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Gene · 3594

IL12RB1: interleukin 12 receptor subunit beta 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IL12RB1: interleukin 12 receptor subunit beta 1. Genes, record 3594. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3594

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Gene

Symbol
IL12RB1
HGNC
Name
interleukin 12 receptor subunit beta 1
HGNC
NCBI Gene ID
3594
NCBI Gene
HGNC ID
HGNC:5971
HGNC
Ensembl
ENSG00000096996
NCBI Gene
Aliases
CD212, IL-12R-BETA1, IL12RB, IMD30
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P42701Interleukin-12 receptor subunit beta-16627Ensembl, GeneID, HGNC

Source UniProt

Patents251

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4795154 A12026-08-26127P42701Espacenet
JP 2026082822 A2026-05-195P42701Espacenet
US 12617829 B22026-05-0577P42701Espacenet
JP 2026048631 A2026-03-17177P42701Espacenet
EP 4705273 A22026-03-11302P42701Espacenet
EP 4705273 A22026-03-11393P42701Espacenet
JP 2026504906 A2026-02-1012P42701Espacenet
JP 2026016843 A2026-02-0355P42701Espacenet
US 12528850 B22026-01-2067P42701Espacenet
JP 2026004568 A2026-01-1450160P42701Espacenet

1 to 10 of 251

See all 251 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,527

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIL12RB1 papersNewest fiscal year
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success282025
ZIAAI000647Genes And Gene Products As Immunoadjuvants272025
ZIAAI000646Transgenic Animal Models Of Human Immune Defects152025
R01AI127564Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis142025
R01AI095983Genome-Wide Dissection of Mendelian Susceptibility to Mycobacterial Disease112025
ZIAAI001122Studies of Inherited Causes of Fungal Susceptability112025
P30CA008748Cancer Center Support Grant102025
ZIACL010304Mutation Analysis Of Selected Lymphoid Immune Disorders92025
R01AI163029Inborn errors of immunity in patients with life-threatening COVID-1972025
R01AI051321Structure-based engineering of immune cytokine signaling62025

1 to 10 of 1,527Source NIH's project files

See all 1,527 nih grants

Papers2,084

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Diet-responsive proteogenomic effects following short-term restriction of animal products in humans.Nat Commun202642706243PubTator, text miningPubMed
Reduction of CXCR3+CCR6+ CD4+ T Cells and IL-17+ RORγt+ CD4+ T Cells During Secukinumab Treatment Identifies Patients With Axial Spondyloarthritis Responsive to Subsequent Biologic Therapy.ACR Open Rheumatol202642666100PubTator, text miningPubMed
LncRNA-miRNA-mRNA Regulatory Network Reveals Potential Immune Responses in Larval Tomato Hind (Cephalopholis sonnerati) Infected with RGNNV.Biology (Basel)202642651684PubTator, text miningPubMed
Persistent Ascites Revealing Mendelian Susceptibility to Mycobacterial Disease Due to IL-12Rβ1 Deficiency: A Case Report and Review of the Literature.Case Reports Immunol202642643649PubTator, text miningPubMed
Obstructive Cholestasis in IL12RB1 Deficiency: A Case Report of an Unusual Hepatobiliary Presentation in Mendelian Susceptibility to Mycobacterial Disease.Case Rep Pediatr202642548864PubTator, text miningPubMed
Patients with Crohn's Disease Achieving Ustekinumab-Induced Remission Are Characterized by Increased Baseline IL-23 Receptor Expression on Lamina Propria Th1 Cells.J Clin Med202642513348PubTator, text miningPubMed
IL-12p40 drives oral squamous cell carcinoma progression via MMPs and IL-12Rβ1/STAT3 signaling.Cancer Cell Int202642464274PubTator, text miningPubMed
Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis.J Exp Med202642424313PubTator, text miningPubMed
Henoch-Schoenlein purpura-like lesions in IL12RB1 and IL12B defects-a multi-centric experience from India.Clin Exp Immunol202642366588PubTator, text miningPubMed
In Silico Identification and Structural Characterization of High-Risk Missense SNVs in the Human IL23R Gene Relevant to Inflammatory Bowel Disease.Genes (Basel)202642353858PubTator, text miningPubMed

1 to 10 of 2,084

See all 2,084 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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