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IL18: interleukin 18

1 protein, 352 patents, 3 drugs, 13 trials, 14,125 NIH grants and 44,078 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIL18HGNC
Nameinterleukin 18HGNC
NCBI Gene ID3606NCBI Gene
HGNC IDHGNC:5986HGNC
EnsemblENSG00000150782NCBI Gene
AliasesIGIF, IL-18, IL-1g, IL1F4NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q14116Interleukin-1819320Ensembl, GeneID, HGNCUniProt

Patents 352

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026210341 A12026-10-0862Q14116Espacenet
EP 4795154 A12026-08-26121Q14116Espacenet
EP 4795155 A12026-08-2629Q14116Espacenet
EP 4791437 A12026-08-19171Q14116Espacenet
EP 4774398 A12026-07-1558Q14116Espacenet
EP 4757832 A12026-06-17400Q14116Espacenet
EP 4754236 A12026-06-1073Q14116Espacenet
JP 2026517179 A2026-05-286Q14116Espacenet
JP 2026086743 A2026-05-26117Q14116Espacenet
JP 2026082951 A2026-05-1913Q14116Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CAMOTESKIMABCHEMBL2109604Interleukin-18 cross-linking agentCROSS-LINKING AGENTChEMBL
GSK-1070806CHEMBL2109606Interleukin-18 inhibitorINHIBITORChEMBL
TADEKINIG ALFACHEMBL2108054Interleukin-18 inhibitorINHIBITORChEMBL

Trials 13

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07599813CAMOTESKIMABPHASE2ClinicalTrials.gov
NCT06447506GSK-1070806PHASE2ClinicalTrials.gov
NCT06436183CAMOTESKIMABPHASE2ClinicalTrials.gov
NCT05999799GSK-1070806PHASE2ClinicalTrials.gov
NCT04975438GSK-1070806PHASE12024-07-23ClinicalTrials.gov
NCT04752371CAMOTESKIMABPHASE1ClinicalTrials.gov
NCT04671251CAMOTESKIMABPHASE1ClinicalTrials.gov
NCT03681067GSK-1070806PHASE1/PHASE2ClinicalTrials.gov
NCT03522662GSK-1070806PHASE2ClinicalTrials.gov
NCT03512314TADEKINIG ALFAPHASE3ClinicalTrials.gov

NIH grants 14125

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant952,025NIH's project files
R01AI015614Pathogenesis of Fever in Man922,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award852,025NIH's project files
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation602,025NIH's project files
R01AI124346Innate immune signaling and stress response562,025NIH's project files
P30CA016672Cancer Center Support Grant402,025NIH's project files
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies362,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant352,025NIH's project files
P51OD011104Tulane National Primate Research Center292,025NIH's project files
P01CA111412NK cells, their receptors and cancer therapy282,025NIH's project files

Papers 44078

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825916PubTator, text miningPubMed
42823398PubTator, text miningPubMed
42822323PubTator, text miningPubMed
42820090PubTator, text miningPubMed
42818906PubTator, text miningPubMed
42812611PubTator, text miningPubMed
42811258PubTator, text miningPubMed
42806587PubTator, text miningPubMed
42806287PubTator, text miningPubMed
42805516PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license