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Gene · 3635

INPP5D: inositol polyphosphate-5-phosphatase D

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. INPP5D: inositol polyphosphate-5-phosphatase D. Genes, record 3635. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3635

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Gene

Symbol
INPP5D
HGNC
Name
inositol polyphosphate-5-phosphatase D
HGNC
NCBI Gene ID
3635
NCBI Gene
HGNC ID
HGNC:6079
HGNC
Ensembl
ENSG00000168918
NCBI Gene
Aliases
SHIP, SHIP-1, SHIP1, SIP-145, hp51CN, p150Ship
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92835Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 11,18999Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026013165 A12026-01-153Q92835Espacenet
EP 4640849 A22025-10-292313Q92835Espacenet
EP 4641201 A22025-10-2915168Q92835Espacenet
JP 2025519096 A2025-06-242313Q92835Espacenet
JP 2025517969 A2025-06-1215168Q92835Espacenet
US 12285484 B22025-04-29281Q92835Espacenet
JP 2025062601 A2025-04-1417Q92835Espacenet
JP 2025032204 A2025-03-1129976Q92835Espacenet
JP 2025032204 A2025-03-1129981Q92835Espacenet
EP 4461818 A22024-11-1329976Q92835Espacenet

1 to 10 of 28

See all 28 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
ROSIPTORCHEMBL3989954Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 activatorACTIVATOR

Source ChEMBL

Trials5

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03500159ROSIPTORPHASE22019-01-09ClinicalTrials.gov
NCT02858453ROSIPTORPHASE3ClinicalTrials.gov
NCT02324972ROSIPTORPHASE22018-10-05ClinicalTrials.gov
NCT01954628ROSIPTORPHASE22017-06-12ClinicalTrials.gov
NCT01882543ROSIPTORPHASE22017-09-05ClinicalTrials.gov

NIH grants3,016

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleINPP5D papersNewest fiscal year
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)322025
P30CA016672Cancer Center Support Grant152025
P30CA016058Cancer Center Support Grant142025
P30DK063491Diabetes Research Center (DRC)142025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions122025
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study102025
P30CA008748Cancer Center Support Grant102025
R01NS017950Precursors of Stroke Incidence and Prognosis82025
U24AG041689THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITE82025
U24AG056270National Institute on Aging Alzheimer's Disease Family-Based Study (NIA-AD FBS)82025

1 to 10 of 3,016Source NIH's project files

See all 3,016 nih grants

Papers3,499

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrative transcriptomic and regulatory network analysis reveals associations of seven proposed risk genes with immune-related molecular features in Alzheimer's disease.J Alzheimers Dis202642813688PubTator, text miningPubMed
Systemic immune programming in the life course of childhood asthma: a new perspective on monocyte pre-activation and trained immunity.Front Immunol202642812887PubTator, text miningPubMed
Multi-omics analysis identifies macrophage immunometabolic signatures in ulcerative colitis.Front Cell Infect Microbiol202642755516PubTator, text miningPubMed
Changes in Ocean Heat, Carbon Content, Ventilation, and Biology: A Review of the Second Decade of GO-SHIP Global Repeat Hydrography.Ann Rev Mar Sci202642748191PubTator, text miningPubMed
Let-7a-5p/SHIP-1 Axis Drives SARS-CoV-2 Spike-1-Induced Microglial Pyroptosis.Int J Mol Sci202642737767PubTator, text miningPubMed
Describing behavioral aspects of annual lung cancer screening participation: Application of the cognitive-social health information processing model.Prev Oncol Epidemiol202642666880PubTator, text miningPubMed
Decitabine Reprograms Temozolomide-Resistant Glioblastoma Through Epigenetic Reactivation and Mesenchymal Attenuation: A Multi-Omics Study.Cancers (Basel)202642649932PubTator, text miningPubMed
CD22 regulates Aβ clearance in microglia through INPP5D signaling.Front Cell Neurosci202642582107PubTator, text miningPubMed
11-deoxycortisol, other hormones and pituitary function characteristics in the diagnosis of adrenal insufficiency in the overnight oral metyrapone test.Endocr Connect202642525124PubTator, text miningPubMed
Determinants of Reclassification of Exercise Performance across Cardiopulmonary Exercise Testing Prediction Equations.Med Sci Sports Exerc202642492489PubTator, text miningPubMed

1 to 10 of 3,499

See all 3,499 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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