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IRS1: insulin receptor substrate 1

1 protein, 117 patents, 1 drug, 1 trial, 7,008 NIH grants and 14,719 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIRS1HGNC
Nameinsulin receptor substrate 1HGNC
NCBI Gene ID3667NCBI Gene
HGNC IDHGNC:6125HGNC
EnsemblENSG00000169047NCBI Gene
AliasesHIRS-1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P35568Insulin receptor substrate 11,2428Ensembl, GeneID, HGNCUniProt

Patents 117

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4667578 A22025-12-24205P35568Espacenet
EP 4650780 A22025-11-194313P35568Espacenet
EP 4641201 A22025-10-293852P35568Espacenet
JP 2025157475 A2025-10-1551P35568Espacenet
JP 2025131621 A2025-09-09205P35568Espacenet
JP 2025517969 A2025-06-123852P35568Espacenet
JP 2025517970 A2025-06-124313P35568Espacenet
JP 2024123008 A2024-09-106559P35568Espacenet
US 11892452 B22024-02-0676P35568Espacenet
US 11708396 B22023-07-251738P35568Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AGANIRSENCHEMBL2108296Insulin receptor substrate 1 mRNA antisense inhibitorANTISENSE INHIBITORChEMBL

Trials 1

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07386743AGANIRSENPHASE3ClinicalTrials.gov

NIH grants 7008

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant922,025NIH's project files
P30DK036836Diabetes Research Center822,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)522,025NIH's project files
P30CA008748Cancer Center Support Grant332,025NIH's project files
P30DK063491Diabetes Research Center (DRC)302,025NIH's project files
ZIAAG000975ALZHEIMERS RESEARCH PROJECT / CLINICAL PROJECT: Mechanistic and clinical studies in Alzheimer's disease and related disorders272,025NIH's project files
P30CA068485Cancer Center Support Grant232,025NIH's project files
P30DK020541NYR-Diabetes Research Center (NYR-DRC)232,025NIH's project files
P30DK072476Pennington/Louisiana NORC182,025NIH's project files
R01AA011431FASD Inhibition of ASPH-Notch Mediates Adolescent Cerebral White Matter Pathology-Potential Utility of Non-invasive Extracellular Vesicle Assays182,025NIH's project files

Papers 14719

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818069PubTator, text miningPubMed
42801824PubTator, text miningPubMed
42800535PubTator, text miningPubMed
42794563PubTator, text miningPubMed
42794492PubTator, text miningPubMed
42792733PubTator, text miningPubMed
42789558PubTator, text miningPubMed
42789384PubTator, text miningPubMed
42789062PubTator, text miningPubMed
42785104PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license