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IL12B: interleukin 12B

1 protein, 645 patents, 11 drugs, 380 trials, 20,833 NIH grants and 67,481 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIL12BHGNC
Nameinterleukin 12BHGNC
NCBI Gene ID3593NCBI Gene
HGNC IDHGNC:5970HGNC
EnsemblENSG00000113302NCBI Gene
AliasesCLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P29460Interleukin-12 subunit beta32820Ensembl, GeneID, HGNCUniProt

Patents 645

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4791437 A12026-08-19160P29460Espacenet
EP 4774003 A12026-07-152P29460Espacenet
EP 4774398 A12026-07-1561P29460Espacenet
EP 4757832 A12026-06-17213P29460Espacenet
JP 2026086743 A2026-05-26144P29460Espacenet
JP 2026082822 A2026-05-193P29460Espacenet
US 12630625 B22026-05-1975P29460Espacenet
US 12617829 B22026-05-0574P29460Espacenet
US 12617829 B22026-05-0578P29460Espacenet
JP 2026074006 A2026-05-0125P29460Espacenet

Drugs 11

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BRAZIKUMABCHEMBL3833372Interleukin-23 inhibitorINHIBITORChEMBL
BRIAKINUMABCHEMBL1742995Interleukin-23 inhibitorINHIBITORChEMBL
BRIAKINUMABCHEMBL1742995Interleukin-12 inhibitorINHIBITORChEMBL
EBDAROKIMABCHEMBL4650437Interleukin-12 inhibitorINHIBITORChEMBL
EBDAROKIMABCHEMBL4650437Interleukin-23 inhibitorINHIBITORChEMBL
GUSELKUMABCHEMBL2364648Interleukin-23 inhibitorINHIBITORChEMBL
MIRIKIZUMABCHEMBL3990014Interleukin-23 inhibitorINHIBITORChEMBL
RISANKIZUMABCHEMBL3990029Interleukin-23 inhibitorINHIBITORChEMBL
TILDRAKIZUMABCHEMBL2108681Interleukin-23 inhibitorINHIBITORChEMBL
USTEKINUMABCHEMBL1201835Interleukin-23 inhibitorINHIBITORChEMBL

Trials 380

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07582991USTEKINUMABPHASE2ClinicalTrials.gov
NCT07577856GUSELKUMABPHASE3ClinicalTrials.gov
NCT07545317GUSELKUMABClinicalTrials.gov
NCT07545317RISANKIZUMABClinicalTrials.gov
NCT07532486GUSELKUMABClinicalTrials.gov
NCT07529236USTEKINUMABClinicalTrials.gov
NCT07528040GUSELKUMABClinicalTrials.gov
NCT07499232GUSELKUMABPHASE3ClinicalTrials.gov
NCT07499232RISANKIZUMABPHASE3ClinicalTrials.gov
NCT07495644USTEKINUMABClinicalTrials.gov

NIH grants 20833

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1812,025NIH's project files
P30CA016672Cancer Center Support Grant1632,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program932,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award902,025NIH's project files
P30CA016058Cancer Center Support Grant802,025NIH's project files
P30CA047904Cancer Center Support Grant652,025NIH's project files
ZIAAI000647Genes And Gene Products As Immunoadjuvants652,025NIH's project files
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success552,025NIH's project files
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital492,025NIH's project files
P30CA006973Regional Oncology Research Center482,025NIH's project files

Papers 67481

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824708PubTator, text miningPubMed
42822323PubTator, text miningPubMed
42818629PubTator, text miningPubMed
42817702PubTator, text miningPubMed
42817032PubTator, text miningPubMed
42813654PubTator, text miningPubMed
42811155PubTator, text miningPubMed
42810409PubTator, text miningPubMed
42806985PubTator, text miningPubMed
42806636PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license