Gene · 3670
ISL1: ISL LIM homeobox 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ISL1: ISL LIM homeobox 1. Genes, record 3670. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3670
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P61371 | Insulin gene enhancer protein ISL-1 | 349 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents63
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4805378 A1 | 2026-09-16 | 703 | P61371 | Espacenet |
| WO 2026048797 A | 2026-03-05 | 18 | P61371 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 50415 | P61371 | Espacenet |
| JP 2025184866 A | 2025-12-18 | 15 | P61371 | Espacenet |
| JP 2025184866 A | 2025-12-18 | 17 | P61371 | Espacenet |
| WO 2025248252 A1 | 2025-12-04 | 16 | P61371 | Espacenet |
| WO 2025248252 A1 | 2025-12-04 | 17 | P61371 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15184 | P61371 | Espacenet |
| US 12285543 B2 | 2025-04-29 | 3 | P61371 | Espacenet |
| US 12285543 B2 | 2025-04-29 | 6 | P61371 | Espacenet |
1 to 10 of 63
See all 63 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants3,140
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ISL1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 24 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 13 | 2025 |
| P30DK020593 | Vanderbilt Diabetes Research Center | 10 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 9 | 2025 |
| R01HL113006 | Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling | 9 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 8 | 2025 |
| R01HL057181 | Cardiogenesis: Molecular Mechanisms | 8 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| P30DK019525 | University of Pennsylvania Diabetes Research Center | 7 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 7 | 2025 |
1 to 10 of 3,140Source NIH's project files
See all 3,140 nih grantsPapers3,753
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Establishment of a human pluripotent stem cell-derived sensory neuron platform for studying diabetes-associated metabolic and oxidative stress-induced neuronal injury. | J Neurosci Methods | 2027 | 42826868 | PubTator, text mining | PubMed |
| Variation in enhancer activity across brain regions defines neurological disease risk and shapes cellular pathology. | bioRxiv | 2026 | 42817952 | PubTator, text mining | PubMed |
| Paedomorphic Patterns of Gene Expression in the Eyes of Brook Salamanders. | Integr Comp Biol | 2026 | 42747168 | PubTator, text mining | PubMed |
| Comprehensive Clinicopathologic, Immunohistochemical, and Genomic Profiling of Sporadic Ampullary Somatostatin-producing D-cell Neuroendocrine Tumors Identifies Recurrent HRAS Hotspot Mutations. | Endocr Pathol | 2026 | 42730891 | PubTator, text mining | PubMed |
| TRANsCre-DIONE transdifferentiates scar-forming reactive astrocytes into functional motor neurons. | Exp Mol Med | 2026 | 42722703 | PubTator, text mining | PubMed |
Neuroendocrine Differentiation in Synovial Sarcoma-An Immunohistochemical Study of 357 Tumors With 4 Markers: Chromogranin A, Synaptophysin, Insulinoma-associated Protein 1 and Insulin Gene Enhancer Protein ISL-1. | Appl Immunohistochem Mol Morphol | 2026 | 42720542 | PubTator, text mining | PubMed |
| Exercise-associated epigenetic remodeling and TCR repertoire dynamics in Lynch syndrome carriers. | iScience | 2026 | 42701426 | PubTator, text mining | PubMed |
| Conserved neuronal-like and secretory programs define the spatial architecture of gastroenteropancreatic neuroendocrine tumors. | J Clin Invest | 2026 | 42678737 | PubTator, text mining | PubMed |
| Direct neuronal reprogramming for neurological diseases: applications, translational Challenges, and future directions. | Front Neurosci | 2026 | 42630431 | PubTator, text mining | PubMed |
| Human iPSC-Derived Spinal Cord Organoids - The First Electrophysiological Assessment of Neuronal Maturation. | ACS Chem Neurosci | 2026 | 42615637 | PubTator, text mining | PubMed |
1 to 10 of 3,753
See all 3,753 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3670
GET https://conductscience.org/api/genes/v1/3670/patents?page=2