Gene · 3656
IRAK2: interleukin 1 receptor associated kinase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IRAK2: interleukin 1 receptor associated kinase 2. Genes, record 3656. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3656
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43187 | Interleukin-1 receptor-associated kinase-like 2 | 625 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents31
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 50286 | O43187 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4480 | O43187 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 30040 | O43187 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4480 | O43187 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 30040 | O43187 | Espacenet |
| US 11708396 B2 | 2023-07-25 | 1737 | O43187 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 30040 | O43187 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 41714 | O43187 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 144685 | O43187 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 5568 | O43187 | Espacenet |
1 to 10 of 31
See all 31 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,100
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IRAK2 papers | Newest fiscal year |
|---|---|---|---|
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 6 | 2025 |
| P30CA014236 | Cancer Center Support Grant (CCSG) | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 4 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 3 | 2025 |
| R01AI080607 | Studies in Poxvirus Host Range Genes and Tropism | 3 | 2025 |
| P30AR075043 | University of Michigan Skin Biology and Diseases Resource-based Center | 2 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30CA091842 | Cancer Center Support Grant | 2 | 2025 |
| P30DK040561 | Boston Area Nutrition Obesity Research Center (NORC) | 2 | 2025 |
1 to 10 of 1,100Source NIH's project files
See all 1,100 nih grantsPapers1,409
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| 660 nm photobiomodulation attenuates inflammatory-catabolic transcriptional programs in an osteoarthritis-like cellular model. | J Photochem Photobiol B | 2026 | 42732763 | PubTator, text mining | PubMed |
| When less is more: loss of IRAK2 signalling promotes inflammation. | Nat Rev Rheumatol | 2026 | 42547809 | PubTator, text mining | PubMed |
| Application of NanoString Technologies in Chronic Myeloid Leukemia, Essential Thrombocythemia, Primary Myelofibrosis, and Polycythemia Vera: A Pilot Study. | Diagnostics (Basel) | 2026 | 42279591 | PubTator, text mining | PubMed |
| IRAK2 deficiency causes immune dysregulation through defective Myddosome assembly and enhanced interferon responses. | Nat Commun | 2026 | 42168171 | PubTator, text mining | PubMed |
| Chlorpromazine activates cGAS-STING signaling and reprograms the immune response in glioblastoma. | Front Immunol | 2026 | 41782888 | PubTator, text mining | PubMed |
| Integrated transcriptomics and molecular docking identify hub genes and statin regulators in Helicobacter pylori-associated gastric mucosal pathogenesis. | Front Cell Infect Microbiol | 2026 | 41769350 | PubTator, text mining | PubMed |
| Single-Cell Transcriptomic Profile Associated with Sub-Subtype A6 and CRF63-02A6 HIV-1 Strain Infection. | Viruses | 2026 | 41754547 | PubTator, text mining | PubMed |
| Cytokines and Chemokines as Emerging Biomarkers and Therapeutic Targets in Colorectal Cancer-Narrative Review. | Int J Mol Sci | 2026 | 41752132 | PubTator, text mining | PubMed |
| Integrated Single-Cell Multi-Omics Analysis Reveals That a CD8+ TPex-Monocyte Interaction Axis Coordinates Immune Infiltration in Alzheimer's Disease. | Int J Mol Sci | 2026 | 41751920 | PubTator, text mining | PubMed |
| TRIM26 deficiency drives gastric cancer lymph node metastasis via TGF-β signaling activation and modulates gemcitabine response. | Front Cell Dev Biol | 2026 | 41727323 | PubTator, text mining | PubMed |
1 to 10 of 1,409
See all 1,409 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3656
GET https://conductscience.org/api/genes/v1/3656/patents?page=2