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IL2RG: interleukin 2 receptor subunit gamma

1 protein, 326 patents, 8 drugs, 854 trials, 4,787 NIH grants and 6,229 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIL2RGHGNC
Nameinterleukin 2 receptor subunit gammaHGNC
NCBI Gene ID3561NCBI Gene
HGNC IDHGNC:6010HGNC
EnsemblENSG00000147168NCBI Gene
AliasesCD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P31785Cytokine receptor common subunit gamma36914Ensembl, GeneID, HGNCUniProt

Patents 326

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4780842 A12026-07-2931P31785Espacenet
EP 4780863 A12026-07-2931P31785Espacenet
EP 4750799 A12026-06-036P31785Espacenet
JP 2026076241 A2026-05-1112P31785Espacenet
JP 2026076241 A2026-05-111121P31785Espacenet
US 12617829 B22026-05-0565P31785Espacenet
JP 2026012683 A2026-01-2723P31785Espacenet
US 12534505 B22026-01-2765P31785Espacenet
EP 4680645 A12026-01-214P31785Espacenet
US 12528850 B22026-01-2048P31785Espacenet

Drugs 8

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALDESLEUKINCHEMBL1201438Interleukin-2 receptor agonistAGONISTChEMBL
BASILIXIMABCHEMBL1201439Interleukin-2 receptor inhibitorINHIBITORChEMBL
DACLIZUMABCHEMBL1201605Interleukin-2 receptor inhibitorINHIBITORChEMBL
DENILEUKIN DIFTITOXCHEMBL1201550Interleukin-2 receptor binding agentBINDING AGENTChEMBL
NOGAPENDEKIN ALFA INBAKICEPTCHEMBL6068330Interleukin-15 receptor agonistAGONISTChEMBL
PEGENZILEUKINCHEMBL4650426IL-2R beta/gamma agonistAGONISTChEMBL
RECOMBINANT HUMAN INTERLEUKIN-15CHEMBL4650421Interleukin-15 receptor agonistAGONISTChEMBL
SIMLUKAFUSP ALFACHEMBL4298090IL-2R beta/gamma binding agentBINDING AGENTChEMBL

Trials 854

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07591649ALDESLEUKINPHASE1/PHASE2ClinicalTrials.gov
NCT07589842ALDESLEUKINPHASE2ClinicalTrials.gov
NCT07578558NOGAPENDEKIN ALFA INBAKICEPTPHASE2ClinicalTrials.gov
NCT07524257NOGAPENDEKIN ALFA INBAKICEPTPHASE3ClinicalTrials.gov
NCT07492888NOGAPENDEKIN ALFA INBAKICEPTPHASE2ClinicalTrials.gov
NCT07492875NOGAPENDEKIN ALFA INBAKICEPTPHASE3ClinicalTrials.gov
NCT07488884NOGAPENDEKIN ALFA INBAKICEPTPHASE1ClinicalTrials.gov
NCT07443020ALDESLEUKINPHASE1ClinicalTrials.gov
NCT07389239ALDESLEUKINPHASE1/PHASE2ClinicalTrials.gov
NCT07355205NOGAPENDEKIN ALFA INBAKICEPTPHASE1/PHASE2ClinicalTrials.gov

NIH grants 4787

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant552,025NIH's project files
P30CA016672Cancer Center Support Grant242,025NIH's project files
ZIAHL005401IL-2 Family Cytokines and their Receptors-- Biology of the IL-2 system242,025NIH's project files
ZIAHL005402IL-2 Family Cytokines and Receptors-- Mechanisms of Regulation & Action242,025NIH's project files
R13AI094943Annual Primary Immune Deficiency Treatment Consortium (PIDTC) Workshop and Education Day232,025NIH's project files
ZIAAI001222Characterization of the cellular and molecular bases of inborn errors of immunity222,025NIH's project files
R01AI051321Structure-based engineering of immune cytokine signaling212,025NIH's project files
ZIAAI000644Gene Therapy and Hematopoietic Stem Cell Research to Treat Inherited Primary Immune Deficiencies212,025NIH's project files
P30CA034196Cancer Center Support (CORE) Grant202,025NIH's project files
ZIAAI000645Development and Clinical Application of Gene and Cell therapies for Patients with Immune Deficiencies172,025NIH's project files

Papers 6229

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824078PubTator, text miningPubMed
42820686PubTator, text miningPubMed
42810908PubTator, text miningPubMed
42799887PubTator, text miningPubMed
42771543PubTator, text miningPubMed
42687392PubTator, text miningPubMed
42683527PubTator, text miningPubMed
42657226PubTator, text miningPubMed
42627218PubTator, text miningPubMed
42588651PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license