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CXCR1: C-X-C motif chemokine receptor 1

1 protein, 144 patents, 5 drugs, 35 trials, 3,073 NIH grants and 5,562 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCXCR1HGNC
NameC-X-C motif chemokine receptor 1HGNC
NCBI Gene ID3577NCBI Gene
HGNC IDHGNC:6026HGNC
EnsemblENSG00000163464NCBI Gene
AliasesC-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBANCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P25024C-X-C chemokine receptor type 13505Ensembl, GeneID, HGNCUniProt

Patents 144

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026094314 A2026-06-0958P25024Espacenet
EP 4705273 A22026-03-11294P25024Espacenet
JP 2026021360 A2026-02-10149P25024Espacenet
JP 2026004568 A2026-01-1441092P25024Espacenet
EP 4640849 A22025-10-29471P25024Espacenet
EP 4641201 A22025-10-293230P25024Espacenet
EP 4641202 A22025-10-29190P25024Espacenet
JP 2025147176 A2025-10-0616709P25024Espacenet
JP 2025529142 A2025-09-041160P25024Espacenet
EP 4606428 A22025-08-2736P25024Espacenet

Drugs 5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
LADARIXINCHEMBL189475Interleukin-8 receptor A modulatorMODULATORChEMBL
NAVARIXINCHEMBL2103864Interleukin-8 receptor A antagonistANTAGONISTChEMBL
NAVARIXIN ANHYDROUSCHEMBL216981Interleukin-8 receptor A antagonistANTAGONISTChEMBL
REPARIXINCHEMBL191413Interleukin-8 receptor A modulatorMODULATORChEMBL
SX-682CHEMBL4297480Interleukin-8 receptors, CXCR1/CXCR2 inhibitorINHIBITORChEMBL

Trials 35

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07322341SX-682PHASE2ClinicalTrials.gov
NCT07002320SX-682PHASE1/PHASE2ClinicalTrials.gov
NCT06622005SX-682PHASE1ClinicalTrials.gov
NCT06228053SX-682PHASE2ClinicalTrials.gov
NCT06149481SX-682PHASE1/PHASE2ClinicalTrials.gov
NCT05835466REPARIXINPHASE2ClinicalTrials.gov
NCT05815186LADARIXINPHASE2ClinicalTrials.gov
NCT05815173LADARIXINPHASE1ClinicalTrials.gov
NCT05604560SX-682PHASE2ClinicalTrials.gov
NCT05570825SX-682PHASE2ClinicalTrials.gov

NIH grants 3073

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant232,025NIH's project files
P30CA008748Cancer Center Support Grant142,025NIH's project files
P30CA036727Buffett Cancer Center Support Grant132,025NIH's project files
P30CA068485Cancer Center Support Grant102,025NIH's project files
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)92,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202882,025NIH's project files
ZIAAI000615Molecular Analysis Of Leukocyte Activation By Chemoattractants72,025NIH's project files
P30CA047904Cancer Center Support Grant62,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases62,025NIH's project files
U54CA1186381/3 Morehouse School of Medicine/Tuskegee University/University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership62,025NIH's project files

Papers 5562

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42801784PubTator, text miningPubMed
42744872PubTator, text miningPubMed
42699267PubTator, text miningPubMed
42682451PubTator, text miningPubMed
42653415PubTator, text miningPubMed
42650137PubTator, text miningPubMed
42645633PubTator, text miningPubMed
42585215PubTator, text miningPubMed
42548795PubTator, text miningPubMed
42542174PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license