ConductScience.org, home

Library / Genes

IRAK1: interleukin 1 receptor associated kinase 1

1 protein, 75 patents, 2 drugs, 42 trials, 3,913 NIH grants and 7,221 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIRAK1HGNC
Nameinterleukin 1 receptor associated kinase 1HGNC
NCBI Gene ID3654NCBI Gene
HGNC IDHGNC:6112HGNC
EnsemblENSG00000184216NCBI Gene
AliasesIRAK, pelleNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P51617Interleukin-1 receptor-associated kinase 17121Ensembl, GeneID, HGNCUniProt

Patents 75

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-198700P51617Espacenet
EP 4640849 A22025-10-291318P51617Espacenet
EP 4641201 A22025-10-298891P51617Espacenet
JP 2025519096 A2025-06-241318P51617Espacenet
JP 2025517969 A2025-06-128891P51617Espacenet
JP 2025517970 A2025-06-128700P51617Espacenet
JP 2024123008 A2024-09-106697P51617Espacenet
US 11708396 B22023-07-251733P51617Espacenet
US 11701385 B22023-07-18110P51617Espacenet
US 11446398 B22022-09-2041702P51617Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
PACRITINIBCHEMBL2035187Interleukin-1 receptor-associated kinase 1 inhibitorINHIBITORChEMBL
PACRITINIB CITRATECHEMBL5095049Interleukin-1 receptor-associated kinase 1 inhibitorINHIBITORChEMBL

Trials 42

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07447817PACRITINIBPHASE2ClinicalTrials.gov
NCT07394153PACRITINIBPHASE2ClinicalTrials.gov
NCT07387354PACRITINIBPHASE1/PHASE2ClinicalTrials.gov
NCT07226713PACRITINIBPHASE2ClinicalTrials.gov
NCT07148947PACRITINIBPHASE2ClinicalTrials.gov
NCT07033598PACRITINIBPHASE2ClinicalTrials.gov
NCT06986174PACRITINIBPHASE2ClinicalTrials.gov
NCT06782373PACRITINIBPHASE2ClinicalTrials.gov
NCT06675123PACRITINIBPHASE1ClinicalTrials.gov
NCT06538181PACRITINIBPHASE1ClinicalTrials.gov

NIH grants 3913

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant312,025NIH's project files
P30DK034854Integrated Epithelial and Muscosal Biology152,025NIH's project files
P30CA008748Cancer Center Support Grant132,025NIH's project files
R01AI024717Genetic Linkage in Lupus112,025NIH's project files
ZIABC011008Oncogenic mechanisms and molecular targets in lymphoma92,025NIH's project files
P30DK034989Yale Liver Center82,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)72,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award72,025NIH's project files
ZIAAG000393Influence of Post-transcriptional Gene Regulation on Cell Senescence and Aging72,025NIH's project files
P01CA019014Viral Oncogenesis, Latency, and Replication62,025NIH's project files

Papers 7221

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42793211PubTator, text miningPubMed
42791244PubTator, text miningPubMed
42767380PubTator, text miningPubMed
42758243PubTator, text miningPubMed
42755754PubTator, text miningPubMed
42741641PubTator, text miningPubMed
42736272PubTator, text miningPubMed
42732946PubTator, text miningPubMed
42719581PubTator, text miningPubMed
42705471PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license