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Gene · 3615

IMPDH2: inosine monophosphate dehydrogenase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IMPDH2: inosine monophosphate dehydrogenase 2. Genes, record 3615. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3615

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Gene

Symbol
IMPDH2
HGNC
Name
inosine monophosphate dehydrogenase 2
HGNC
NCBI Gene ID
3615
NCBI Gene
HGNC ID
HGNC:6053
HGNC
Ensembl
ENSG00000178035
NCBI Gene
Aliases
IMPD2, IMPDH-II
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P12268Inosine-5'-monophosphate dehydrogenase 251425Ensembl, GeneID, HGNC

Source UniProt

Patents57

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449697P12268Espacenet
EP 4650780 A22025-11-195384P12268Espacenet
EP 4641202 A22025-10-294953P12268Espacenet
JP 2025517970 A2025-06-125384P12268Espacenet
JP 2025038035 A2025-03-184389P12268Espacenet
KR 1020250017231 A2025-02-044953P12268Espacenet
US 12134655 B22024-11-054389P12268Espacenet
US 11446398 B22022-09-2040031P12268Espacenet
JP 2022530667 A2022-06-304389P12268Espacenet
JP 2022524081 A2022-04-27143002P12268Espacenet

1 to 10 of 57

See all 57 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AVN-944CHEMBL3349001Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitorINHIBITORChEMBL
MIZORIBINECHEMBL245019Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitorINHIBITORChEMBL
MYCOPHENOLATE MOFETILCHEMBL1456Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitorINHIBITORChEMBL
MYCOPHENOLATE MOFETIL HYDROCHLORIDECHEMBL1200955Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitorINHIBITORChEMBL
MYCOPHENOLATE SODIUMCHEMBL2106643Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitorINHIBITORChEMBL
MYCOPHENOLIC ACIDCHEMBL866Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitorINHIBITORChEMBL
THIOGUANINECHEMBL727Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitorINHIBITORChEMBL

Trials511

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605364MYCOPHENOLATE MOFETILPHASE2/PHASE3ClinicalTrials.gov
NCT07566377MYCOPHENOLATE MOFETILPHASE2ClinicalTrials.gov
NCT07548983MYCOPHENOLATE MOFETILPHASE1ClinicalTrials.gov
NCT07519005MYCOPHENOLATE MOFETILEARLY_PHASE1ClinicalTrials.gov
NCT07491523MYCOPHENOLATE MOFETILClinicalTrials.gov
NCT07340463MYCOPHENOLATE MOFETILPHASE2ClinicalTrials.gov
NCT07162038MYCOPHENOLATE MOFETILPHASE1ClinicalTrials.gov
NCT07108530MYCOPHENOLATE MOFETILPHASE2ClinicalTrials.gov
NCT07072585THIOGUANINEPHASE2/PHASE3ClinicalTrials.gov
NCT07059156MYCOPHENOLATE MOFETILPHASE2/PHASE3ClinicalTrials.gov

1 to 10 of 511

See all 511 trials

NIH grants811

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIMPDH2 papersNewest fiscal year
P01AI063302The intersection of innate and adaptive immunity to intracellular pathogens42025
P30CA006927Comprehensive Cancer Center Program at Fox Chase42025
P30CA008748Cancer Center Support Grant42025
P30CA016056Roswell Park Cancer Center Support Grant42025
U19AI135972SARS-CoV adaptations through a Systems Biology Lens (SYBIL)42025
U19AI135990HPMI: Host Pathogen Mapping Initiative42025
P01CA018029Adult Leukemia Research Center32025
P01CA078902Preventing Relapse After Non-myeloablative Stem Cell Transplantation: The Final Challenge32025
P30CA016672Cancer Center Support Grant32025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202832025

1 to 10 of 811Source NIH's project files

See all 811 nih grants

Papers1,079

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PSMD14 as a translational target in cancer and beyond: from deubiquitination mechanisms to drug resistance and precision therapy.Cancer Drug Resist202642729688PubTator, text miningPubMed
Targeting IMPDH2 by Casticin attenuates psoriatic inflammation by suppressing STAT3 activation in keratinocytes.Int Immunopharmacol202642567108PubTator, text miningPubMed
MMF inhibits poxvirus infection by disrupting IMPDH2 interaction with USP5 and inducing its rod-and-ring assemblies.Virol Sin202642492700PubTator, text miningPubMed
Mitochondrial metabolism-associated biomarkers in oral lichen planus and oral squamous cell carcinoma.Funct Integr Genomics202642418018PubTator, text miningPubMed
Cytosolic EZH2-IMPDH2 complexes regulate melanoma progression and metastasis via GTP.Mol Cell202642392044PubTator, text miningPubMed
Selectively targeting inosine monophosphate dehydrogenase-2 impairs brain metastatic potential while preserving immune cell function.Proc Natl Acad Sci U S A202642308042PubTator, text miningPubMed
Exploring the Toxicological Impact and Mechanisms of DEHP Exposure on Prostate Cancer Through Network Toxicology and Machine Learning Algorithms.Curr Med Chem202642304923PubTator, text miningPubMed
Grape seed proanthocyanidin extract suppresses bladder cancer by dual blockade of IMPDH1/2-mediated purine and pyrimidine nucleotide biosynthesis.J Ethnopharmacol202641962611PubTator, text miningPubMed
USP5 regulates purine metabolism and represents a therapeutic target in esophageal cancer.Cell Death Dis202641922317PubTator, text miningPubMed
Expanding the targeted protein degradation approach with small molecule chimeras directed to the 26S proteasome.Nat Commun202641904120PubTator, text miningPubMed

1 to 10 of 1,079

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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