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Gene · 3656

IRAK2: interleukin 1 receptor associated kinase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IRAK2: interleukin 1 receptor associated kinase 2. Genes, record 3656. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3656

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Gene

Symbol
IRAK2
HGNC
Name
interleukin 1 receptor associated kinase 2
HGNC
NCBI Gene ID
3656
NCBI Gene
HGNC ID
HGNC:6113
HGNC
Ensembl
ENSG00000134070
NCBI Gene
Aliases
IDAAI, IRAK-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43187Interleukin-1 receptor-associated kinase-like 26251Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450286O43187Espacenet
EP 4641202 A22025-10-294480O43187Espacenet
JP 2025032204 A2025-03-1130040O43187Espacenet
KR 1020250017231 A2025-02-044480O43187Espacenet
EP 4461818 A22024-11-1330040O43187Espacenet
US 11708396 B22023-07-251737O43187Espacenet
JP 2023058610 A2023-04-2530040O43187Espacenet
US 11446398 B22022-09-2041714O43187Espacenet
JP 2022524081 A2022-04-27144685O43187Espacenet
US 11078247 B22021-08-035568O43187Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,100

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIRAK2 papersNewest fiscal year
P30DK034854Integrated Epithelial and Muscosal Biology62025
P30CA014236Cancer Center Support Grant (CCSG)42025
P30CA016672Cancer Center Support Grant42025
UL1TR001863Yale Clinical and Translational Science Award42025
P30CA016056Roswell Park Cancer Center Support Grant32025
R01AI080607Studies in Poxvirus Host Range Genes and Tropism32025
P30AR075043University of Michigan Skin Biology and Diseases Resource-based Center22025
P30CA008748Cancer Center Support Grant22025
P30CA091842Cancer Center Support Grant22025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)22025

1 to 10 of 1,100Source NIH's project files

See all 1,100 nih grants

Papers1,409

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
660 nm photobiomodulation attenuates inflammatory-catabolic transcriptional programs in an osteoarthritis-like cellular model.J Photochem Photobiol B202642732763PubTator, text miningPubMed
When less is more: loss of IRAK2 signalling promotes inflammation.Nat Rev Rheumatol202642547809PubTator, text miningPubMed
Application of NanoString Technologies in Chronic Myeloid Leukemia, Essential Thrombocythemia, Primary Myelofibrosis, and Polycythemia Vera: A Pilot Study.Diagnostics (Basel)202642279591PubTator, text miningPubMed
IRAK2 deficiency causes immune dysregulation through defective Myddosome assembly and enhanced interferon responses.Nat Commun202642168171PubTator, text miningPubMed
Chlorpromazine activates cGAS-STING signaling and reprograms the immune response in glioblastoma.Front Immunol202641782888PubTator, text miningPubMed
Integrated transcriptomics and molecular docking identify hub genes and statin regulators in Helicobacter pylori-associated gastric mucosal pathogenesis.Front Cell Infect Microbiol202641769350PubTator, text miningPubMed
Single-Cell Transcriptomic Profile Associated with Sub-Subtype A6 and CRF63-02A6 HIV-1 Strain Infection.Viruses202641754547PubTator, text miningPubMed
Cytokines and Chemokines as Emerging Biomarkers and Therapeutic Targets in Colorectal Cancer-Narrative Review.Int J Mol Sci202641752132PubTator, text miningPubMed
Integrated Single-Cell Multi-Omics Analysis Reveals That a CD8+ TPex-Monocyte Interaction Axis Coordinates Immune Infiltration in Alzheimer's Disease.Int J Mol Sci202641751920PubTator, text miningPubMed
TRIM26 deficiency drives gastric cancer lymph node metastasis via TGF-β signaling activation and modulates gemcitabine response.Front Cell Dev Biol202641727323PubTator, text miningPubMed

1 to 10 of 1,409

See all 1,409 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3656

GET https://conductscience.org/api/genes/v1/3656/patents?page=2