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CXCR2: C-X-C motif chemokine receptor 2

1 protein, 228 patents, 7 drugs, 46 trials, 5,367 NIH grants and 10,515 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCXCR2HGNC
NameC-X-C motif chemokine receptor 2HGNC
NCBI Gene ID3579NCBI Gene
HGNC IDHGNC:6027HGNC
EnsemblENSG00000180871NCBI Gene
AliasesCD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB, SCN13, WHIMS2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P25025C-X-C chemokine receptor type 236020Ensembl, GeneID, HGNCUniProt

Patents 228

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4805023 A12026-09-161P25025Espacenet
EP 4759370 A22026-06-1787P25025Espacenet
EP 4754236 A12026-06-101P25025Espacenet
JP 2026513144 A2026-04-2353P25025Espacenet
JP 2026062654 A2026-04-1030P25025Espacenet
EP 4705273 A22026-03-11295P25025Espacenet
EP 4678241 A22026-01-1448P25025Espacenet
EP 4641202 A22025-10-29279P25025Espacenet
JP 2025147176 A2025-10-0616710P25025Espacenet
WO 2025196207 A12025-09-2587P25025Espacenet

Drugs 7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DANIRIXINCHEMBL3039531Interleukin-8 receptor B antagonistANTAGONISTChEMBL
ELUBRIXINCHEMBL2178579Interleukin-8 receptor B antagonistANTAGONISTChEMBL
LADARIXINCHEMBL189475Interleukin-8 receptor B modulatorMODULATORChEMBL
NAVARIXINCHEMBL2103864Interleukin-8 receptor B antagonistANTAGONISTChEMBL
NAVARIXIN ANHYDROUSCHEMBL216981Interleukin-8 receptor B antagonistANTAGONISTChEMBL
REPARIXINCHEMBL191413Interleukin-8 receptor B modulatorMODULATORChEMBL
SX-682CHEMBL4297480Interleukin-8 receptors, CXCR1/CXCR2 inhibitorINHIBITORChEMBL

Trials 46

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07322341SX-682PHASE2ClinicalTrials.gov
NCT07002320SX-682PHASE1/PHASE2ClinicalTrials.gov
NCT06622005SX-682PHASE1ClinicalTrials.gov
NCT06228053SX-682PHASE2ClinicalTrials.gov
NCT06149481SX-682PHASE1/PHASE2ClinicalTrials.gov
NCT05835466REPARIXINPHASE2ClinicalTrials.gov
NCT05815186LADARIXINPHASE2ClinicalTrials.gov
NCT05815173LADARIXINPHASE1ClinicalTrials.gov
NCT05604560SX-682PHASE2ClinicalTrials.gov
NCT05570825SX-682PHASE2ClinicalTrials.gov

NIH grants 5367

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant502,025NIH's project files
P30CA068485Cancer Center Support Grant372,025NIH's project files
P30CA008748Cancer Center Support Grant312,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award212,025NIH's project files
P30CA036727Buffett Cancer Center Support Grant202,025NIH's project files
ZIAAI000615Molecular Analysis Of Leukocyte Activation By Chemoattractants142,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases132,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028122,025NIH's project files
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)112,025NIH's project files
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease112,025NIH's project files

Papers 10515

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824708PubTator, text miningPubMed
42794705PubTator, text miningPubMed
42794520PubTator, text miningPubMed
42792709PubTator, text miningPubMed
42780770PubTator, text miningPubMed
42780036PubTator, text miningPubMed
42779093PubTator, text miningPubMed
42777082PubTator, text miningPubMed
42769221PubTator, text miningPubMed
42767134PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license