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IRF3: interferon regulatory factor 3

1 protein, 76 patents, 0 drugs, 0 trials, 7,949 NIH grants and 16,213 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIRF3HGNC
Nameinterferon regulatory factor 3HGNC
NCBI Gene ID3661NCBI Gene
HGNC IDHGNC:6118HGNC
EnsemblENSG00000126456NCBI Gene
AliasesIIAE7NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q14653Interferon regulatory factor 342718Ensembl, GeneID, HGNCUniProt

Patents 76

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026058346 A2026-04-03312Q14653Espacenet
JP 2026021469 A2026-02-10312Q14653Espacenet
US 12539325 B22026-02-0369Q14653Espacenet
JP 2026004568 A2026-01-1450062Q14653Espacenet
JP 2026004568 A2026-01-1450064Q14653Espacenet
WO 2025260013 A12025-12-1810Q14653Espacenet
EP 4650780 A22025-11-194669Q14653Espacenet
EP 4640849 A22025-10-29629Q14653Espacenet
EP 4641201 A22025-10-294235Q14653Espacenet
JP 2025147176 A2025-10-0615171Q14653Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 7949

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant392,025NIH's project files
P30CA016672Cancer Center Support Grant332,025NIH's project files
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success262,025NIH's project files
P30CA016086Cancer Center Support Grant232,025NIH's project files
P30CA047904Cancer Center Support Grant222,025NIH's project files
P01CA019014Viral Oncogenesis, Latency, and Replication192,025NIH's project files
P30DK034854Integrated Epithelial and Muscosal Biology192,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award172,025NIH's project files
P01AI063302The intersection of innate and adaptive immunity to intracellular pathogens162,025NIH's project files
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital152,025NIH's project files

Papers 16213

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42815867PubTator, text miningPubMed
42815864PubTator, text miningPubMed
42811260PubTator, text miningPubMed
42798494PubTator, text miningPubMed
42797788PubTator, text miningPubMed
42791263PubTator, text miningPubMed
42785749PubTator, text miningPubMed
42785451PubTator, text miningPubMed
42785431PubTator, text miningPubMed
42784634PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license