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IL2RB: interleukin 2 receptor subunit beta

1 protein, 305 patents, 10 drugs, 858 trials, 7,378 NIH grants and 14,488 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIL2RBHGNC
Nameinterleukin 2 receptor subunit betaHGNC
NCBI Gene ID3560NCBI Gene
HGNC IDHGNC:6009HGNC
EnsemblENSG00000100385NCBI Gene
AliasesCD122, IL15RB, IMD63, P70-75NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P14784Interleukin-2 receptor subunit beta5518Ensembl, GeneID, HGNCUniProt

Patents 305

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4795154 A12026-08-26129P14784Espacenet
EP 4780842 A12026-07-2930P14784Espacenet
EP 4780863 A12026-07-2930P14784Espacenet
EP 4774398 A12026-07-1569P14784Espacenet
EP 4754140 A12026-06-1090P14784Espacenet
EP 4750799 A12026-06-034P14784Espacenet
JP 2026076241 A2026-05-1110P14784Espacenet
JP 2026076241 A2026-05-111119P14784Espacenet
US 12617829 B22026-05-0564P14784Espacenet
JP 2026513839 A2026-05-01500P14784Espacenet

Drugs 10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALDESLEUKINCHEMBL1201438Interleukin-2 receptor agonistAGONISTChEMBL
BASILIXIMABCHEMBL1201439Interleukin-2 receptor inhibitorINHIBITORChEMBL
DACLIZUMABCHEMBL1201605Interleukin-2 receptor inhibitorINHIBITORChEMBL
DENILEUKIN DIFTITOXCHEMBL1201550Interleukin-2 receptor binding agentBINDING AGENTChEMBL
HUMIK-BETA-1CHEMBL2109610Interleukin-2 receptor beta chain inhibitorINHIBITORChEMBL
MIK-BETA-1CHEMBL2109326Interleukin-2 receptor beta chain inhibitorINHIBITORChEMBL
NOGAPENDEKIN ALFA INBAKICEPTCHEMBL6068330Interleukin-15 receptor agonistAGONISTChEMBL
PEGENZILEUKINCHEMBL4650426IL-2R beta/gamma agonistAGONISTChEMBL
RECOMBINANT HUMAN INTERLEUKIN-15CHEMBL4650421Interleukin-15 receptor agonistAGONISTChEMBL
SIMLUKAFUSP ALFACHEMBL4298090IL-2R beta/gamma binding agentBINDING AGENTChEMBL

Trials 858

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07591649ALDESLEUKINPHASE1/PHASE2ClinicalTrials.gov
NCT07589842ALDESLEUKINPHASE2ClinicalTrials.gov
NCT07578558NOGAPENDEKIN ALFA INBAKICEPTPHASE2ClinicalTrials.gov
NCT07524257NOGAPENDEKIN ALFA INBAKICEPTPHASE3ClinicalTrials.gov
NCT07492888NOGAPENDEKIN ALFA INBAKICEPTPHASE2ClinicalTrials.gov
NCT07492875NOGAPENDEKIN ALFA INBAKICEPTPHASE3ClinicalTrials.gov
NCT07488884NOGAPENDEKIN ALFA INBAKICEPTPHASE1ClinicalTrials.gov
NCT07443020ALDESLEUKINPHASE1ClinicalTrials.gov
NCT07389239ALDESLEUKINPHASE1/PHASE2ClinicalTrials.gov
NCT07355205NOGAPENDEKIN ALFA INBAKICEPTPHASE1/PHASE2ClinicalTrials.gov

NIH grants 7378

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant612,025NIH's project files
P30CA016672Cancer Center Support Grant442,025NIH's project files
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies312,025NIH's project files
P30CA016058Cancer Center Support Grant262,025NIH's project files
R01AI051321Structure-based engineering of immune cytokine signaling222,025NIH's project files
P01CA111412NK cells, their receptors and cancer therapy202,025NIH's project files
ZIAHL005401IL-2 Family Cytokines and their Receptors-- Biology of the IL-2 system192,025NIH's project files
P30CA086862Cancer Center Support Grant182,025NIH's project files
ZIAHL005402IL-2 Family Cytokines and Receptors-- Mechanisms of Regulation & Action182,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)172,025NIH's project files

Papers 14488

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42801536PubTator, text miningPubMed
42793007PubTator, text miningPubMed
42778612PubTator, text miningPubMed
42771543PubTator, text miningPubMed
42763309PubTator, text miningPubMed
42742904PubTator, text miningPubMed
42732228PubTator, text miningPubMed
42731883PubTator, text miningPubMed
42708038PubTator, text miningPubMed
42706545PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license