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IL6ST: interleukin 6 cytokine family signal transducer

1 protein, 235 patents, 1 drug, 12 trials, 5,081 NIH grants and 8,953 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIL6STHGNC
Nameinterleukin 6 cytokine family signal transducerHGNC
NCBI Gene ID3572NCBI Gene
HGNC IDHGNC:6021HGNC
EnsemblENSG00000134352NCBI Gene
AliasesCD130, CDW130, GP130, HIES4, HIES4A, HIES4B, IL-6RB, IMD94, STWS2, sGP130NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P40189Interleukin-6 receptor subunit beta91820Ensembl, GeneID, HGNCUniProt

Patents 235

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026063000 A2026-04-101P40189Espacenet
JP 2026510418 A2026-04-02114P40189Espacenet
JP 2026508611 A2026-03-1159P40189Espacenet
JP 2026016604 A2026-02-03701P40189Espacenet
JP 2026502391 A2026-01-224P40189Espacenet
JP 2026004568 A2026-01-1450269P40189Espacenet
JP 2026004568 A2026-01-1450272P40189Espacenet
JP 2026501115 A2026-01-14129P40189Espacenet
WO 2025252885 A12025-12-11129P40189Espacenet
WO 2025250495 A12025-12-0410P40189Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
SATRALIZUMABCHEMBL3833307IL6Ralpha/GP130 antagonistANTAGONISTChEMBL

Trials 12

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06829524SATRALIZUMABClinicalTrials.gov
NCT06450639SATRALIZUMABPHASE2ClinicalTrials.gov
NCT06222827SATRALIZUMABPHASE2ClinicalTrials.gov
NCT06106828SATRALIZUMABPHASE3ClinicalTrials.gov
NCT05987423SATRALIZUMABPHASE3ClinicalTrials.gov
NCT05679570SATRALIZUMABPHASE2ClinicalTrials.gov
NCT05269667SATRALIZUMABPHASE42025-01-22ClinicalTrials.gov
NCT05199688SATRALIZUMABPHASE3ClinicalTrials.gov
NCT04963270SATRALIZUMABPHASE32025-02-28ClinicalTrials.gov
NCT04660539SATRALIZUMABPHASE32024-12-27ClinicalTrials.gov

NIH grants 5081

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant472,025NIH's project files
P30CA008748Cancer Center Support Grant242,025NIH's project files
R01AI051321Structure-based engineering of immune cytokine signaling192,025NIH's project files
R01AI127564Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis162,025NIH's project files
P20GM103408Idaho INBRE Program132,025NIH's project files
P50CA097190Head and Neck Cancer SPORE132,025NIH's project files
ZIAAR041159Cytokine Signaling, Immunoregulation and Autoimmune and Immunodeficiency Diseases132,025NIH's project files
P30CA016058Cancer Center Support Grant122,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant122,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award122,025NIH's project files

Papers 8953

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42807860PubTator, text miningPubMed
42805097PubTator, text miningPubMed
42800618PubTator, text miningPubMed
42793141PubTator, text miningPubMed
42774375PubTator, text miningPubMed
42765743PubTator, text miningPubMed
42758029PubTator, text miningPubMed
42750435PubTator, text miningPubMed
42737432PubTator, text miningPubMed
42723207PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license