Gene · 3635
INPP5D: inositol polyphosphate-5-phosphatase D
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. INPP5D: inositol polyphosphate-5-phosphatase D. Genes, record 3635. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3635
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q92835 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | 1,189 | 99 | Ensembl, GeneID, HGNC |
Source UniProt
Patents28
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2026013165 A1 | 2026-01-15 | 3 | Q92835 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 2313 | Q92835 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 15168 | Q92835 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 2313 | Q92835 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 15168 | Q92835 | Espacenet |
| US 12285484 B2 | 2025-04-29 | 281 | Q92835 | Espacenet |
| JP 2025062601 A | 2025-04-14 | 17 | Q92835 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 29976 | Q92835 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 29981 | Q92835 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 29976 | Q92835 | Espacenet |
1 to 10 of 28
See all 28 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| ROSIPTOR | CHEMBL3989954 | Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 activator | ACTIVATOR |
Source ChEMBL
Trials5
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT03500159 | ROSIPTOR | PHASE2 | 2019-01-09 | ClinicalTrials.gov |
| NCT02858453 | ROSIPTOR | PHASE3 | ClinicalTrials.gov | |
| NCT02324972 | ROSIPTOR | PHASE2 | 2018-10-05 | ClinicalTrials.gov |
| NCT01954628 | ROSIPTOR | PHASE2 | 2017-06-12 | ClinicalTrials.gov |
| NCT01882543 | ROSIPTOR | PHASE2 | 2017-09-05 | ClinicalTrials.gov |
NIH grants3,016
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | INPP5D papers | Newest fiscal year |
|---|---|---|---|
| U24AG021886 | National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) | 32 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 15 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 14 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 14 | 2025 |
| P01AG019724 | Frontotemporal Dementia: Genes, Images, and Emotions | 12 | 2025 |
| P01AG026276 | Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study | 10 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 10 | 2025 |
| R01NS017950 | Precursors of Stroke Incidence and Prognosis | 8 | 2025 |
| U24AG041689 | THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITE | 8 | 2025 |
| U24AG056270 | National Institute on Aging Alzheimer's Disease Family-Based Study (NIA-AD FBS) | 8 | 2025 |
1 to 10 of 3,016Source NIH's project files
See all 3,016 nih grantsPapers3,499
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Integrative transcriptomic and regulatory network analysis reveals associations of seven proposed risk genes with immune-related molecular features in Alzheimer's disease. | J Alzheimers Dis | 2026 | 42813688 | PubTator, text mining | PubMed |
| Systemic immune programming in the life course of childhood asthma: a new perspective on monocyte pre-activation and trained immunity. | Front Immunol | 2026 | 42812887 | PubTator, text mining | PubMed |
| Multi-omics analysis identifies macrophage immunometabolic signatures in ulcerative colitis. | Front Cell Infect Microbiol | 2026 | 42755516 | PubTator, text mining | PubMed |
| Changes in Ocean Heat, Carbon Content, Ventilation, and Biology: A Review of the Second Decade of GO-SHIP Global Repeat Hydrography. | Ann Rev Mar Sci | 2026 | 42748191 | PubTator, text mining | PubMed |
| Let-7a-5p/SHIP-1 Axis Drives SARS-CoV-2 Spike-1-Induced Microglial Pyroptosis. | Int J Mol Sci | 2026 | 42737767 | PubTator, text mining | PubMed |
| Describing behavioral aspects of annual lung cancer screening participation: Application of the cognitive-social health information processing model. | Prev Oncol Epidemiol | 2026 | 42666880 | PubTator, text mining | PubMed |
| Decitabine Reprograms Temozolomide-Resistant Glioblastoma Through Epigenetic Reactivation and Mesenchymal Attenuation: A Multi-Omics Study. | Cancers (Basel) | 2026 | 42649932 | PubTator, text mining | PubMed |
| CD22 regulates Aβ clearance in microglia through INPP5D signaling. | Front Cell Neurosci | 2026 | 42582107 | PubTator, text mining | PubMed |
| 11-deoxycortisol, other hormones and pituitary function characteristics in the diagnosis of adrenal insufficiency in the overnight oral metyrapone test. | Endocr Connect | 2026 | 42525124 | PubTator, text mining | PubMed |
| Determinants of Reclassification of Exercise Performance across Cardiopulmonary Exercise Testing Prediction Equations. | Med Sci Sports Exerc | 2026 | 42492489 | PubTator, text mining | PubMed |
1 to 10 of 3,499
See all 3,499 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3635
GET https://conductscience.org/api/genes/v1/3635/patents?page=2