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IL1RN: interleukin 1 receptor antagonist

1 protein, 301 patents, 0 drugs, 0 trials, 9,627 NIH grants and 22,780 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIL1RNHGNC
Nameinterleukin 1 receptor antagonistHGNC
NCBI Gene ID3557NCBI Gene
HGNC IDHGNC:6000HGNC
EnsemblENSG00000136689NCBI Gene
AliasesCRMO2, DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MGC10430, MVCD4NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P18510Interleukin-1 receptor antagonist protein1775Ensembl, GeneID, HGNCUniProt

Patents 301

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4791763 A12026-08-193P18510Espacenet
EP 4757832 A12026-06-17399P18510Espacenet
JP 2026090244 A2026-06-02410P18510Espacenet
JP 2026090244 A2026-06-02450P18510Espacenet
JP 2026086743 A2026-05-26115P18510Espacenet
JP 2026515795 A2026-05-1950P18510Espacenet
EP 4720303 A22026-04-081P18510Espacenet
JP 2026506963 A2026-02-276P18510Espacenet
EP 4698654 A12026-02-2537P18510Espacenet
EP 4695404 A12026-02-1850P18510Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 9627

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01AI015614Pathogenesis of Fever in Man1122,025NIH's project files
P30CA016672Cancer Center Support Grant422,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award302,025NIH's project files
P30CA008748Cancer Center Support Grant292,025NIH's project files
P51OD011104Tulane National Primate Research Center272,025NIH's project files
P51OD011092Support for National Primate Research Center222,025NIH's project files
P30ES010126UNC Center for Environmental Health and Susceptibility182,025NIH's project files
P30CA015704Cancer Center Support Grant172,025NIH's project files
ZIAAG001050The InChianti Study172,025NIH's project files
ZIDAR041180Clinical Support Services for the NIAMS Intramural Research Program172,025NIH's project files

Papers 22780

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821193PubTator, text miningPubMed
42812632PubTator, text miningPubMed
42811433PubTator, text miningPubMed
42808173PubTator, text miningPubMed
42807254PubTator, text miningPubMed
42806711PubTator, text miningPubMed
42791567PubTator, text miningPubMed
42787021PubTator, text miningPubMed
42785962PubTator, text miningPubMed
42784239PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license