Gene · 3614
IMPDH1: inosine monophosphate dehydrogenase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IMPDH1: inosine monophosphate dehydrogenase 1. Genes, record 3614. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3614
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P20839 | Inosine-5'-monophosphate dehydrogenase 1 | 514 | 18 | Ensembl, GeneID, HGNC |
Source UniProt
Patents5
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
Drugs9
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AVN-944 | CHEMBL3349001 | Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor | INHIBITOR | ChEMBL |
| MERIMEPODIB | CHEMBL304087 | Inosine-5'-monophosphate dehydrogenase 1 inhibitor | INHIBITOR | ChEMBL |
| MIZORIBINE | CHEMBL245019 | Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor | INHIBITOR | ChEMBL |
| MYCOPHENOLATE MOFETIL | CHEMBL1456 | Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor | INHIBITOR | ChEMBL |
| MYCOPHENOLATE MOFETIL HYDROCHLORIDE | CHEMBL1200955 | Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor | INHIBITOR | ChEMBL |
| MYCOPHENOLATE SODIUM | CHEMBL2106643 | Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor | INHIBITOR | ChEMBL |
| MYCOPHENOLIC ACID | CHEMBL866 | Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor | INHIBITOR | ChEMBL |
| RIBAVIRIN | CHEMBL1643 | Inosine-5'-monophosphate dehydrogenase 1 inhibitor | INHIBITOR | ChEMBL |
| THIOGUANINE | CHEMBL727 | Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor | INHIBITOR | ChEMBL |
Trials1,195
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07605364 | MYCOPHENOLATE MOFETIL | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07566377 | MYCOPHENOLATE MOFETIL | PHASE2 | ClinicalTrials.gov | |
| NCT07548983 | MYCOPHENOLATE MOFETIL | PHASE1 | ClinicalTrials.gov | |
| NCT07519005 | MYCOPHENOLATE MOFETIL | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07491523 | MYCOPHENOLATE MOFETIL | ClinicalTrials.gov | ||
| NCT07419373 | RIBAVIRIN | PHASE2 | ClinicalTrials.gov | |
| NCT07340463 | MYCOPHENOLATE MOFETIL | PHASE2 | ClinicalTrials.gov | |
| NCT07162038 | MYCOPHENOLATE MOFETIL | PHASE1 | ClinicalTrials.gov | |
| NCT07108530 | MYCOPHENOLATE MOFETIL | PHASE2 | ClinicalTrials.gov | |
| NCT07072585 | THIOGUANINE | PHASE2/PHASE3 | ClinicalTrials.gov |
1 to 10 of 1,195
See all 1,195 trialsNIH grants720
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IMPDH1 papers | Newest fiscal year |
|---|---|---|---|
| R01EY018571 | Genetics of early onset retinal diseases | 7 | 2025 |
| ZIAEY000272 | Inherited Ocular Diseases | 6 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 5 | 2025 |
| R01EY018213 | Defining Barriers to Gene Therapy | 5 | 2025 |
| R01EY022356 | Molecular Basis of Human Visual System Disorders | 5 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30ES019776 | HERCULES: Exposome Research Center | 4 | 2025 |
| P30EY014104 | P30 Core Grant for Vision Research | 4 | 2025 |
| R01EY012910 | Precision Medicine for Inherited Retinal Degenerations | 4 | 2025 |
1 to 10 of 720Source NIH's project files
See all 720 nih grantsPapers894
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Dietary Polyphenol Acteoside-Related Molecular Signatures in Clear Cell Renal Cell Carcinoma: Multi-Omics Profiling and Functional Validation of IMPDH1. | Food Sci Nutr | 2026 | 42694600 | PubTator, text mining | PubMed |
| Genomic diversification between aposematic and cryptic phenotypes of Oophaga granulifera (Anura: Dendrobatidae). | Sci Rep | 2026 | 42661044 | PubTator, text mining | PubMed |
| Selectively targeting inosine monophosphate dehydrogenase-2 impairs brain metastatic potential while preserving immune cell function. | Proc Natl Acad Sci U S A | 2026 | 42308042 | PubTator, text mining | PubMed |
| Aimed at Subtype Discrimination but Yielding a Shared Marker: Integrative Analysis of Blood Transcriptomes Reveals Upregulated TLR5 as a Potential Biomarker for IBD. | Clin Exp Gastroenterol | 2026 | 42112146 | PubTator, text mining | PubMed |
| A prognostic model based on nucleotide metabolism genes in osteosarcoma. | Discov Oncol | 2026 | 42069976 | PubTator, text mining | PubMed |
| IMPDH1 is a potential immune evasion-related oncoprotein in endometrial cancer. | BMC Genom Data | 2026 | 42062899 | PubTator, text mining | PubMed |
| Grape seed proanthocyanidin extract suppresses bladder cancer by dual blockade of IMPDH1/2-mediated purine and pyrimidine nucleotide biosynthesis. | J Ethnopharmacol | 2026 | 41962611 | PubTator, text mining | PubMed |
| Molecular mechanisms in podocytopathies: finding suitable targets for a new era of glomerular gene therapy. | Clin Kidney J | 2026 | 41788620 | PubTator, text mining | PubMed |
| Assessment of In-Frame Indel Variants in an Unsolved Cohort of Inherited Retinal Diseases Using Machine Learning. | Hum Mutat | 2026 | 41777615 | PubTator, text mining | PubMed |
| Bioinformatics Identification and Functional Analysis of Key Genes of Nucleotide Metabolism in Oral Squamous Cell Carcinoma. | Oral Health Prev Dent | 2026 | 41733601 | PubTator, text mining | PubMed |
1 to 10 of 894
See all 894 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3614
GET https://conductscience.org/api/genes/v1/3614/trials?page=2