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IL2RA: interleukin 2 receptor subunit alpha

1 protein, 418 patents, 8 drugs, 819 trials, 17,840 NIH grants and 51,814 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIL2RAHGNC
Nameinterleukin 2 receptor subunit alphaHGNC
NCBI Gene ID3559NCBI Gene
HGNC IDHGNC:6008HGNC
EnsemblENSG00000134460NCBI Gene
AliasesCD25, IDDM10, IL2R, IMD41, TCGFR, p55NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P01589Interleukin-2 receptor subunit alpha27210Ensembl, GeneID, HGNCUniProt

Patents 418

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4824105 A12026-10-21426P01589Espacenet
EP 4795154 A12026-08-26128P01589Espacenet
EP 4780842 A12026-07-2929P01589Espacenet
EP 4780863 A12026-07-2929P01589Espacenet
EP 4750799 A12026-06-032P01589Espacenet
US 12617829 B22026-05-0563P01589Espacenet
JP 2026513839 A2026-05-01855P01589Espacenet
JP 2026508209 A2026-03-1064P01589Espacenet
EP 4692351 A12026-02-1117P01589Espacenet
US 12534505 B22026-01-2763P01589Espacenet

Drugs 8

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALDESLEUKINCHEMBL1201438Interleukin-2 receptor agonistAGONISTChEMBL
ANTI-TAC 90 Y-HATCHEMBL2109366Interleukin-2 receptor alpha chain binding agentBINDING AGENTChEMBL
BASILIXIMABCHEMBL1201439Interleukin-2 receptor inhibitorINHIBITORChEMBL
CAMIDANLUMAB TESIRINECHEMBL4297871Interleukin-2 receptor alpha chain binding agentBINDING AGENTChEMBL
DACLIZUMABCHEMBL1201605Interleukin-2 receptor inhibitorINHIBITORChEMBL
DENILEUKIN DIFTITOXCHEMBL1201550Interleukin-2 receptor binding agentBINDING AGENTChEMBL
INOLIMOMABCHEMBL2108370Interleukin-2 receptor alpha chain antagonistANTAGONISTChEMBL
LMB-2CHEMBL2109367Interleukin-2 receptor alpha chain binding agentBINDING AGENTChEMBL

Trials 819

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07591649ALDESLEUKINPHASE1/PHASE2ClinicalTrials.gov
NCT07589842ALDESLEUKINPHASE2ClinicalTrials.gov
NCT07443020ALDESLEUKINPHASE1ClinicalTrials.gov
NCT07389239ALDESLEUKINPHASE1/PHASE2ClinicalTrials.gov
NCT07288073ALDESLEUKINPHASE2ClinicalTrials.gov
NCT07269158ALDESLEUKINPHASE1/PHASE2ClinicalTrials.gov
NCT07225439ALDESLEUKINPHASE1ClinicalTrials.gov
NCT07192900ALDESLEUKINPHASE1ClinicalTrials.gov
NCT07161999ALDESLEUKINPHASE2/PHASE3ClinicalTrials.gov
NCT07105176ALDESLEUKINPHASE1ClinicalTrials.gov

NIH grants 17840

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1912,025NIH's project files
P30CA016672Cancer Center Support Grant1692,025NIH's project files
P30AI027763UCSF-Bay Area Center for AIDS Research862,025NIH's project files
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies832,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award752,025NIH's project files
P01AI039671Costimulatory Mechanisms of Autoimmunity622,025NIH's project files
P30CA016042Cancer Center Support Grant592,025NIH's project files
P30CA016058Cancer Center Support Grant542,025NIH's project files
P30CA047904Cancer Center Support Grant542,025NIH's project files
P30CA016520Abramson Cancer Center Support Grant522,025NIH's project files

Papers 51814

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42817849PubTator, text miningPubMed
42815193PubTator, text miningPubMed
42814321PubTator, text miningPubMed
42812538PubTator, text miningPubMed
42812170PubTator, text miningPubMed
42809620PubTator, text miningPubMed
42808777PubTator, text miningPubMed
42806637PubTator, text miningPubMed
42802461PubTator, text miningPubMed
42801723PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license