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Gene · 359

AQP2: aquaporin 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. AQP2: aquaporin 2. Genes, record 359. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/359

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Gene

Symbol
AQP2
HGNC
Name
aquaporin 2
HGNC
NCBI Gene ID
359
NCBI Gene
HGNC ID
HGNC:634
HGNC
Ensembl
ENSG00000167580
NCBI Gene
Aliases
AQP-2, AQP-CD, NDI2, WCH-CD
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P41181Aquaporin-22717Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1437754P41181Espacenet
JP 2025529142 A2025-09-04428P41181Espacenet
US 12371689 B22025-07-29428P41181Espacenet
JP 2025062604 A2025-04-145949P41181Espacenet
JP 2022547097 A2022-11-106P41181Espacenet
US 11446398 B22022-09-205949P41181Espacenet
US 11400116 B22022-08-02137P41181Espacenet
JP 2022524081 A2022-04-27108920P41181Espacenet
US 11078247 B22021-08-03677P41181Espacenet
JP 2021081231 A2021-05-271P41181Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,397

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAQP2 papersNewest fiscal year
ZIAHL001285Solute And Water Transport In Renal Epithelia602025
ZIAHL006129Computational Tools for Proteomics382025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital272025
R01DK096586Cell Biology of Vasopressin-induced Water Channels182025
R01DK062794The role of the innate immune cell cyclooxygenase/prostaglandin system in blood pressureregulation72025
R01DK104072Cloning and characterization of PRR24 as a specific renin receptor critically involved in vasopressin signaling in the kidney72025
ZIGHL006020NHLBI Animal Program Division72025
R01DK039773Mechanisms of Ischemic Kidney Injury and Repair52025
R01DK064324Multiphoton imaging of the juxtaglomerular apparatus52025
I01BX001000The Role of Intercalated Cells and Their Acid Base and Electrolyte Transport Machinery in Kidney Cystogenesis by Tuberous Sclerosis42025

1 to 10 of 1,397Source NIH's project files

See all 1,397 nih grants

Papers3,878

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Impact of fluconazole in vasopressin 2 receptor-related congenital arginine vasopressin resistance.Kidney Int202642785711PubTator, text miningPubMed
Large-scale organoid-derived cyst cultures as a drug discovery platform for polycystic kidney disease.Kidney Int202642772449PubTator, text miningPubMed
An Exploratory Analysis of Potential Core Targets and Signaling Pathways Linking Dexmedetomidine to Diabetes Insipidus: Integration of FAERS Pharmacovigilance Data, Network Toxicology and Clinical Transcriptomics.
Drug Des Devel Ther202642769073PubTator, text miningPubMed
Proteinuria is associated with a high abundance of urine extracellular vesicles from collecting duct principal cells.Am J Physiol Renal Physiol202642629991PubTator, text miningPubMed
Molecular Biomarkers in Meniere's Disease: A Scoping Review of Current Evidence.Otolaryngol Head Neck Surg202642606302PubTator, text miningPubMed
Lithium in Bipolar Disorder: Renal Mechanisms, Nephrotoxicity Phenotypes, and a Shared-Care Pathway for Clinical Practice.Int J Mol Sci202642589388PubTator, text miningPubMed
A clinical and experimental investigation of liraglutide effects on the brain-kidney axis.Sci Adv202642555711PubTator, text miningPubMed
Aquaporins 1, 2, 4, and 9 in gander testes throughout the annual period.Theriogenology202642546530PubTator, text miningPubMed
Genetic and biological mechanisms of pediatric enuresis: integrating pathophysiology, GWAS associations, and multi-omics research.Eur J Pediatr202642484710PubTator, text miningPubMed
Kinome-wide CRISPR/Cas9-knockout screening reveals critical protein kinases in vasopressin V2-receptor signaling.bioRxiv202642465376PubTator, text miningPubMed

1 to 10 of 3,878

See all 3,878 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/359

GET https://conductscience.org/api/genes/v1/359/patents?page=2