ConductScience.org, home

Gene · 3595

IL12RB2: interleukin 12 receptor subunit beta 2

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. IL12RB2: interleukin 12 receptor subunit beta 2. Genes, record 3595. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3595

On this page

Gene

Symbol
IL12RB2
HGNC
Name
interleukin 12 receptor subunit beta 2
HGNC
NCBI Gene ID
3595
NCBI Gene
HGNC ID
HGNC:5972
HGNC
Ensembl
ENSG00000081985
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99665Interleukin-12 receptor subunit beta-28622Ensembl, GeneID, HGNC

Source UniProt

Patents183

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026082822 A2026-05-197Q99665Espacenet
US 12617829 B22026-05-0576Q99665Espacenet
JP 2026048631 A2026-03-17178Q99665Espacenet
EP 4705273 A22026-03-11301Q99665Espacenet
EP 4705273 A22026-03-11394Q99665Espacenet
JP 2026504906 A2026-02-1013Q99665Espacenet
JP 2026016843 A2026-02-0354Q99665Espacenet
JP 2026004568 A2026-01-1450163Q99665Espacenet
US 12522638 B22026-01-13135Q99665Espacenet
JP 2025172069 A2025-11-20105Q99665Espacenet

1 to 10 of 183

See all 183 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,539

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIL12RB2 papersNewest fiscal year
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success132025
P30CA008748Cancer Center Support Grant112025
R01AI051321Structure-based engineering of immune cytokine signaling82025
R01AI095983Genome-Wide Dissection of Mendelian Susceptibility to Mycobacterial Disease72025
ZIAEY000350Development of Immunologic therapies against uveitis62025
P01AI039671Costimulatory Mechanisms of Autoimmunity52025
R01AI127564Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis52025
U01DK062422Mount Sinai NYC Genetics Research Center: Multi-omic integration across data-types, cell niches and populations52025
ZIAEY000262Role of IL-12 family cytokines in autoimmune Uveitis52025
ZIAEY000372Mechanisms of immune homeostasis and regulation of intraocular inflammation52025

1 to 10 of 1,539Source NIH's project files

See all 1,539 nih grants

Papers1,950

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Age-related changes of FCGR3A+ natural killer cells and their association with elderly atopic dermatitis.EBioMedicine202642771994PubTator, text miningPubMed
Real-world insights into genomic reprogramming during CAR-T cell manufacturing in India.Front Immunol202642756106PubTator, text miningPubMed
Dose-Dependent Alterations in Lung Immune Subpopulations in Influenza a Virus Infection.Int J Mol Sci202642737426PubTator, text miningPubMed
Patients with Crohn's Disease Achieving Ustekinumab-Induced Remission Are Characterized by Increased Baseline IL-23 Receptor Expression on Lamina Propria Th1 Cells.J Clin Med202642513348PubTator, text miningPubMed
IL-12Rβ2 is Expressed in the Synthetic SMC and Detected in the Blood of Patients With Acute Myocardial Infarction.Korean Circ J202642438249PubTator, text miningPubMed
Genetic mechanisms of primary biliary cholangitis and its association with immune cells using mendelian randomization and biological annotation.Medicine (Baltimore)202642216402PubTator, text miningPubMed
Sex-specific autosomal susceptibility loci in systemic sclerosis: a genome-wide association study.Lancet Rheumatol202641999721PubTator, text miningPubMed
Immunological dysfunction associated with SARS-CoV-2 persistence in immunocompromised patients.Clin Exp Immunol202641961589PubTator, text miningPubMed
Primary biliary cirrhosis and rheumatoid arthritis: a comprehensive study combining genetics and transcriptomics.Mamm Genome202641942635PubTator, text miningPubMed
An Immunomodulating Peptide With Potential to Counteract Endometriosis.Aust N Z J Obstet Gynaecol202641913689PubTator, text miningPubMed

1 to 10 of 1,950

See all 1,950 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3595

GET https://conductscience.org/api/genes/v1/3595/patents?page=2