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Gene · 3568

IL5RA: interleukin 5 receptor subunit alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IL5RA: interleukin 5 receptor subunit alpha. Genes, record 3568. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3568

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Gene

Symbol
IL5RA
HGNC
Name
interleukin 5 receptor subunit alpha
HGNC
NCBI Gene ID
3568
NCBI Gene
HGNC ID
HGNC:6017
HGNC
Ensembl
ENSG00000091181
NCBI Gene
Aliases
CD125, CDw125, HSIL5R3, IL5R
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q01344Interleukin-5 receptor subunit alpha4206Ensembl, GeneID, HGNC

Source UniProt

Patents92

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11310Q01344Espacenet
JP 2026004568 A2026-01-1450255Q01344Espacenet
JP 2026004568 A2026-01-1450265Q01344Espacenet
EP 4650780 A22025-11-191582Q01344Espacenet
EP 4641201 A22025-10-291197Q01344Espacenet
EP 4633648 A12025-10-2238Q01344Espacenet
JP 2025147176 A2025-10-067108Q01344Espacenet
JP 2025147176 A2025-10-067112Q01344Espacenet
JP 2025147176 A2025-10-0616759Q01344Espacenet
JP 2025529142 A2025-09-042102Q01344Espacenet

1 to 10 of 92

See all 92 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
BENRALIZUMABCHEMBL1742991Interleukin-5 receptor subunit alpha inhibitorINHIBITOR

Source ChEMBL

Trials69

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07530770BENRALIZUMABClinicalTrials.gov
NCT07444567BENRALIZUMABPHASE3ClinicalTrials.gov
NCT07214753BENRALIZUMABClinicalTrials.gov
NCT06750289BENRALIZUMABPHASE3ClinicalTrials.gov
NCT06512883BENRALIZUMABPHASE3ClinicalTrials.gov
NCT06501807BENRALIZUMABClinicalTrials.gov
NCT06465485BENRALIZUMABPHASE3ClinicalTrials.gov
NCT06456450BENRALIZUMABClinicalTrials.gov
NCT06385236BENRALIZUMABPHASE4ClinicalTrials.gov
NCT06288516BENRALIZUMABPHASE4ClinicalTrials.gov

1 to 10 of 69

See all 69 trials

NIH grants1,077

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIL5RA papersNewest fiscal year
ZIAAI001130Eosinophils and Eosinophil Activation in the Pathogenesis of Human Disease202025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease142025
U19AI070235Epithelial Genes in Allergic Inflammation92025
U19AI095219Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease82025
ZIACL080004Laboratory Assessment of Patients with Hypereosinophilic Syndrome72025
T32AI083216Northwestern University Allergy and Immunology Research (NUAIR) Program62025
R01AI145108The Role of Donor-Derived Eosinophils on Lung Allograft Ischemia Reperfusion Injury52025
U19AI070535Airway Inflammation and Airway Remodeling in Severe Asthma42025
ZIAAI000249The Pathogenesis, Diagnosis, and Treatment of Systemic Mast Cell Disorders42025
R01AI136041Eicosanoid Networks in Aspirin Hypersensitivity32025

1 to 10 of 1,077Source NIH's project files

See all 1,077 nih grants

Papers2,231

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetically inducible coordinators of cytokine signaling pathways for interrogating T cell motility.bioRxiv202642818027PubTator, text miningPubMed
Efficacy and Safety of Biologic Therapies Targeting Type 2 and Epithelial-Alarmin Pathways in Chronic Obstructive Pulmonary Disease: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.
Cureus202642802784PubTator, text miningPubMed
IL-5/IL-5R blockade enables safe non-steroidal anti-inflammatory agent reintroduction in non-steroidal anti-inflammatory exacerbated respiratory disease.Front Immunol202642755689PubTator, text miningPubMed
Benralizumab in Severe Eosinophilic Asthma: Toward Disease Control and Evolving Treatment Paradigms.J Inflamm Res202642741441PubTator, text miningPubMed
Treatment patterns and disease burden of hypereosinophilic syndrome (HES) in the United States: A real-world observational, retrospective cohort study.World Allergy Organ J202642733636PubTator, text miningPubMed
IL-5 biology and eosinophil regulation: Advances, resistance pathways and future directions.Respir Med202642674274PubTator, text miningPubMed
Sequential autoimmune and neoplastic manifestations during long-term benralizumab therapy for severe eosinophilic asthma: A descriptive case report.Respir Med Case Rep202642633250PubTator, text miningPubMed
Integrative Omics of Eosinophils in Asthma and COPD: Deciphering Molecular Signatures for Targeted Therapy.Mol Diagn Ther202642631787PubTator, text miningPubMed
Patient Journey, Treatment Patterns, and Disease Burden of Patients With Idiopathic Hypereosinophilic Syndrome.EJHaem202642614285PubTator, text miningPubMed
Microbiome-driven precision medicine in asthma: Roles of targeted therapies and artificial intelligence.J Asthma202642613688PubTator, text miningPubMed

1 to 10 of 2,231

See all 2,231 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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