Gene · 3664
IRF6: interferon regulatory factor 6
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IRF6: interferon regulatory factor 6. Genes, record 3664. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3664
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O14896 | Interferon regulatory factor 6 | 467 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents22
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 50071 | O14896 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8150 | O14896 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1235 | O14896 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8312 | O14896 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15174 | O14896 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 1235 | O14896 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8312 | O14896 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8150 | O14896 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15174 | O14896 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15174 | O14896 | Espacenet |
1 to 10 of 22
See all 22 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,402
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IRF6 papers | Newest fiscal year |
|---|---|---|---|
| P30ES005605 | Environmental Health Sciences Research Center | 11 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| T90DE023520 | University of Iowa Institutional Training Program in Oral Health Research | 6 | 2025 |
| R90DE024296 | University of Iowa Institutional Training Program in Oral Health Research | 5 | 2025 |
| P30DK040561 | Boston Area Nutrition Obesity Research Center (NORC) | 4 | 2025 |
| R01LM012806 | Predicting Phenotype by Deep Learning Heterogeneous Multi-Omics Data | 4 | 2025 |
| I01BX001409 | REGULATORS OF EPITHELIAL TUMOR PROGRESSION | 3 | 2025 |
| P01CA022443 | Molecular Biology and Genetics of Human Tumor Viruses | 3 | 2025 |
| P30AG066511 | Goizueta Alzheimer's Disease Research Center | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,402Source NIH's project files
See all 1,402 nih grantsPapers2,069
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Trio-based GWAS reveals loci associated with different forms of isolated cleft lip. | HGG Adv | 2026 | 42723286 | PubTator, text mining | PubMed |
| Next-Generation Sequencing Data and Clinical Features in Patients with Cleft Palate and Tooth Agenesis: A Systematic Literature Review. | Dent J (Basel) | 2026 | 42645443 | PubTator, text mining | PubMed |
| Enzymatically Hydrolyzed Eggshell Membrane Promotes Keratinocyte Differentiation Associated With PKC and Akt Signaling Pathways. | J Food Sci | 2026 | 42644214 | PubTator, text mining | PubMed |
| A systematic analysis of IBD GWAS loci identifies most probable causal genes impacting intestinal epithelial functions. | medRxiv | 2026 | 42619980 | PubTator, text mining | PubMed |
| Penicophenone F from an Arctic Fungus Against UVB-Induced Corneal Damage via Inhibiting the ROS-EphA2 Pathway. | Antioxidants (Basel) | 2026 | 42510552 | PubTator, text mining | PubMed |
| Genetic and Molecular Basis of Cleft Lip and Palate: A Comprehensive Review. | Diagnostics (Basel) | 2026 | 42510133 | PubTator, text mining | PubMed |
| Deep Phenotyping and Molecular Elucidation of a New Syndrome: Ectodermal Dysplasia Caused by IRF6 Variants. | Exp Dermatol | 2026 | 42487474 | PubTator, text mining | PubMed |
| Retraction of the Research Article "IRF6 and TAK1 coordinately promote the activation of HIPK2 to stimulate apoptosis during palate fusion". | Sci Signal | 2026 | 42447214 | PubTator, text mining | PubMed |
| Evidence that disruption of Discoidin domain receptor 2 contributes to palate malformations through effects on the extracellular matrix. | Hum Mol Genet | 2026 | 42323896 | PubTator, text mining | PubMed |
| Systems-level analysis identifies IRF6 as an inhibitor of epithelial-mesenchymal transition. | J Biol Eng | 2026 | 42289748 | PubTator, text mining | PubMed |
1 to 10 of 2,069
See all 2,069 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3664
GET https://conductscience.org/api/genes/v1/3664/patents?page=2