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TNFRSF9: TNF receptor superfamily member 9

1 protein, 1,008 patents, 2 drugs, 25 trials, 4,928 NIH grants and 11,479 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTNFRSF9HGNC
NameTNF receptor superfamily member 9HGNC
NCBI Gene ID3604NCBI Gene
HGNC IDHGNC:11924HGNC
EnsemblENSG00000049249NCBI Gene
Aliases4-1BB, CD137, CDw137, ILA, IMD109NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q07011Tumor necrosis factor receptor superfamily member 925514Ensembl, GeneID, HGNCUniProt

Patents 1008

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026222276 A12026-10-2241Q07011Espacenet
WO 2026189672 A12026-09-1762Q07011Espacenet
WO 2026190350 A12026-09-1762Q07011Espacenet
EP 4806462 A22026-09-165Q07011Espacenet
EP 4801643 A12026-09-0943Q07011Espacenet
EP 4801963 A12026-09-09139Q07011Espacenet
WO 2026183237 A12026-09-0340Q07011Espacenet
WO 2026183388 A12026-09-03678Q07011Espacenet
EP 4795154 A12026-08-2623Q07011Espacenet
EP 4763220 A22026-06-24122Q07011Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
URELUMABCHEMBL1743085Tumor necrosis factor receptor superfamily member 9 agonistAGONISTChEMBL
UTOMILUMABCHEMBL3707324Tumor necrosis factor receptor superfamily member 9 agonistAGONISTChEMBL

Trials 25

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03636503UTOMILUMABPHASE12025-02-06ClinicalTrials.gov
NCT03440567UTOMILUMABPHASE1ClinicalTrials.gov
NCT03414658UTOMILUMABPHASE22024-04-18ClinicalTrials.gov
NCT03364348UTOMILUMABPHASE12022-10-19ClinicalTrials.gov
NCT03318900UTOMILUMABPHASE1/PHASE22024-11-07ClinicalTrials.gov
NCT03290937UTOMILUMABPHASE1ClinicalTrials.gov
NCT03258008UTOMILUMABPHASE22022-12-16ClinicalTrials.gov
NCT03217747UTOMILUMABPHASE1/PHASE22025-10-14ClinicalTrials.gov
NCT02951156UTOMILUMABPHASE32020-12-17ClinicalTrials.gov
NCT02845323URELUMABPHASE2ClinicalTrials.gov

NIH grants 4928

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1752,025NIH's project files
P30CA016672Cancer Center Support Grant1242,025NIH's project files
P50CA126752SPORE in Lymphoma542,025NIH's project files
P30CA016520Abramson Cancer Center Support Grant472,025NIH's project files
ZIABC010984Adoptive Cell Transfer Immunotherapy of Cancer432,025NIH's project files
P30CA006973Regional Oncology Research Center392,025NIH's project files
P30CA047904Cancer Center Support Grant342,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant322,025NIH's project files
P30CA016042Cancer Center Support Grant312,025NIH's project files
P30CA033572Cancer Center Support Grant312,025NIH's project files

Papers 11479

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42819567PubTator, text miningPubMed
42804151PubTator, text miningPubMed
42800817PubTator, text miningPubMed
42776797PubTator, text miningPubMed
42760117PubTator, text miningPubMed
42742874PubTator, text miningPubMed
42723279PubTator, text miningPubMed
42722105PubTator, text miningPubMed
42695609PubTator, text miningPubMed
42688568PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license