files
P30CA047904Cancer Center Support Grant152,025NIH's project files
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation142,025NIH's project files
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital132,025NIH's project files
R01AI124346Innate immune signaling and stress response132,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award132,025NIH's project files

Papers 11781

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821471PubTator, text miningPubMed
42796463PubTator, text miningPubMed
42793211PubTator, text miningPubMed
42791244PubTator, text miningPubMed
42787021PubTator, text miningPubMed
42784256PubTator, text miningPubMed
42781881PubTator, text miningPubMed
42759216PubTator, text miningPubMed
42758243PubTator, text miningPubMed
42755754PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license