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Gene · 3664

IRF6: interferon regulatory factor 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IRF6: interferon regulatory factor 6. Genes, record 3664. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3664

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Gene

Symbol
IRF6
HGNC
Name
interferon regulatory factor 6
HGNC
NCBI Gene ID
3664
NCBI Gene
HGNC ID
HGNC:6121
HGNC
Ensembl
ENSG00000117595
NCBI Gene
Aliases
ECTD19, LPS, OFC6, PIT, PPS, PPS1, VWS, VWS1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14896Interferon regulatory factor 64670Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450071O14896Espacenet
EP 4650780 A22025-11-198150O14896Espacenet
EP 4640849 A22025-10-291235O14896Espacenet
EP 4641201 A22025-10-298312O14896Espacenet
JP 2025147176 A2025-10-0615174O14896Espacenet
JP 2025519096 A2025-06-241235O14896Espacenet
JP 2025517969 A2025-06-128312O14896Espacenet
JP 2025517970 A2025-06-128150O14896Espacenet
JP 2025028160 A2025-02-2815174O14896Espacenet
KR 1020250010750 A2025-01-2115174O14896Espacenet

1 to 10 of 22

See all 22 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,402

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIRF6 papersNewest fiscal year
P30ES005605Environmental Health Sciences Research Center112025
P30CA016672Cancer Center Support Grant62025
T90DE023520University of Iowa Institutional Training Program in Oral Health Research62025
R90DE024296University of Iowa Institutional Training Program in Oral Health Research52025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)42025
R01LM012806Predicting Phenotype by Deep Learning Heterogeneous Multi-Omics Data42025
I01BX001409REGULATORS OF EPITHELIAL TUMOR PROGRESSION32025
P01CA022443Molecular Biology and Genetics of Human Tumor Viruses32025
P30AG066511Goizueta Alzheimer's Disease Research Center32025
P30CA008748Cancer Center Support Grant32025

1 to 10 of 1,402Source NIH's project files

See all 1,402 nih grants

Papers2,069

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Trio-based GWAS reveals loci associated with different forms of isolated cleft lip.HGG Adv202642723286PubTator, text miningPubMed
Next-Generation Sequencing Data and Clinical Features in Patients with Cleft Palate and Tooth Agenesis: A Systematic Literature Review.Dent J (Basel)202642645443PubTator, text miningPubMed
Enzymatically Hydrolyzed Eggshell Membrane Promotes Keratinocyte Differentiation Associated With PKC and Akt Signaling Pathways.J Food Sci202642644214PubTator, text miningPubMed
A systematic analysis of IBD GWAS loci identifies most probable causal genes impacting intestinal epithelial functions.medRxiv202642619980PubTator, text miningPubMed
Penicophenone F from an Arctic Fungus Against UVB-Induced Corneal Damage via Inhibiting the ROS-EphA2 Pathway.Antioxidants (Basel)202642510552PubTator, text miningPubMed
Genetic and Molecular Basis of Cleft Lip and Palate: A Comprehensive Review.Diagnostics (Basel)202642510133PubTator, text miningPubMed
Deep Phenotyping and Molecular Elucidation of a New Syndrome: Ectodermal Dysplasia Caused by IRF6 Variants.Exp Dermatol202642487474PubTator, text miningPubMed
Retraction of the Research Article "IRF6 and TAK1 coordinately promote the activation of HIPK2 to stimulate apoptosis during palate fusion".Sci Signal202642447214PubTator, text miningPubMed
Evidence that disruption of Discoidin domain receptor 2 contributes to palate malformations through effects on the extracellular matrix.Hum Mol Genet202642323896PubTator, text miningPubMed
Systems-level analysis identifies IRF6 as an inhibitor of epithelial-mesenchymal transition.J Biol Eng202642289748PubTator, text miningPubMed

1 to 10 of 2,069

See all 2,069 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3664

GET https://conductscience.org/api/genes/v1/3664/patents?page=2