Gene · 3594
IL12RB1: interleukin 12 receptor subunit beta 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IL12RB1: interleukin 12 receptor subunit beta 1. Genes, record 3594. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3594
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P42701 | Interleukin-12 receptor subunit beta-1 | 662 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents251
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4795154 A1 | 2026-08-26 | 127 | P42701 | Espacenet |
| JP 2026082822 A | 2026-05-19 | 5 | P42701 | Espacenet |
| US 12617829 B2 | 2026-05-05 | 77 | P42701 | Espacenet |
| JP 2026048631 A | 2026-03-17 | 177 | P42701 | Espacenet |
| EP 4705273 A2 | 2026-03-11 | 302 | P42701 | Espacenet |
| EP 4705273 A2 | 2026-03-11 | 393 | P42701 | Espacenet |
| JP 2026504906 A | 2026-02-10 | 12 | P42701 | Espacenet |
| JP 2026016843 A | 2026-02-03 | 55 | P42701 | Espacenet |
| US 12528850 B2 | 2026-01-20 | 67 | P42701 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 50160 | P42701 | Espacenet |
1 to 10 of 251
See all 251 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,527
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IL12RB1 papers | Newest fiscal year |
|---|---|---|---|
| UL1TR001866 | Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success | 28 | 2025 |
| ZIAAI000647 | Genes And Gene Products As Immunoadjuvants | 27 | 2025 |
| ZIAAI000646 | Transgenic Animal Models Of Human Immune Defects | 15 | 2025 |
| R01AI127564 | Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis | 14 | 2025 |
| R01AI095983 | Genome-Wide Dissection of Mendelian Susceptibility to Mycobacterial Disease | 11 | 2025 |
| ZIAAI001122 | Studies of Inherited Causes of Fungal Susceptability | 11 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 10 | 2025 |
| ZIACL010304 | Mutation Analysis Of Selected Lymphoid Immune Disorders | 9 | 2025 |
| R01AI163029 | Inborn errors of immunity in patients with life-threatening COVID-19 | 7 | 2025 |
| R01AI051321 | Structure-based engineering of immune cytokine signaling | 6 | 2025 |
1 to 10 of 1,527Source NIH's project files
See all 1,527 nih grantsPapers2,084
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Diet-responsive proteogenomic effects following short-term restriction of animal products in humans. | Nat Commun | 2026 | 42706243 | PubTator, text mining | PubMed |
| Reduction of CXCR3+CCR6+ CD4+ T Cells and IL-17+ RORγt+ CD4+ T Cells During Secukinumab Treatment Identifies Patients With Axial Spondyloarthritis Responsive to Subsequent Biologic Therapy. | ACR Open Rheumatol | 2026 | 42666100 | PubTator, text mining | PubMed |
| LncRNA-miRNA-mRNA Regulatory Network Reveals Potential Immune Responses in Larval Tomato Hind (Cephalopholis sonnerati) Infected with RGNNV. | Biology (Basel) | 2026 | 42651684 | PubTator, text mining | PubMed |
| Persistent Ascites Revealing Mendelian Susceptibility to Mycobacterial Disease Due to IL-12Rβ1 Deficiency: A Case Report and Review of the Literature. | Case Reports Immunol | 2026 | 42643649 | PubTator, text mining | PubMed |
| Obstructive Cholestasis in IL12RB1 Deficiency: A Case Report of an Unusual Hepatobiliary Presentation in Mendelian Susceptibility to Mycobacterial Disease. | Case Rep Pediatr | 2026 | 42548864 | PubTator, text mining | PubMed |
| Patients with Crohn's Disease Achieving Ustekinumab-Induced Remission Are Characterized by Increased Baseline IL-23 Receptor Expression on Lamina Propria Th1 Cells. | J Clin Med | 2026 | 42513348 | PubTator, text mining | PubMed |
| IL-12p40 drives oral squamous cell carcinoma progression via MMPs and IL-12Rβ1/STAT3 signaling. | Cancer Cell Int | 2026 | 42464274 | PubTator, text mining | PubMed |
| Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis. | J Exp Med | 2026 | 42424313 | PubTator, text mining | PubMed |
| Henoch-Schoenlein purpura-like lesions in IL12RB1 and IL12B defects-a multi-centric experience from India. | Clin Exp Immunol | 2026 | 42366588 | PubTator, text mining | PubMed |
| In Silico Identification and Structural Characterization of High-Risk Missense SNVs in the Human IL23R Gene Relevant to Inflammatory Bowel Disease. | Genes (Basel) | 2026 | 42353858 | PubTator, text mining | PubMed |
1 to 10 of 2,084
See all 2,084 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3594
GET https://conductscience.org/api/genes/v1/3594/patents?page=2