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Gene · 3590

IL11RA: interleukin 11 receptor subunit alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IL11RA: interleukin 11 receptor subunit alpha. Genes, record 3590. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3590

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Gene

Symbol
IL11RA
HGNC
Name
interleukin 11 receptor subunit alpha
HGNC
NCBI Gene ID
3590
NCBI Gene
HGNC ID
HGNC:5967
HGNC
Ensembl
ENSG00000137070
NCBI Gene
Aliases
CRSDA
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14626Interleukin-11 receptor subunit alpha4225Ensembl, GeneID, HGNC

Source UniProt

Patents181

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026139590 A2026-09-011Q14626Espacenet
JP 2026134215 A2026-08-201Q14626Espacenet
WO 2026167137 A12026-08-131Q14626Espacenet
EP 4705273 A22026-03-11297Q14626Espacenet
JP 2026503272 A2026-01-28257Q14626Espacenet
JP 2026004568 A2026-01-1450153Q14626Espacenet
JP 2026004568 A2026-01-1450155Q14626Espacenet
JP 2026004568 A2026-01-1450156Q14626Espacenet
WO 2025255483 A22025-12-1184Q14626Espacenet
WO 2025255486 A22025-12-1184Q14626Espacenet

1 to 10 of 181

See all 181 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
OPRELVEKINCHEMBL1201573Interleukin 11 receptor alpha agonistAGONIST

Source ChEMBL

Trials11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07362810OPRELVEKINPHASE2ClinicalTrials.gov
NCT02281240OPRELVEKINClinicalTrials.gov
NCT02241031OPRELVEKINPHASE2/PHASE3ClinicalTrials.gov
NCT00994929OPRELVEKINPHASE22016-03-02ClinicalTrials.gov
NCT00524342OPRELVEKINPHASE22014-11-07ClinicalTrials.gov
NCT00524225OPRELVEKINPHASE22014-11-07ClinicalTrials.gov
NCT00493181OPRELVEKINPHASE22011-05-04ClinicalTrials.gov
NCT00151125OPRELVEKINPHASE2ClinicalTrials.gov
NCT00040521OPRELVEKINPHASE2ClinicalTrials.gov
NCT00012298OPRELVEKINPHASE1/PHASE22015-12-17ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

NIH grants507

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIL11RA papersNewest fiscal year
P30CA016672Cancer Center Support Grant92025
P30CA008748Cancer Center Support Grant62025
R01AI127564Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis52025
P20GM130423The Kansas Institute for Precision Medicine22025
P30CA021765Cancer Center Support Grant (CCSG)22025
P30CA118100University of New Mexico Cancer Center Support Grant22025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant22025
P30DK034987Center for Gastrointestinal Biology and Disease22025
P50CA126752SPORE in Lymphoma22025
R01AI051321Structure-based engineering of immune cytokine signaling22025

1 to 10 of 507Source NIH's project files

See all 507 nih grants

Papers741

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Peripheral Blood Immunogenomic Cytokine-receptor Signature (CXCR1, IL11RA, IL13RA2, CD19) Predicts HBV-related Cirrhosis: Public PBMC Transcriptome Mining and Nomogram Development.Iran J Allergy Asthma Immunol202642801784PubTator, text miningPubMed
Interleukin-11 Signaling in Liver Disease: Mechanisms, Cellular Crosstalk, and Therapeutic Potential.Biomolecules202642793141PubTator, text miningPubMed
Novel IL11RA Compound Heterozygous Variants in a Chinese Pediatric Patient With Pancraniosynostosis.J Craniofac Surg202642627986PubTator, text miningPubMed
Exploring Targets for Heart Failure Using Mendelian Randomization, Colocalization, Summary Data-based Mendelian Randomization, and Drug Prediction.J Vis Exp202642507612PubTator, text miningPubMed
Synthesis of Gd-DOTA-BMTP and its application in gadolinium neutron capture therapy for osteosarcoma.J Cancer Res Clin Oncol202642313263PubTator, text miningPubMed
IL11 modulates MMP12 expression and cancer cell metastasis via IL11RA/IL6ST-PI3K/Akt/NF-κB pathway in lung cancer.Cell Death Discov202642276992PubTator, text miningPubMed
The Clinical and Molecular Spectrum of Turkish Patients with Syndromic Craniosynostosis: A Single Center Study.Turk Arch Pediatr202642084887PubTator, text miningPubMed
Non-linear age-related change in human Interleukin-11 and the receptor subunit alpha DNA methylation.Biochem Biophys Rep202641909151PubTator, text miningPubMed
The Heterogeneity and Function of Stromal Cells in the Tumor Microenvironment.Research (Wash D C)202641809407PubTator, text miningPubMed
Mechanistic insights into inflammatory cytokines in adenomyosis‑induced infertility (Review).Int J Mol Med202641789648PubTator, text miningPubMed

1 to 10 of 741

See all 741 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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