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IRF1: interferon regulatory factor 1

1 protein, 89 patents, 0 drugs, 0 trials, 7,049 NIH grants and 11,089 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIRF1HGNC
Nameinterferon regulatory factor 1HGNC
NCBI Gene ID3659NCBI Gene
HGNC IDHGNC:6116HGNC
EnsemblENSG00000125347NCBI Gene
AliasesIMD117, IRF-1, MARNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P10914Interferon regulatory factor 13250Ensembl, GeneID, HGNCUniProt

Patents 89

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026042782 A2026-02-268P10914Espacenet
EP 4698657 A22026-02-25383P10914Espacenet
EP 4650780 A22025-11-191150P10914Espacenet
JP 2025147176 A2025-10-0615169P10914Espacenet
JP 2025517970 A2025-06-121150P10914Espacenet
KR 1020250067969 A2025-05-1532P10914Espacenet
JP 2025506185 A2025-03-0741P10914Espacenet
JP 2025028160 A2025-02-2815169P10914Espacenet
KR 1020250010750 A2025-01-2115169P10914Espacenet
EP 4479067 A22024-12-2541P10914Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 7049

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant432,025NIH's project files
P30CA008748Cancer Center Support Grant382,025NIH's project files
R01AI124346Innate immune signaling and stress response222,025NIH's project files
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation222,025NIH's project files
R01AI046712Activation of Macrophages in Human Autoimmune Diseases202,025NIH's project files
R01AR050401Cytokine Balance in Rheumatoid Arthritis192,025NIH's project files
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital182,025NIH's project files
R01AI044938Inhibition of STAT3 and inflammatory cytokine production182,025NIH's project files
R01AR046713Cytokine regulation of RA synoviocyte phenotype182,025NIH's project files
P30CA047904Cancer Center Support Grant172,025NIH's project files

Papers 11089

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823185PubTator, text miningPubMed
42820287PubTator, text miningPubMed
42811115PubTator, text miningPubMed
42776018PubTator, text miningPubMed
42762927PubTator, text miningPubMed
42750620PubTator, text miningPubMed
42747967PubTator, text miningPubMed
42746249PubTator, text miningPubMed
42738421PubTator, text miningPubMed
42734476PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license