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Gene · 3660

IRF2: interferon regulatory factor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IRF2: interferon regulatory factor 2. Genes, record 3660. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3660

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Gene

Symbol
IRF2
HGNC
Name
interferon regulatory factor 2
HGNC
NCBI Gene ID
3660
NCBI Gene
HGNC ID
HGNC:6117
HGNC
Ensembl
ENSG00000168310
NCBI Gene
Aliases
IRF-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P14316Interferon regulatory factor 23491Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450057P14316Espacenet
EP 4650780 A22025-11-1911044P14316Espacenet
EP 4641201 A22025-10-2911473P14316Espacenet
JP 2025147176 A2025-10-0615170P14316Espacenet
JP 2025517969 A2025-06-1211473P14316Espacenet
JP 2025517970 A2025-06-1211044P14316Espacenet
JP 2025506185 A2025-03-0736P14316Espacenet
JP 2025028160 A2025-02-2815170P14316Espacenet
KR 1020250010750 A2025-01-2115170P14316Espacenet
EP 4479067 A22024-12-2536P14316Espacenet

1 to 10 of 39

See all 39 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,791

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIRF2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant202025
P30AG017265USC/UCLA Center on Biodemography and Population Health92025
ZIAHD001310Gene Regulation In The Immune System72025
P01CA019014Viral Oncogenesis, Latency, and Replication62025
P30CA008748Cancer Center Support Grant62025
R01AI124346Innate immune signaling and stress response62025
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation62025
U19AI089992Immune signatures of vaccine responses in vulnerable populations62025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant52025
T32CA009621Surgical Oncology Basic Science and Translational Research Training Program52025

1 to 10 of 1,791Source NIH's project files

See all 1,791 nih grants

Papers2,395

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: The Study of Muscle, Mobility and Aging.Arthritis Rheumatol202642750572PubTator, text miningPubMed
A neuron-distributed DEK integrates ac4C modification and neuroinflammation in pathogenesis of Parkinson disease: evidence from Mendelian randomization, multi-omics and in vitro validation.Front Neurosci202642745872PubTator, text miningPubMed
Deciphering HPV-Associated Immune Evasion in Cervical Cancer Through Multi-Omics Profiling and Computational Screening.Anal Cell Pathol (Amst)202642635083PubTator, text miningPubMed
Regulatory role of IRF2 in proliferation and invasion of nasopharyngeal carcinoma and its underlying mechanism.iScience202642541166PubTator, text miningPubMed
Orthogonal CRISPR screens and human liver chimeric mice identify hepatitis B virus host factors.bioRxiv202642539305PubTator, text miningPubMed
Patient-derived organoid-immune co-cultures integrated with multi-omics reveal immunotherapy resistance mechanisms in urothelial carcinoma.Imeta202642491341PubTator, text miningPubMed
Integrative single-cell and spatial transcriptomics combined with machine learning to discover complement-associated biomarkers in temporal lobe epilepsy with hippocampal sclerosis.Funct Integr Genomics202642458112PubTator, text miningPubMed
In search of dependencies in myeloma, consider IRF2 too.Blood202642348229PubTator, text miningPubMed
The role of interferon regulatory factors in atherosclerosis: from cell type-specific mechanisms to therapeutic strategies.Front Cell Dev Biol202642343899PubTator, text miningPubMed
The paradox of action: Trajectories in distress, meaning, and gene regulation following self-directed activist engagement among Black women.SSM Ment Health202642312185PubTator, text miningPubMed

1 to 10 of 2,395

See all 2,395 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3660

GET https://conductscience.org/api/genes/v1/3660/patents?page=2