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Gene · 3556

IL1RAP: interleukin 1 receptor accessory protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IL1RAP: interleukin 1 receptor accessory protein. Genes, record 3556. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3556

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Gene

Symbol
IL1RAP
HGNC
Name
interleukin 1 receptor accessory protein
HGNC
NCBI Gene ID
3556
NCBI Gene
HGNC ID
HGNC:5995
HGNC
Ensembl
ENSG00000196083
NCBI Gene
Aliases
C3orf13, IL-1RAcP, IL1R3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NPH3Interleukin-1 receptor accessory protein5703Ensembl, GeneID, HGNC

Source UniProt

Patents177

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4757832 A12026-06-175Q9NPH3Espacenet
US 12624114 B22026-05-12353Q9NPH3Espacenet
US 12612462 B22026-04-28353Q9NPH3Espacenet
JP 2026016421 A2026-02-03353Q9NPH3Espacenet
JP 2026004568 A2026-01-1450121Q9NPH3Espacenet
JP 2026004568 A2026-01-1450123Q9NPH3Espacenet
JP 2026004568 A2026-01-1450127Q9NPH3Espacenet
JP 2026004568 A2026-01-1450129Q9NPH3Espacenet
EP 4650780 A22025-11-1996Q9NPH3Espacenet
JP 2025147176 A2025-10-066972Q9NPH3Espacenet

1 to 10 of 177

See all 177 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ASTEGOLIMABCHEMBL4594385IL-33 receptor (ST2) inhibitorINHIBITORChEMBL
IMSIDOLIMABCHEMBL4650441IL36 receptor antagonistANTAGONISTChEMBL
SPESOLIMABCHEMBL4297911IL36 receptor antagonistANTAGONISTChEMBL

Trials39

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06886009SPESOLIMABClinicalTrials.gov
NCT06624670SPESOLIMABPHASE3ClinicalTrials.gov
NCT06241573SPESOLIMABPHASE2/PHASE3ClinicalTrials.gov
NCT06092216SPESOLIMABPHASE2ClinicalTrials.gov
NCT05878769ASTEGOLIMABPHASE3ClinicalTrials.gov
NCT05856526SPESOLIMABPHASE2/PHASE32026-03-12ClinicalTrials.gov
NCT05819398SPESOLIMABPHASE2/PHASE32025-11-05ClinicalTrials.gov
NCT05670821SPESOLIMABClinicalTrials.gov
NCT05595642ASTEGOLIMABPHASE3ClinicalTrials.gov
NCT05366855IMSIDOLIMABPHASE3ClinicalTrials.gov

1 to 10 of 39

See all 39 trials

NIH grants1,589

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIL1RAP papersNewest fiscal year
R01AI015614Pathogenesis of Fever in Man142025
P30CA016672Cancer Center Support Grant102025
P30CA008748Cancer Center Support Grant62025
R01HL076246Chemokines in healing myocardial infarction42025
R01HL085440Resolution of inflammation in healing myocardial infarcts42025
P20GM121176Autophagy, Inflammation and Metabolism (AIM) in Disease Center - Phase 2.32025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center32025
P30CA086862Cancer Center Support Grant32025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)32025
P20GM148302COBRE in Neurodevelopment and Its Disorders22025

1 to 10 of 1,589Source NIH's project files

See all 1,589 nih grants

Papers2,323

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The cytokine structural homologs IL-1β and IL-1Ra have distinct dynamical character that potentially influence their roles in allosteric regulation of the IL-1 receptor.bioRxiv202642787021PubTator, text miningPubMed
Treatment-Driven Peripheral Blood Transcriptomic Remodeling and Baseline Predictors of ESSDAI and STAR Response to B Cell Therapy in Sjögren's Disease.Arthritis Rheumatol202642781881PubTator, text miningPubMed
Integrated transcriptomic and immune-associated network analysis of breast cancer patient-derived organoids reveals candidate inflammatory biomarkers.Front Bioeng Biotechnol202642729469PubTator, text miningPubMed
Coordinated inflammatory macrophage and vascular smooth muscle cell remodeling signatures in human atherosclerosis: An integrative single-cell and bulk transcriptomic analysis.J Cell Commun Signal202642695089PubTator, text miningPubMed
IL1RAP Is Associated With an Inflammation-Immunity-Related State in Skin Cutaneous Melanoma: Integrative Evidence From Pan-Cancer Data and Melanoma Immunotherapy Cohorts.Int J Genomics202642683052PubTator, text miningPubMed
Interleukin-1 Receptor Accessory Protein Amplifies Trophoblast Inflammatory Signaling in Inflammation-Associated Preterm Birth.Am J Reprod Immunol202642606825PubTator, text miningPubMed
Structural and functional consequences of IL33 and IL1RL1 coding variants on IL-33/ST2 signaling.Genes Immun202642552443PubTator, text miningPubMed
Gene-Based Clustering Identifies QSOX1 and IL1RAP as Biomarkers of Metabolic Dysfunction-Associated Steatotic Liver Disease.Liver Int202642522643PubTator, text miningPubMed
Genomic Evidence Links Inflammation to Residual Pulmonary Vascular Obstruction and Risk of Pulmonary Embolism Recurrence.medRxiv202642465927PubTator, text miningPubMed
IL1RAP-expressing myeloid-stromal networks represent a therapeutic vulnerability to improve chemoimmunotherapy sensitivity in pancreatic cancer.JCI Insight202642325091PubTator, text miningPubMed

1 to 10 of 2,323

See all 2,323 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3556

GET https://conductscience.org/api/genes/v1/3556/patents?page=2