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Gene · 362

AQP5: aquaporin 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. AQP5: aquaporin 5. Genes, record 362. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/362

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Gene

Symbol
AQP5
HGNC
Name
aquaporin 5
HGNC
NCBI Gene ID
362
NCBI Gene
HGNC ID
HGNC:638
HGNC
Ensembl
ENSG00000161798
NCBI Gene
Aliases
AQP-5, PPKB
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P55064Aquaporin-52654Ensembl, GeneID, HGNC

Source UniProt

Patents44

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025169942 A2025-11-14821P55064Espacenet
JP 2025529142 A2025-09-04431P55064Espacenet
US 12371689 B22025-07-29431P55064Espacenet
JP 2025062604 A2025-04-145959P55064Espacenet
US 11446398 B22022-09-205959P55064Espacenet
US 11400116 B22022-08-022425P55064Espacenet
JP 2022524081 A2022-04-27108930P55064Espacenet
US 11078247 B22021-08-03680P55064Espacenet
US 10772975 B22020-09-15821P55064Espacenet
EP 3611183 A12020-02-198P55064Espacenet

1 to 10 of 44

See all 44 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,123

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAQP5 papersNewest fiscal year
R01EY013462The Role of Aquaporins in Lens Structure and Function172025
ZIADE000704Clinical and Mechanistic Investigations of Salivary Gland Dysfunction122025
P30EY008126Core Grant in Vision Research82025
ZIADE000438Molecular Mechanisms Regulating Calcium Flux In Salivary Glands82025
ZIADE000695Adeno-associated Virus Biology And Utilization For Gene Transfer82025
R01DE022971THE USE OF FIBRIN HYDROGELS TO PROMOTE SALIVARY GLAND REGENERATION72025
R01DK101332Induction and Evolution of Metaplasia in the Stomach72025
I01BX000930Oxyntic Atrophy and Novel Gastric Lineages.62025
P30CA068485Cancer Center Support Grant62025
P30DK058404Molecular and Cellular Basis for Digestive Diseases62025

1 to 10 of 1,123Source NIH's project files

See all 1,123 nih grants

Papers2,670

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Immunohistochemical cerebral cortex expression of aquaporin 4, aquaporin 5, aquaporin 9 Vasopressin and GFAP in saltwater drowning and freshwater drowning.Int J Legal Med202642771035PubTator, text miningPubMed
Assessment of Salivary Flow Patterns in Sjögren's Disease.Oral Dis202642764807PubTator, text miningPubMed
The expression of stemness markers in organoids according to histological subtypes of gastric cancer.Korean J Clin Oncol202642687517PubTator, text miningPubMed
Dynamic Changes in Serum Aquaporin-1 and Aquaporin-5 in Transient Tachypnea of the Newborn.Int J Mol Sci202642653248PubTator, text miningPubMed
Incomplete Intestinal Metaplasia as a High-Risk Clinical Phenotype in Gastric Carcinogenesis: Implications for Surveillance and Management.Digestion202642611800PubTator, text miningPubMed
Aquaporin 5 and Nuclear Factor Erythroid 2-Related Factor 2 Upregulation in Tumor and Stroma Is Associated with Poor Pathological Complete Response to Neoadjuvant Chemotherapy in Breast Cancer.Med Princ Pract202642574300PubTator, text miningPubMed
Senescent Alveolospheres: A Preliminary 3D Model for Exploring Epithelial Senescence and Pro-Fibrotic Signaling.Int J Mol Sci202642511519PubTator, text miningPubMed
Lute-Gen® Alleviates Dry Eye Disease and Modulates Nrf2/HO-1, TLR4/NF-κB/MAPK Signaling, and Aquaporin-Mediated Tear Homeostasis.Antioxidants (Basel)202642510603PubTator, text miningPubMed
Retraction notice to "Development of novel prognostic protein signatures in ovarian cancer: Molecular structure and immune function of AQP5 protein and CTDP1 protein" [Int. J. Biol. Macromol. 310 (2025) 143474].
Int J Biol Macromol202642486759PubTator, text miningPubMed
Evaluation of pilocarpine effects on sweat proteome.J Proteomics202642437570PubTator, text miningPubMed

1 to 10 of 2,670

See all 2,670 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/362

GET https://conductscience.org/api/genes/v1/362/patents?page=2