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IL4R: interleukin 4 receptor

1 protein, 237 patents, 2 drugs, 194 trials, 4,580 NIH grants and 8,195 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIL4RHGNC
Nameinterleukin 4 receptorHGNC
NCBI Gene ID3566NCBI Gene
HGNC IDHGNC:6015HGNC
EnsemblENSG00000077238NCBI Gene
AliasesCD124, IL-4RA, IL4RANCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P24394Interleukin-4 receptor subunit alpha82510Ensembl, GeneID, HGNCUniProt

Patents 237

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4795154 A12026-08-26134P24394Espacenet
EP 4755920 A12026-06-105P24394Espacenet
EP 4705273 A22026-03-11300P24394Espacenet
JP 2026505955 A2026-02-20237P24394Espacenet
JP 2026004568 A2026-01-1450249P24394Espacenet
JP 2026004568 A2026-01-1450252P24394Espacenet
JP 2026004568 A2026-01-1450254P24394Espacenet
WO 2025264972 A12025-12-26301P24394Espacenet
EP 4665757 A22025-12-24237P24394Espacenet
EP 4650780 A22025-11-1911314P24394Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CINTREDEKIN BESUDOTOXCHEMBL2108583Interleukin 13 receptor binding agentBINDING AGENTChEMBL
DUPILUMABCHEMBL2108675Interleukin-4 receptor subunit alpha antagonistANTAGONISTChEMBL

Trials 194

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07574294DUPILUMABClinicalTrials.gov
NCT07467564DUPILUMABClinicalTrials.gov
NCT07448363DUPILUMABClinicalTrials.gov
NCT07399067DUPILUMABPHASE2ClinicalTrials.gov
NCT07386743DUPILUMABPHASE3ClinicalTrials.gov
NCT07358234DUPILUMABEARLY_PHASE1ClinicalTrials.gov
NCT07330934DUPILUMABPHASE2ClinicalTrials.gov
NCT07309614DUPILUMABPHASE3ClinicalTrials.gov
NCT07277322DUPILUMABPHASE1/PHASE2ClinicalTrials.gov
NCT07276425DUPILUMABClinicalTrials.gov

NIH grants 4580

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease232,025NIH's project files
P30CA016672Cancer Center Support Grant212,025NIH's project files
U19AI070235Epithelial Genes in Allergic Inflammation182,025NIH's project files
P30CA008748Cancer Center Support Grant172,025NIH's project files
R01AI065617Genetic and Epigenetic Programming of Allergic Airway Inflammation142,025NIH's project files
T32AI007512Molecular Basis of Allergic and Immunologic Disease132,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant122,025NIH's project files
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success122,025NIH's project files
U19AI095219Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease112,025NIH's project files
UL1TR002345Washington University Institute of Clinical and Translational Sciences112,025NIH's project files

Papers 8195

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42816545PubTator, text miningPubMed
42807314PubTator, text miningPubMed
42806130PubTator, text miningPubMed
42801782PubTator, text miningPubMed
42798376PubTator, text miningPubMed
42797344PubTator, text miningPubMed
42786145PubTator, text miningPubMed
42782552PubTator, text miningPubMed
42781325PubTator, text miningPubMed
42776801PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license