Gene · 3590
IL11RA: interleukin 11 receptor subunit alpha
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IL11RA: interleukin 11 receptor subunit alpha. Genes, record 3590. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3590
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q14626 | Interleukin-11 receptor subunit alpha | 422 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents181
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026139590 A | 2026-09-01 | 1 | Q14626 | Espacenet |
| JP 2026134215 A | 2026-08-20 | 1 | Q14626 | Espacenet |
| WO 2026167137 A1 | 2026-08-13 | 1 | Q14626 | Espacenet |
| EP 4705273 A2 | 2026-03-11 | 297 | Q14626 | Espacenet |
| JP 2026503272 A | 2026-01-28 | 257 | Q14626 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 50153 | Q14626 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 50155 | Q14626 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 50156 | Q14626 | Espacenet |
| WO 2025255483 A2 | 2025-12-11 | 84 | Q14626 | Espacenet |
| WO 2025255486 A2 | 2025-12-11 | 84 | Q14626 | Espacenet |
1 to 10 of 181
See all 181 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| OPRELVEKIN | CHEMBL1201573 | Interleukin 11 receptor alpha agonist | AGONIST |
Source ChEMBL
Trials11
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07362810 | OPRELVEKIN | PHASE2 | ClinicalTrials.gov | |
| NCT02281240 | OPRELVEKIN | ClinicalTrials.gov | ||
| NCT02241031 | OPRELVEKIN | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT00994929 | OPRELVEKIN | PHASE2 | 2016-03-02 | ClinicalTrials.gov |
| NCT00524342 | OPRELVEKIN | PHASE2 | 2014-11-07 | ClinicalTrials.gov |
| NCT00524225 | OPRELVEKIN | PHASE2 | 2014-11-07 | ClinicalTrials.gov |
| NCT00493181 | OPRELVEKIN | PHASE2 | 2011-05-04 | ClinicalTrials.gov |
| NCT00151125 | OPRELVEKIN | PHASE2 | ClinicalTrials.gov | |
| NCT00040521 | OPRELVEKIN | PHASE2 | ClinicalTrials.gov | |
| NCT00012298 | OPRELVEKIN | PHASE1/PHASE2 | 2015-12-17 | ClinicalTrials.gov |
1 to 10 of 11
See all 11 trialsNIH grants507
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IL11RA papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| R01AI127564 | Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis | 5 | 2025 |
| P20GM130423 | The Kansas Institute for Precision Medicine | 2 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 2 | 2025 |
| P30CA118100 | University of New Mexico Cancer Center Support Grant | 2 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 2 | 2025 |
| P30DK034987 | Center for Gastrointestinal Biology and Disease | 2 | 2025 |
| P50CA126752 | SPORE in Lymphoma | 2 | 2025 |
| R01AI051321 | Structure-based engineering of immune cytokine signaling | 2 | 2025 |
1 to 10 of 507Source NIH's project files
See all 507 nih grantsPapers741
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Peripheral Blood Immunogenomic Cytokine-receptor Signature (CXCR1, IL11RA, IL13RA2, CD19) Predicts HBV-related Cirrhosis: Public PBMC Transcriptome Mining and Nomogram Development. | Iran J Allergy Asthma Immunol | 2026 | 42801784 | PubTator, text mining | PubMed |
| Interleukin-11 Signaling in Liver Disease: Mechanisms, Cellular Crosstalk, and Therapeutic Potential. | Biomolecules | 2026 | 42793141 | PubTator, text mining | PubMed |
| Novel IL11RA Compound Heterozygous Variants in a Chinese Pediatric Patient With Pancraniosynostosis. | J Craniofac Surg | 2026 | 42627986 | PubTator, text mining | PubMed |
| Exploring Targets for Heart Failure Using Mendelian Randomization, Colocalization, Summary Data-based Mendelian Randomization, and Drug Prediction. | J Vis Exp | 2026 | 42507612 | PubTator, text mining | PubMed |
| Synthesis of Gd-DOTA-BMTP and its application in gadolinium neutron capture therapy for osteosarcoma. | J Cancer Res Clin Oncol | 2026 | 42313263 | PubTator, text mining | PubMed |
| IL11 modulates MMP12 expression and cancer cell metastasis via IL11RA/IL6ST-PI3K/Akt/NF-κB pathway in lung cancer. | Cell Death Discov | 2026 | 42276992 | PubTator, text mining | PubMed |
| The Clinical and Molecular Spectrum of Turkish Patients with Syndromic Craniosynostosis: A Single Center Study. | Turk Arch Pediatr | 2026 | 42084887 | PubTator, text mining | PubMed |
| Non-linear age-related change in human Interleukin-11 and the receptor subunit alpha DNA methylation. | Biochem Biophys Rep | 2026 | 41909151 | PubTator, text mining | PubMed |
| The Heterogeneity and Function of Stromal Cells in the Tumor Microenvironment. | Research (Wash D C) | 2026 | 41809407 | PubTator, text mining | PubMed |
| Mechanistic insights into inflammatory cytokines in adenomyosis‑induced infertility (Review). | Int J Mol Med | 2026 | 41789648 | PubTator, text mining | PubMed |
1 to 10 of 741
See all 741 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3590
GET https://conductscience.org/api/genes/v1/3590/patents?page=2