ConductScience.org, home

Library / Genes

INSR: insulin receptor

1 protein, 45 patents, 31 drugs, 1,844 trials, 11,713 NIH grants and 28,269 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolINSRHGNC
Nameinsulin receptorHGNC
NCBI Gene ID3643NCBI Gene
HGNC IDHGNC:6091HGNC
EnsemblENSG00000171105NCBI Gene
AliasesCD220, HHF5NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P06213Insulin receptor1,38293Ensembl, GeneID, HGNCUniProt

Patents 45

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026088136 A2026-05-282P06213Espacenet
EP 4684799 A22026-01-282P06213Espacenet
JP 2026004568 A2026-01-1449903P06213Espacenet
EP 4650780 A22025-11-194237P06213Espacenet
WO 2025235931 A22025-11-133P06213Espacenet
EP 4641201 A22025-10-293791P06213Espacenet
JP 2025529142 A2025-09-042120P06213Espacenet
US 12371689 B22025-07-292120P06213Espacenet
JP 2025517969 A2025-06-123791P06213Espacenet
JP 2025517970 A2025-06-124237P06213Espacenet

Drugs 31

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BMS-754807CHEMBL575448Insulin receptor inhibitorINHIBITORChEMBL
INSULIN ASPARTCHEMBL1201496Insulin receptor agonistAGONISTChEMBL
INSULIN ASPART PROTAMINE RECOMBINANTCHEMBL1201664Insulin receptor agonistAGONISTChEMBL
INSULIN DEGLUDECCHEMBL2107869Insulin receptor agonistAGONISTChEMBL
INSULIN DETEMIRCHEMBL2104391Insulin receptor agonistAGONISTChEMBL
INSULIN GLARGINECHEMBL1201497Insulin receptor agonistAGONISTChEMBL
INSULIN GLULISINECHEMBL1201613Insulin receptor agonistAGONISTChEMBL
INSULIN HUMANCHEMBL1201631Insulin receptor agonistAGONISTChEMBL
INSULIN HUMAN ZINCCHEMBL2108974Insulin receptor agonistAGONISTChEMBL
INSULIN HUMAN, ISOPHANECHEMBL2108973Insulin receptor agonistAGONISTChEMBL

Trials 1844

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07582471INSULIN HUMANClinicalTrials.gov
NCT07560150INSULIN ASPARTPHASE2/PHASE3ClinicalTrials.gov
NCT07540975INSULIN HUMANClinicalTrials.gov
NCT07535827INSULIN HUMANEARLY_PHASE1ClinicalTrials.gov
NCT07527078INSULIN DEGLUDECPHASE3ClinicalTrials.gov
NCT07501533INSULIN HUMANPHASE2ClinicalTrials.gov
NCT07485101INSULIN HUMANClinicalTrials.gov
NCT07461103INSULIN GLARGINEPHASE2ClinicalTrials.gov
NCT07461103INSULIN HUMANPHASE2ClinicalTrials.gov
NCT07432581INSULIN HUMANClinicalTrials.gov

NIH grants 11713

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK036836Diabetes Research Center1432,025NIH's project files
P30CA016672Cancer Center Support Grant882,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)742,025NIH's project files
P30CA008748Cancer Center Support Grant642,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award402,025NIH's project files
P30DK063491Diabetes Research Center (DRC)332,025NIH's project files
P30DK056341Washington University Nutrition Obesity Research Center302,025NIH's project files
R01AA011431FASD Inhibition of ASPH-Notch Mediates Adolescent Cerebral White Matter Pathology-Potential Utility of Non-invasive Extracellular Vesicle Assays302,025NIH's project files
R01DK067536Role of IGF-1 and insulin receptors beta-cell survival302,025NIH's project files
P30DK017047Diabetes Research Center272,025NIH's project files

Papers 28269

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826791PubTator, text miningPubMed
42825299PubTator, text miningPubMed
42817866PubTator, text miningPubMed
42808200PubTator, text miningPubMed
42803630PubTator, text miningPubMed
42797057PubTator, text miningPubMed
42783754PubTator, text miningPubMed
42780728PubTator, text miningPubMed
42779891PubTator, text miningPubMed
42779755PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license