Gene · 3587
IL10RA: interleukin 10 receptor subunit alpha
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IL10RA: interleukin 10 receptor subunit alpha. Genes, record 3587. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3587
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13651 | Interleukin-10 receptor subunit alpha | 578 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents83
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4705273 A2 | 2026-03-11 | 304 | Q13651 | Espacenet |
| EP 4688842 A1 | 2026-02-11 | 64 | Q13651 | Espacenet |
| US 12528850 B2 | 2026-01-20 | 52 | Q13651 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 50149 | Q13651 | Espacenet |
| EP 4653459 A1 | 2025-11-26 | 1 | Q13651 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 690 | Q13651 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 484 | Q13651 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 27 | Q13651 | Espacenet |
| EP 4641203 A2 | 2025-10-29 | 21 | Q13651 | Espacenet |
| EP 4633648 A1 | 2025-10-22 | 27 | Q13651 | Espacenet |
1 to 10 of 83
See all 83 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| PEGILODECAKIN | CHEMBL3989992 | IL-10 receptor agonist | AGONIST |
Source ChEMBL
Trials5
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT03554434 | PEGILODECAKIN | ClinicalTrials.gov | ||
| NCT03382912 | PEGILODECAKIN | PHASE2 | 2020-09-11 | ClinicalTrials.gov |
| NCT03382899 | PEGILODECAKIN | PHASE2 | 2021-01-20 | ClinicalTrials.gov |
| NCT02923921 | PEGILODECAKIN | PHASE3 | 2020-10-19 | ClinicalTrials.gov |
| NCT02009449 | PEGILODECAKIN | PHASE1 | ClinicalTrials.gov |
NIH grants2,537
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IL10RA papers | Newest fiscal year |
|---|---|---|---|
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 22 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 10 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| R01AI044938 | Inhibition of STAT3 and inflammatory cytokine production | 8 | 2025 |
| P30DK078392 | Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease | 7 | 2025 |
| P51OD011107 | California National Primate Research Center | 7 | 2025 |
| R01AI046712 | Activation of Macrophages in Human Autoimmune Diseases | 7 | 2025 |
| R01AR046713 | Cytokine regulation of RA synoviocyte phenotype | 7 | 2025 |
| RC2DK118640 | COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepository | 7 | 2025 |
| R01AR050401 | Cytokine Balance in Rheumatoid Arthritis | 6 | 2025 |
1 to 10 of 2,537Source NIH's project files
See all 2,537 nih grantsPapers3,503
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Identification of genetic variants associated with monogenic autoinflammatory diseases in patients with Still's disease using next-generation sequencing. | Immunol Res | 2026 | 42821198 | PubTator, text mining | PubMed |
| Targeting Mcl-1 to restore IL-10-driven Breg suppression reverses allergic asthma. | Immunol Lett | 2026 | 42810527 | PubTator, text mining | PubMed |
| In silico transcriptomic analysis nominates TSPAN32 as a central node of SCFA-driven immunometabolic reprogramming in intestinal epithelial cells. | Front Bioinform | 2026 | 42774375 | PubTator, text mining | PubMed |
| Clinical characteristics and prognosis of infant onset inflammatory bowel disease in Chinese children: a 10-year single-center experience. | Transl Pediatr | 2026 | 42724325 | PubTator, text mining | PubMed |
| Inflammatory Serum Olink Proteomics in Cancer-Related Pain Treated with Opioids: A Pilot Cross-Sectional and Longitudinal Study. | J Proteome Res | 2026 | 42695881 | PubTator, text mining | PubMed |
| Bioinformatics analysis reveals shared gene signatures and molecular mechanisms between periodontitis and rheumatoid arthritis in the context of aging. | Acta Odontol Scand | 2026 | 42627218 | PubTator, text mining | PubMed |
| Causal Effects of Circulating Inflammatory Proteins on Postmenopausal Atrophic Vaginitis in European Populations: A Mendelian Randomization Study with Transcriptomic Validation. | Int J Womens Health | 2026 | 42549019 | PubTator, text mining | PubMed |
| [Bidirectional two-sample MR analysis of causal relationships between human inflammatory proteins and HS and keloids]. | Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi | 2026 | 42547441 | PubTator, text mining | PubMed |
| Gamma Delta T Cells in Shrimp Allergy Express a Unique Cytotoxic Cytokine Profile. | Clin Transl Allergy | 2026 | 42533289 | PubTator, text mining | PubMed |
| Regulatory T cells establish an IL-10-IL10Rα immunometabolic checkpoint that limits HSL activation and lipolysis. | bioRxiv | 2026 | 42523439 | PubTator, text mining | PubMed |
1 to 10 of 3,503
See all 3,503 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3587
GET https://conductscience.org/api/genes/v1/3587/patents?page=2