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IDO1: indoleamine 2,3-dioxygenase 1

1 protein, 124 patents, 2 drugs, 65 trials, 6,880 NIH grants and 20,692 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIDO1HGNC
Nameindoleamine 2,3-dioxygenase 1HGNC
NCBI Gene ID3620NCBI Gene
HGNC IDHGNC:6059HGNC
EnsemblENSG00000131203NCBI Gene
AliasesIDO, IDO-1, INDONCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P14902Indoleamine 2,3-dioxygenase 140385Ensembl, GeneID, HGNCUniProt

Patents 124

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026171886 A12026-08-204P14902Espacenet
WO 2026143086 A12026-07-0226P14902Espacenet
EP 4750891 A12026-06-03117P14902Espacenet
JP 2026044603 A2026-03-122P14902Espacenet
JP 2026004568 A2026-01-1449731P14902Espacenet
JP 2026004568 A2026-01-1449734P14902Espacenet
EP 4641201 A22025-10-2918303P14902Espacenet
EP 4641202 A22025-10-297500P14902Espacenet
JP 2025147176 A2025-10-0614702P14902Espacenet
JP 2025517969 A2025-06-1218303P14902Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EPACADOSTATCHEMBL3545369Indoleamine 2,3-dioxygenase inhibitorINHIBITORChEMBL
LINRODOSTATCHEMBL4297598Indoleamine 2,3-dioxygenase inhibitorINHIBITORChEMBL

Trials 65

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07490002EPACADOSTATPHASE2ClinicalTrials.gov
NCT04586244EPACADOSTATPHASE22025-03-10ClinicalTrials.gov
NCT04463771EPACADOSTATPHASE2ClinicalTrials.gov
NCT04231864EPACADOSTATPHASE2ClinicalTrials.gov
NCT04106414LINRODOSTATPHASE2ClinicalTrials.gov
NCT04047706LINRODOSTATPHASE1ClinicalTrials.gov
NCT04007588LINRODOSTATPHASE2ClinicalTrials.gov
NCT03854032LINRODOSTATPHASE2ClinicalTrials.gov
NCT03832673EPACADOSTATPHASE2ClinicalTrials.gov
NCT03823131EPACADOSTATPHASE22023-05-09ClinicalTrials.gov

NIH grants 6880

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1072,025NIH's project files
P30CA016672Cancer Center Support Grant912,025NIH's project files
P30CA006973Regional Oncology Research Center362,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award332,025NIH's project files
P30CA047904Cancer Center Support Grant282,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant222,025NIH's project files
P30AI027763UCSF-Bay Area Center for AIDS Research212,025NIH's project files
R01NS097851IDO1 and Immunotolerance in Glioblastoma212,025NIH's project files
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies192,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program192,025NIH's project files

Papers 20692

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42815525PubTator, text miningPubMed
42809307PubTator, text miningPubMed
42806046PubTator, text miningPubMed
42803175PubTator, text miningPubMed
42800423PubTator, text miningPubMed
42799794PubTator, text miningPubMed
42787737PubTator, text miningPubMed
42787680PubTator, text miningPubMed
42786817PubTator, text miningPubMed
42779970PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license