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Gene · 3670

ISL1: ISL LIM homeobox 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ISL1: ISL LIM homeobox 1. Genes, record 3670. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3670

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Gene

Symbol
ISL1
HGNC
Name
ISL LIM homeobox 1
HGNC
NCBI Gene ID
3670
NCBI Gene
HGNC ID
HGNC:6132
HGNC
Ensembl
ENSG00000016082
NCBI Gene
Aliases
ISLET1, Isl-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P61371Insulin gene enhancer protein ISL-13490Ensembl, GeneID, HGNC

Source UniProt

Patents63

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4805378 A12026-09-16703P61371Espacenet
WO 2026048797 A2026-03-0518P61371Espacenet
JP 2026004568 A2026-01-1450415P61371Espacenet
JP 2025184866 A2025-12-1815P61371Espacenet
JP 2025184866 A2025-12-1817P61371Espacenet
WO 2025248252 A12025-12-0416P61371Espacenet
WO 2025248252 A12025-12-0417P61371Espacenet
JP 2025147176 A2025-10-0615184P61371Espacenet
US 12285543 B22025-04-293P61371Espacenet
US 12285543 B22025-04-296P61371Espacenet

1 to 10 of 63

See all 63 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants3,140

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleISL1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant242025
P30CA086862Cancer Center Support Grant132025
P30DK020593Vanderbilt Diabetes Research Center102025
P30DK058404Molecular and Cellular Basis for Digestive Diseases92025
R01HL113006Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling92025
P30CA068485Cancer Center Support Grant82025
R01HL057181Cardiogenesis: Molecular Mechanisms82025
P30CA016672Cancer Center Support Grant72025
P30DK019525University of Pennsylvania Diabetes Research Center72025
UL1TR001863Yale Clinical and Translational Science Award72025

1 to 10 of 3,140Source NIH's project files

See all 3,140 nih grants

Papers3,753

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Establishment of a human pluripotent stem cell-derived sensory neuron platform for studying diabetes-associated metabolic and oxidative stress-induced neuronal injury.J Neurosci Methods202742826868PubTator, text miningPubMed
Variation in enhancer activity across brain regions defines neurological disease risk and shapes cellular pathology.bioRxiv202642817952PubTator, text miningPubMed
Paedomorphic Patterns of Gene Expression in the Eyes of Brook Salamanders.Integr Comp Biol202642747168PubTator, text miningPubMed
Comprehensive Clinicopathologic, Immunohistochemical, and Genomic Profiling of Sporadic Ampullary Somatostatin-producing D-cell Neuroendocrine Tumors Identifies Recurrent HRAS Hotspot Mutations.Endocr Pathol202642730891PubTator, text miningPubMed
TRANsCre-DIONE transdifferentiates scar-forming reactive astrocytes into functional motor neurons.Exp Mol Med202642722703PubTator, text miningPubMed
Neuroendocrine Differentiation in Synovial Sarcoma-An Immunohistochemical Study of 357 Tumors With 4 Markers: Chromogranin A, Synaptophysin, Insulinoma-associated Protein 1 and Insulin Gene Enhancer Protein ISL-1.
Appl Immunohistochem Mol Morphol202642720542PubTator, text miningPubMed
Exercise-associated epigenetic remodeling and TCR repertoire dynamics in Lynch syndrome carriers.iScience202642701426PubTator, text miningPubMed
Conserved neuronal-like and secretory programs define the spatial architecture of gastroenteropancreatic neuroendocrine tumors.J Clin Invest202642678737PubTator, text miningPubMed
Direct neuronal reprogramming for neurological diseases: applications, translational Challenges, and future directions.Front Neurosci202642630431PubTator, text miningPubMed
Human iPSC-Derived Spinal Cord Organoids - The First Electrophysiological Assessment of Neuronal Maturation.ACS Chem Neurosci202642615637PubTator, text miningPubMed

1 to 10 of 3,753

See all 3,753 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3670

GET https://conductscience.org/api/genes/v1/3670/patents?page=2