Gene · 359
AQP2: aquaporin 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. AQP2: aquaporin 2. Genes, record 359. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/359
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P41181 | Aquaporin-2 | 271 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents35
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 37754 | P41181 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 428 | P41181 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 428 | P41181 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 5949 | P41181 | Espacenet |
| JP 2022547097 A | 2022-11-10 | 6 | P41181 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 5949 | P41181 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 137 | P41181 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 108920 | P41181 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 677 | P41181 | Espacenet |
| JP 2021081231 A | 2021-05-27 | 1 | P41181 | Espacenet |
1 to 10 of 35
See all 35 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,397
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | AQP2 papers | Newest fiscal year |
|---|---|---|---|
| ZIAHL001285 | Solute And Water Transport In Renal Epithelia | 60 | 2025 |
| ZIAHL006129 | Computational Tools for Proteomics | 38 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 27 | 2025 |
| R01DK096586 | Cell Biology of Vasopressin-induced Water Channels | 18 | 2025 |
| R01DK062794 | The role of the innate immune cell cyclooxygenase/prostaglandin system in blood pressureregulation | 7 | 2025 |
| R01DK104072 | Cloning and characterization of PRR24 as a specific renin receptor critically involved in vasopressin signaling in the kidney | 7 | 2025 |
| ZIGHL006020 | NHLBI Animal Program Division | 7 | 2025 |
| R01DK039773 | Mechanisms of Ischemic Kidney Injury and Repair | 5 | 2025 |
| R01DK064324 | Multiphoton imaging of the juxtaglomerular apparatus | 5 | 2025 |
| I01BX001000 | The Role of Intercalated Cells and Their Acid Base and Electrolyte Transport Machinery in Kidney Cystogenesis by Tuberous Sclerosis | 4 | 2025 |
1 to 10 of 1,397Source NIH's project files
See all 1,397 nih grantsPapers3,878
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Impact of fluconazole in vasopressin 2 receptor-related congenital arginine vasopressin resistance. | Kidney Int | 2026 | 42785711 | PubTator, text mining | PubMed |
| Large-scale organoid-derived cyst cultures as a drug discovery platform for polycystic kidney disease. | Kidney Int | 2026 | 42772449 | PubTator, text mining | PubMed |
An Exploratory Analysis of Potential Core Targets and Signaling Pathways Linking Dexmedetomidine to Diabetes Insipidus: Integration of FAERS Pharmacovigilance Data, Network Toxicology and Clinical Transcriptomics. | Drug Des Devel Ther | 2026 | 42769073 | PubTator, text mining | PubMed |
| Proteinuria is associated with a high abundance of urine extracellular vesicles from collecting duct principal cells. | Am J Physiol Renal Physiol | 2026 | 42629991 | PubTator, text mining | PubMed |
| Molecular Biomarkers in Meniere's Disease: A Scoping Review of Current Evidence. | Otolaryngol Head Neck Surg | 2026 | 42606302 | PubTator, text mining | PubMed |
| Lithium in Bipolar Disorder: Renal Mechanisms, Nephrotoxicity Phenotypes, and a Shared-Care Pathway for Clinical Practice. | Int J Mol Sci | 2026 | 42589388 | PubTator, text mining | PubMed |
| A clinical and experimental investigation of liraglutide effects on the brain-kidney axis. | Sci Adv | 2026 | 42555711 | PubTator, text mining | PubMed |
| Aquaporins 1, 2, 4, and 9 in gander testes throughout the annual period. | Theriogenology | 2026 | 42546530 | PubTator, text mining | PubMed |
| Genetic and biological mechanisms of pediatric enuresis: integrating pathophysiology, GWAS associations, and multi-omics research. | Eur J Pediatr | 2026 | 42484710 | PubTator, text mining | PubMed |
| Kinome-wide CRISPR/Cas9-knockout screening reveals critical protein kinases in vasopressin V2-receptor signaling. | bioRxiv | 2026 | 42465376 | PubTator, text mining | PubMed |
1 to 10 of 3,878
See all 3,878 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/359
GET https://conductscience.org/api/genes/v1/359/patents?page=2