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ITGA2B: integrin subunit alpha 2b

1 protein, 50 patents, 6 drugs, 69 trials, 3,948 NIH grants and 9,231 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolITGA2BHGNC
Nameintegrin subunit alpha 2bHGNC
NCBI Gene ID3674NCBI Gene
HGNC IDHGNC:6138HGNC
EnsemblENSG00000005961NCBI Gene
AliasesBDPLT16, BDPLT2, CD41, CD41B, FMAIT2, GP2B, GPIIb, GT, GT1, GTA, HPA3, PPP1R93NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P08514Integrin alpha-IIb1,03979Ensembl, GeneID, HGNCUniProt

Patents 50

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449966P08514Espacenet
EP 4650780 A22025-11-192065P08514Espacenet
WO 2025228986 A12025-11-0631P08514Espacenet
EP 4644537 A12025-11-0531P08514Espacenet
EP 4641201 A22025-10-291627P08514Espacenet
EP 4641202 A22025-10-29101P08514Espacenet
EP 4641203 A22025-10-2964P08514Espacenet
JP 2025529142 A2025-09-042134P08514Espacenet
KR 1020250117602 A2025-08-058P08514Espacenet
US 12371689 B22025-07-292134P08514Espacenet

Drugs 6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABCIXIMABCHEMBL1201584Integrin alpha-IIb/beta-3 inhibitorINHIBITORChEMBL
EPTIFIBATIDECHEMBL1174Integrin alpha-IIb/beta-3 inhibitorINHIBITORChEMBL
TADOCIZUMABCHEMBL1743076Integrin alpha-IIb/beta-3 antagonistANTAGONISTChEMBL
TIROFIBANCHEMBL916Integrin alpha-IIb/beta-3 inhibitorINHIBITORChEMBL
TIROFIBAN HYDROCHLORIDECHEMBL3189072Integrin alpha-IIb/beta-3 inhibitorINHIBITORChEMBL
ZALUNFIBANCHEMBL3114577Integrin alpha-IIb/beta-3 inhibitorINHIBITORChEMBL

Trials 69

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07537933TIROFIBANPHASE3ClinicalTrials.gov
NCT07493577TIROFIBANPHASE1/PHASE2ClinicalTrials.gov
NCT07347626EPTIFIBATIDEPHASE3ClinicalTrials.gov
NCT07335107TIROFIBANPHASE3ClinicalTrials.gov
NCT07111806TIROFIBANPHASE3ClinicalTrials.gov
NCT06265051TIROFIBANPHASE2/PHASE3ClinicalTrials.gov
NCT06045156TIROFIBANClinicalTrials.gov
NCT06037889TIROFIBANPHASE3ClinicalTrials.gov
NCT05728333TIROFIBANPHASE2/PHASE3ClinicalTrials.gov
NCT05604638TIROFIBAN HYDROCHLORIDEPHASE3ClinicalTrials.gov

NIH grants 3948

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant282,025NIH's project files
P30CA008748Cancer Center Support Grant242,025NIH's project files
R01HL019278Platelet Integrin AlphaIIbBeta3 Structure, Activation, and Ligand Binding: Fibrinogen, Fibrin, D-dimer, and von Willebrand Factor222,025NIH's project files
P01CA108671Myeloproliferative Neoplasms-Research Consortium162,025NIH's project files
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI152,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award132,025NIH's project files
R01EY010843Regulation of Retinal cGMP-Phosphodiesterases102,025NIH's project files
I01CX001696Platelet Reprogramming During Inflammation92,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center92,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant72,025NIH's project files

Papers 9231

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824130PubTator, text miningPubMed
42814899PubTator, text miningPubMed
42803182PubTator, text miningPubMed
42743859PubTator, text miningPubMed
42736061PubTator, text miningPubMed
42708771PubTator, text miningPubMed
42679530PubTator, text miningPubMed
42667018PubTator, text miningPubMed
42649293PubTator, text miningPubMed
42644495PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license