ConductScience.org, home

Gene · 3614

IMPDH1: inosine monophosphate dehydrogenase 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. IMPDH1: inosine monophosphate dehydrogenase 1. Genes, record 3614. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3614

On this page

Gene

Symbol
IMPDH1
HGNC
Name
inosine monophosphate dehydrogenase 1
HGNC
NCBI Gene ID
3614
NCBI Gene
HGNC ID
HGNC:6052
HGNC
Ensembl
ENSG00000106348
NCBI Gene
Aliases
IMPD, IMPD1, IMPDH-I, LCA11, RP10, sWSS2608
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P20839Inosine-5'-monophosphate dehydrogenase 151418Ensembl, GeneID, HGNC

Source UniProt

Patents5

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2020043864 A12020-03-051209P20839Espacenet
US 9290773 B22016-03-2218813P20839Espacenet
JP 2004514409 A2004-05-2062P20839Espacenet
WO 02068649 A22002-09-06764P20839Espacenet
WO 0185952 A22001-11-1562P20839Espacenet

Drugs9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AVN-944CHEMBL3349001Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitorINHIBITORChEMBL
MERIMEPODIBCHEMBL304087Inosine-5'-monophosphate dehydrogenase 1 inhibitorINHIBITORChEMBL
MIZORIBINECHEMBL245019Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitorINHIBITORChEMBL
MYCOPHENOLATE MOFETILCHEMBL1456Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitorINHIBITORChEMBL
MYCOPHENOLATE MOFETIL HYDROCHLORIDECHEMBL1200955Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitorINHIBITORChEMBL
MYCOPHENOLATE SODIUMCHEMBL2106643Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitorINHIBITORChEMBL
MYCOPHENOLIC ACIDCHEMBL866Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitorINHIBITORChEMBL
RIBAVIRINCHEMBL1643Inosine-5'-monophosphate dehydrogenase 1 inhibitorINHIBITORChEMBL
THIOGUANINECHEMBL727Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitorINHIBITORChEMBL

Trials1,195

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605364MYCOPHENOLATE MOFETILPHASE2/PHASE3ClinicalTrials.gov
NCT07566377MYCOPHENOLATE MOFETILPHASE2ClinicalTrials.gov
NCT07548983MYCOPHENOLATE MOFETILPHASE1ClinicalTrials.gov
NCT07519005MYCOPHENOLATE MOFETILEARLY_PHASE1ClinicalTrials.gov
NCT07491523MYCOPHENOLATE MOFETILClinicalTrials.gov
NCT07419373RIBAVIRINPHASE2ClinicalTrials.gov
NCT07340463MYCOPHENOLATE MOFETILPHASE2ClinicalTrials.gov
NCT07162038MYCOPHENOLATE MOFETILPHASE1ClinicalTrials.gov
NCT07108530MYCOPHENOLATE MOFETILPHASE2ClinicalTrials.gov
NCT07072585THIOGUANINEPHASE2/PHASE3ClinicalTrials.gov

1 to 10 of 1,195

See all 1,195 trials

NIH grants720

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIMPDH1 papersNewest fiscal year
R01EY018571Genetics of early onset retinal diseases72025
ZIAEY000272Inherited Ocular Diseases62025
P30CA006927Comprehensive Cancer Center Program at Fox Chase52025
R01EY018213Defining Barriers to Gene Therapy52025
R01EY022356Molecular Basis of Human Visual System Disorders52025
P30CA016056Roswell Park Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
P30ES019776HERCULES: Exposome Research Center42025
P30EY014104P30 Core Grant for Vision Research42025
R01EY012910Precision Medicine for Inherited Retinal Degenerations42025

1 to 10 of 720Source NIH's project files

See all 720 nih grants

Papers894

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Dietary Polyphenol Acteoside-Related Molecular Signatures in Clear Cell Renal Cell Carcinoma: Multi-Omics Profiling and Functional Validation of IMPDH1.Food Sci Nutr202642694600PubTator, text miningPubMed
Genomic diversification between aposematic and cryptic phenotypes of Oophaga granulifera (Anura: Dendrobatidae).Sci Rep202642661044PubTator, text miningPubMed
Selectively targeting inosine monophosphate dehydrogenase-2 impairs brain metastatic potential while preserving immune cell function.Proc Natl Acad Sci U S A202642308042PubTator, text miningPubMed
Aimed at Subtype Discrimination but Yielding a Shared Marker: Integrative Analysis of Blood Transcriptomes Reveals Upregulated TLR5 as a Potential Biomarker for IBD.Clin Exp Gastroenterol202642112146PubTator, text miningPubMed
A prognostic model based on nucleotide metabolism genes in osteosarcoma.Discov Oncol202642069976PubTator, text miningPubMed
IMPDH1 is a potential immune evasion-related oncoprotein in endometrial cancer.BMC Genom Data202642062899PubTator, text miningPubMed
Grape seed proanthocyanidin extract suppresses bladder cancer by dual blockade of IMPDH1/2-mediated purine and pyrimidine nucleotide biosynthesis.J Ethnopharmacol202641962611PubTator, text miningPubMed
Molecular mechanisms in podocytopathies: finding suitable targets for a new era of glomerular gene therapy.Clin Kidney J202641788620PubTator, text miningPubMed
Assessment of In-Frame Indel Variants in an Unsolved Cohort of Inherited Retinal Diseases Using Machine Learning.Hum Mutat202641777615PubTator, text miningPubMed
Bioinformatics Identification and Functional Analysis of Key Genes of Nucleotide Metabolism in Oral Squamous Cell Carcinoma.Oral Health Prev Dent202641733601PubTator, text miningPubMed

1 to 10 of 894

See all 894 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3614

GET https://conductscience.org/api/genes/v1/3614/trials?page=2