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Gene · 3598

IL13RA2: interleukin 13 receptor subunit alpha 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IL13RA2: interleukin 13 receptor subunit alpha 2. Genes, record 3598. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3598

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Gene

Symbol
IL13RA2
HGNC
Name
interleukin 13 receptor subunit alpha 2
HGNC
NCBI Gene ID
3598
NCBI Gene
HGNC ID
HGNC:5975
HGNC
Ensembl
ENSG00000123496
NCBI Gene
Aliases
CD213A2, CD213a2, CT19, IL-13R, IL13BP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14627Interleukin-13 receptor subunit alpha-23801Ensembl, GeneID, HGNC

Source UniProt

Patents207

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12636345 B22026-05-262Q14627Espacenet
EP 4705273 A22026-03-11299Q14627Espacenet
EP 4705273 A22026-03-11400Q14627Espacenet
JP 2026004568 A2026-01-1450171Q14627Espacenet
JP 2026004568 A2026-01-1450172Q14627Espacenet
EP 4650780 A22025-11-191083Q14627Espacenet
EP 4641201 A22025-10-29761Q14627Espacenet
JP 2025147176 A2025-10-0616676Q14627Espacenet
JP 2025529142 A2025-09-042073Q14627Espacenet
EP 4606428 A22025-08-2716Q14627Espacenet

1 to 10 of 207

See all 207 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
CINTREDEKIN BESUDOTOXCHEMBL2108583Interleukin-13 receptor subunit alpha-2 binding agentBINDING AGENT

Source ChEMBL

Trials9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT00880061CINTREDEKIN BESUDOTOXPHASE1ClinicalTrials.gov
NCT00378235CINTREDEKIN BESUDOTOXPHASE1/PHASE2ClinicalTrials.gov
NCT00089427CINTREDEKIN BESUDOTOXPHASE1ClinicalTrials.gov
NCT00076986CINTREDEKIN BESUDOTOXPHASE3ClinicalTrials.gov
NCT00053040CINTREDEKIN BESUDOTOXPHASE1/PHASE2ClinicalTrials.gov
NCT00041587CINTREDEKIN BESUDOTOXPHASE1/PHASE2ClinicalTrials.gov
NCT00036972CINTREDEKIN BESUDOTOXPHASE1ClinicalTrials.gov
NCT00024570CINTREDEKIN BESUDOTOXPHASE1/PHASE2ClinicalTrials.gov
NCT00024557CINTREDEKIN BESUDOTOXPHASE1ClinicalTrials.gov

NIH grants1,705

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIL13RA2 papersNewest fiscal year
P30CA033572Cancer Center Support Grant282025
P30CA008748Cancer Center Support Grant142025
T32HL092332Training In Cell and Gene Therapy132025
P30CA016672Cancer Center Support Grant112025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant112025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease102025
R35NS105068Preclinical development of breakthrough immunotherapy for brain tumors102025
P30CA012197Cancer Center Support Grant92025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center82025
P50CA221747SPORE for Translational Approaches to Brain Cancer82025

1 to 10 of 1,705Source NIH's project files

See all 1,705 nih grants

Papers2,877

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Chimeric Antigen Receptor T Cell Therapy for Glioblastoma: Clinical Advances and Emerging Strategies.Hematol Oncol Clin North Am202642816201PubTator, text miningPubMed
Peripheral Blood Immunogenomic Cytokine-receptor Signature (CXCR1, IL11RA, IL13RA2, CD19) Predicts HBV-related Cirrhosis: Public PBMC Transcriptome Mining and Nomogram Development.Iran J Allergy Asthma Immunol202642801784PubTator, text miningPubMed
Payload-Free Epitope Imprinted Polymer Nanoparticles Selectively Targeting IL-13Rα2 and Inhibition of Diffuse Midline Glioma Cells.Cancers (Basel)202642794993PubTator, text miningPubMed
BRD4 contributes to the cytokine-induced acquisition of an IL-13RA2-positive inflammatory fibroblast phenotype.J Crohns Colitis202642635600PubTator, text miningPubMed
Upadacitinib effectively suppresses IL13RA2 expression in primary human intestinal fibroblasts derived from Crohn's disease tissue.Biochem Pharmacol202642603621PubTator, text miningPubMed
Context-dependent promotion of epithelial-mesenchymal transition by IL-13Rα2/STAT6 signaling in colorectal cancer.Mol Cell Biochem202642573974PubTator, text miningPubMed
CAR T-cell therapy in pediatric brain tumors: a narrative review with comparative analysis of clinical trial eligibility criteria.Front Oncol202642568366PubTator, text miningPubMed
Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy.Adv Sci (Weinh)202642554595PubTator, text miningPubMed
Phase I Trial of IL13Rα2-Targeted CAR T-cell Therapy for Recurrent Malignant Glioma: Clinical Results and Pharmacokinetics.Clin Cancer Res202642550847PubTator, text miningPubMed
EGFR inhibition promotes functional engraftment and graft survival via donor-derived CHI3L1 in fetal RPE suspension transplantation.Cell Rep Med202642546699PubTator, text miningPubMed

1 to 10 of 2,877

See all 2,877 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3598

GET https://conductscience.org/api/genes/v1/3598/patents?page=2