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ITGA4: integrin subunit alpha 4

1 protein, 173 patents, 7 drugs, 196 trials, 4,327 NIH grants and 6,615 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolITGA4HGNC
Nameintegrin subunit alpha 4HGNC
NCBI Gene ID3676NCBI Gene
HGNC IDHGNC:6140HGNC
EnsemblENSG00000115232NCBI Gene
AliasesCD49D, CD49d, IA4NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P13612Integrin alpha-41,0327Ensembl, GeneID, HGNCUniProt

Patents 173

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026019692 A22026-01-22577P13612Espacenet
WO 2025259600 A22025-12-1881P13612Espacenet
EP 4650780 A22025-11-1911440P13612Espacenet
WO 2025228986 A12025-11-064P13612Espacenet
EP 4644537 A12025-11-054P13612Espacenet
EP 4641201 A22025-10-2911979P13612Espacenet
JP 2025147176 A2025-10-067248P13612Espacenet
WO 2025202279 A12025-10-022P13612Espacenet
JP 2025529142 A2025-09-042136P13612Espacenet
JP 2025529142 A2025-09-046774P13612Espacenet

Drugs 7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABRILUMABCHEMBL3137351Integrin alpha-4/beta-7 inhibitorINHIBITORChEMBL
FIRATEGRASTCHEMBL2104967Integrin alpha-4/beta-1 antagonistANTAGONISTChEMBL
FIRATEGRASTCHEMBL2104967Integrin alpha-4/beta-7 antagonistANTAGONISTChEMBL
NATALIZUMABCHEMBL1201607Integrin alpha-4/beta-1 inhibitorINHIBITORChEMBL
NATALIZUMABCHEMBL1201607Integrin alpha-4/beta-7 inhibitorINHIBITORChEMBL
UCB-1184197CHEMBL4297363Integrin alpha-4 inhibitorINHIBITORChEMBL
VEDOLIZUMABCHEMBL1743087Integrin alpha-4/beta-7 inhibitorINHIBITORChEMBL

Trials 196

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07495644VEDOLIZUMABClinicalTrials.gov
NCT07442045VEDOLIZUMABClinicalTrials.gov
NCT07398586VEDOLIZUMABPHASE4ClinicalTrials.gov
NCT07273760VEDOLIZUMABClinicalTrials.gov
NCT07123350VEDOLIZUMABClinicalTrials.gov
NCT06962020VEDOLIZUMABClinicalTrials.gov
NCT06961435VEDOLIZUMABClinicalTrials.gov
NCT06880744VEDOLIZUMABPHASE3ClinicalTrials.gov
NCT06873711VEDOLIZUMABClinicalTrials.gov
NCT06856135VEDOLIZUMABClinicalTrials.gov

NIH grants 4327

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant332,025NIH's project files
P51OD011092Support for National Primate Research Center332,025NIH's project files
P51OD011132Emory National Primate Research Center242,025NIH's project files
P30AI064518Center for AIDS Research202,025NIH's project files
P30AI050409Center for AIDS Research at Emory University192,025NIH's project files
P30CA008748Cancer Center Support Grant192,025NIH's project files
P51OD011104Tulane National Primate Research Center192,025NIH's project files
P30AI027763UCSF-Bay Area Center for AIDS Research172,025NIH's project files
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro162,025NIH's project files
UM1AI068618HIV Vaccine Trials Network Laboratory Center142,025NIH's project files

Papers 6615

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42805448PubTator, text miningPubMed
42729953PubTator, text miningPubMed
42714077PubTator, text miningPubMed
42694954PubTator, text miningPubMed
42692375PubTator, text miningPubMed
42663992PubTator, text miningPubMed
42650926PubTator, text miningPubMed
42639058PubTator, text miningPubMed
42627827PubTator, text miningPubMed
42558353PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license