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IL6: interleukin 6

1 protein, 570 patents, 9 drugs, 88 trials, 61,294 NIH grants and 371,631 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIL6HGNC
Nameinterleukin 6HGNC
NCBI Gene ID3569NCBI Gene
HGNC IDHGNC:6018HGNC
EnsemblENSG00000136244NCBI Gene
AliasesBSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2, IFNB2, IL-6NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P05231Interleukin-621217Ensembl, GeneID, HGNCUniProt

Patents 570

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4757832 A12026-06-1783P05231Espacenet
JP 2026086743 A2026-05-26137P05231Espacenet
JP 2026062918 A2026-04-1028P05231Espacenet
EP 4705273 A22026-03-11270P05231Espacenet
JP 2026041716 A2026-03-101P05231Espacenet
EP 4694917 A12026-02-18613P05231Espacenet
JP 2026027267 A2026-02-181P05231Espacenet
WO 2026027676 A12026-02-0512P05231Espacenet
WO 2026027676 A12026-02-0514P05231Espacenet
WO 2026022479 A12026-01-295P05231Espacenet

Drugs 9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CLAZAKIZUMABCHEMBL2108589Interleukin-6 inhibitorINHIBITORChEMBL
ELSILIMOMABCHEMBL2108591Interleukin-6 inhibitorINHIBITORChEMBL
MRA 003 USCHEMBL2109615Interleukin-6 inhibitorINHIBITORChEMBL
OLOKIZUMABCHEMBL1743050Interleukin-6 inhibitorINHIBITORChEMBL
PACIBEKITUGCHEMBL6068160Interleukin-6 inhibitorINHIBITORChEMBL
SILTUXIMABCHEMBL1743070Interleukin-6 antagonistANTAGONISTChEMBL
SIRUKUMABCHEMBL1743071Interleukin-6 inhibitorINHIBITORChEMBL
ZILTIVEKIMABCHEMBL4297732Interleukin-6 inhibitorINHIBITORChEMBL
ZILTIVEKIMABCHEMBL4297732Interleukin-6 binding agentBINDING AGENTChEMBL

Trials 88

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07517575OLOKIZUMABPHASE2ClinicalTrials.gov
NCT07301034ZILTIVEKIMABPHASE3ClinicalTrials.gov
NCT07276282ZILTIVEKIMABPHASE3ClinicalTrials.gov
NCT06679829SILTUXIMABPHASE2ClinicalTrials.gov
NCT06447376SILTUXIMABPHASE1ClinicalTrials.gov
NCT06440746OLOKIZUMABPHASE2/PHASE3ClinicalTrials.gov
NCT06362759PACIBEKITUGPHASE2ClinicalTrials.gov
NCT06263244ZILTIVEKIMABPHASE3ClinicalTrials.gov
NCT06200207ZILTIVEKIMABPHASE3ClinicalTrials.gov
NCT05727384CLAZAKIZUMABPHASE2ClinicalTrials.gov

NIH grants 61294

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant6782,025NIH's project files
P30CA008748Cancer Center Support Grant6032,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award3922,025NIH's project files
P30CA016058Cancer Center Support Grant2372,025NIH's project files
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition1862,025NIH's project files
P30CA047904Cancer Center Support Grant1582,025NIH's project files
P30CA006973Regional Oncology Research Center1532,025NIH's project files
P30AG028740University of Florida Older Americans Independence Center (OAIC)1482,025NIH's project files
P30AI027763UCSF-Bay Area Center for AIDS Research1462,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant1442,025NIH's project files

Papers 371631

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827396PubTator, text miningPubMed
42827322PubTator, text miningPubMed
42827282PubTator, text miningPubMed
42827143PubTator, text miningPubMed
42826830PubTator, text miningPubMed
42826430PubTator, text miningPubMed
42826097PubTator, text miningPubMed
42825992PubTator, text miningPubMed
42825942PubTator, text miningPubMed
42825916PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license