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IL6R: interleukin 6 receptor

1 protein, 393 patents, 5 drugs, 438 trials, 7,227 NIH grants and 15,398 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIL6RHGNC
Nameinterleukin 6 receptorHGNC
NCBI Gene ID3570NCBI Gene
HGNC IDHGNC:6019HGNC
EnsemblENSG00000160712NCBI Gene
AliasesCD126, HIES5, IL-1Ra, IL-6R, IL-6R-1, IL-6RA, IL6Q, IL6QTL, IL6RA, IL6RQ, gp80NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P08887Interleukin-6 receptor subunit alpha46810Ensembl, GeneID, HGNCUniProt

Patents 393

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026134203 A2026-06-25106P08887Espacenet
EP 4757832 A12026-06-1784P08887Espacenet
JP 2026094161 A2026-06-0915P08887Espacenet
US 12617847 B22026-05-0515P08887Espacenet
JP 2026068737 A2026-04-22727P08887Espacenet
JP 2026510418 A2026-04-02112P08887Espacenet
EP 4705273 A22026-03-11306P08887Espacenet
JP 2026041716 A2026-03-102P08887Espacenet
JP 2026027267 A2026-02-184P08887Espacenet
JP 2026009878 A2026-01-211P08887Espacenet

Drugs 5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
LEVILIMABCHEMBL4650406Interleukin-6 receptor alpha subunit inhibitorINHIBITORChEMBL
SARILUMABCHEMBL2108730Interleukin-6 receptor alpha subunit antagonistANTAGONISTChEMBL
SATRALIZUMABCHEMBL3833307IL6Ralpha/GP130 antagonistANTAGONISTChEMBL
TOCILIZUMABCHEMBL1237022Interleukin-6 receptor alpha subunit inhibitorINHIBITORChEMBL
VOBARILIZUMABCHEMBL3833343Interleukin-6 receptor alpha subunit inhibitorINHIBITORChEMBL

Trials 438

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07582185TOCILIZUMABPHASE4ClinicalTrials.gov
NCT07509645TOCILIZUMABPHASE3ClinicalTrials.gov
NCT07493317TOCILIZUMABPHASE2ClinicalTrials.gov
NCT07491913TOCILIZUMABClinicalTrials.gov
NCT07484113SARILUMABPHASE1ClinicalTrials.gov
NCT07392814TOCILIZUMABPHASE1ClinicalTrials.gov
NCT07377058TOCILIZUMABClinicalTrials.gov
NCT07281027TOCILIZUMABPHASE3ClinicalTrials.gov
NCT07263776TOCILIZUMABPHASE3ClinicalTrials.gov
NCT07254637TOCILIZUMABPHASE2ClinicalTrials.gov

NIH grants 7227

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant522,025NIH's project files
P30CA016672Cancer Center Support Grant452,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award232,025NIH's project files
P30CA016058Cancer Center Support Grant192,025NIH's project files
P30CA086862Cancer Center Support Grant162,025NIH's project files
P01CA155258Integrative Oncogenomics of Multiple Myeloma142,025NIH's project files
P30CA006973Regional Oncology Research Center142,025NIH's project files
P30CA047904Cancer Center Support Grant142,025NIH's project files
P30CA033572Cancer Center Support Grant132,025NIH's project files
R01AI051321Structure-based engineering of immune cytokine signaling132,025NIH's project files

Papers 15398

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822715PubTator, text miningPubMed
42819758PubTator, text miningPubMed
42818337PubTator, text miningPubMed
42810412PubTator, text miningPubMed
42785662PubTator, text miningPubMed
42782276PubTator, text miningPubMed
42780469PubTator, text miningPubMed
42778654PubTator, text miningPubMed
42777584PubTator, text miningPubMed
42777519PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license