Gene · 3556
IL1RAP: interleukin 1 receptor accessory protein
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IL1RAP: interleukin 1 receptor accessory protein. Genes, record 3556. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3556
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NPH3 | Interleukin-1 receptor accessory protein | 570 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents177
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4757832 A1 | 2026-06-17 | 5 | Q9NPH3 | Espacenet |
| US 12624114 B2 | 2026-05-12 | 353 | Q9NPH3 | Espacenet |
| US 12612462 B2 | 2026-04-28 | 353 | Q9NPH3 | Espacenet |
| JP 2026016421 A | 2026-02-03 | 353 | Q9NPH3 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 50121 | Q9NPH3 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 50123 | Q9NPH3 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 50127 | Q9NPH3 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 50129 | Q9NPH3 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 96 | Q9NPH3 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6972 | Q9NPH3 | Espacenet |
1 to 10 of 177
See all 177 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials39
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06886009 | SPESOLIMAB | ClinicalTrials.gov | ||
| NCT06624670 | SPESOLIMAB | PHASE3 | ClinicalTrials.gov | |
| NCT06241573 | SPESOLIMAB | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT06092216 | SPESOLIMAB | PHASE2 | ClinicalTrials.gov | |
| NCT05878769 | ASTEGOLIMAB | PHASE3 | ClinicalTrials.gov | |
| NCT05856526 | SPESOLIMAB | PHASE2/PHASE3 | 2026-03-12 | ClinicalTrials.gov |
| NCT05819398 | SPESOLIMAB | PHASE2/PHASE3 | 2025-11-05 | ClinicalTrials.gov |
| NCT05670821 | SPESOLIMAB | ClinicalTrials.gov | ||
| NCT05595642 | ASTEGOLIMAB | PHASE3 | ClinicalTrials.gov | |
| NCT05366855 | IMSIDOLIMAB | PHASE3 | ClinicalTrials.gov |
1 to 10 of 39
See all 39 trialsNIH grants1,589
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IL1RAP papers | Newest fiscal year |
|---|---|---|---|
| R01AI015614 | Pathogenesis of Fever in Man | 14 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 10 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| R01HL076246 | Chemokines in healing myocardial infarction | 4 | 2025 |
| R01HL085440 | Resolution of inflammation in healing myocardial infarcts | 4 | 2025 |
| P20GM121176 | Autophagy, Inflammation and Metabolism (AIM) in Disease Center - Phase 2. | 3 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 3 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 3 | 2025 |
| U24AG021886 | National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) | 3 | 2025 |
| P20GM148302 | COBRE in Neurodevelopment and Its Disorders | 2 | 2025 |
1 to 10 of 1,589Source NIH's project files
See all 1,589 nih grantsPapers2,323
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The cytokine structural homologs IL-1β and IL-1Ra have distinct dynamical character that potentially influence their roles in allosteric regulation of the IL-1 receptor. | bioRxiv | 2026 | 42787021 | PubTator, text mining | PubMed |
| Treatment-Driven Peripheral Blood Transcriptomic Remodeling and Baseline Predictors of ESSDAI and STAR Response to B Cell Therapy in Sjögren's Disease. | Arthritis Rheumatol | 2026 | 42781881 | PubTator, text mining | PubMed |
| Integrated transcriptomic and immune-associated network analysis of breast cancer patient-derived organoids reveals candidate inflammatory biomarkers. | Front Bioeng Biotechnol | 2026 | 42729469 | PubTator, text mining | PubMed |
| Coordinated inflammatory macrophage and vascular smooth muscle cell remodeling signatures in human atherosclerosis: An integrative single-cell and bulk transcriptomic analysis. | J Cell Commun Signal | 2026 | 42695089 | PubTator, text mining | PubMed |
| IL1RAP Is Associated With an Inflammation-Immunity-Related State in Skin Cutaneous Melanoma: Integrative Evidence From Pan-Cancer Data and Melanoma Immunotherapy Cohorts. | Int J Genomics | 2026 | 42683052 | PubTator, text mining | PubMed |
| Interleukin-1 Receptor Accessory Protein Amplifies Trophoblast Inflammatory Signaling in Inflammation-Associated Preterm Birth. | Am J Reprod Immunol | 2026 | 42606825 | PubTator, text mining | PubMed |
| Structural and functional consequences of IL33 and IL1RL1 coding variants on IL-33/ST2 signaling. | Genes Immun | 2026 | 42552443 | PubTator, text mining | PubMed |
| Gene-Based Clustering Identifies QSOX1 and IL1RAP as Biomarkers of Metabolic Dysfunction-Associated Steatotic Liver Disease. | Liver Int | 2026 | 42522643 | PubTator, text mining | PubMed |
| Genomic Evidence Links Inflammation to Residual Pulmonary Vascular Obstruction and Risk of Pulmonary Embolism Recurrence. | medRxiv | 2026 | 42465927 | PubTator, text mining | PubMed |
| IL1RAP-expressing myeloid-stromal networks represent a therapeutic vulnerability to improve chemoimmunotherapy sensitivity in pancreatic cancer. | JCI Insight | 2026 | 42325091 | PubTator, text mining | PubMed |
1 to 10 of 2,323
See all 2,323 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3556
GET https://conductscience.org/api/genes/v1/3556/patents?page=2