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ITGA5: integrin subunit alpha 5

1 protein, 90 patents, 3 drugs, 12 trials, 2,927 NIH grants and 5,748 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolITGA5HGNC
Nameintegrin subunit alpha 5HGNC
NCBI Gene ID3678NCBI Gene
HGNC IDHGNC:6141HGNC
EnsemblENSG00000161638NCBI Gene
AliasesCD49e, FNRA, VLA-5, VLA5ANCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P08648Integrin alpha-51,04916Ensembl, GeneID, HGNCUniProt

Patents 90

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-193528P08648Espacenet
EP 4641201 A22025-10-293109P08648Espacenet
EP 4641202 A22025-10-29184P08648Espacenet
JP 2025531671 A2025-09-2510P08648Espacenet
EP 4615516 A12025-09-171P08648Espacenet
JP 2025529142 A2025-09-042137P08648Espacenet
US 12371689 B22025-07-292137P08648Espacenet
EP 4573186 A12025-06-2510P08648Espacenet
JP 2025517969 A2025-06-123109P08648Espacenet
JP 2025517970 A2025-06-123528P08648Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATN-161CHEMBL4297456Integrin alpha-5/beta-1 antagonistANTAGONISTChEMBL
PF-04605412CHEMBL2109622Fibronectin receptor alpha inhibitorINHIBITORChEMBL
VOLOCIXIMABCHEMBL2108061Integrin alpha-5/beta-1 antagonistANTAGONISTChEMBL

Trials 12

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT00782093VOLOCIXIMABPHASE1ClinicalTrials.gov
NCT00666692VOLOCIXIMABPHASE1ClinicalTrials.gov
NCT00654758VOLOCIXIMABPHASE1ClinicalTrials.gov
NCT00635193VOLOCIXIMABPHASE1/PHASE2ClinicalTrials.gov
NCT00516841VOLOCIXIMABPHASE2ClinicalTrials.gov
NCT00401570VOLOCIXIMABPHASE2ClinicalTrials.gov
NCT00369395VOLOCIXIMABPHASE2ClinicalTrials.gov
NCT00352313ATN-161PHASE1/PHASE2ClinicalTrials.gov
NCT00278187VOLOCIXIMABPHASE2ClinicalTrials.gov
NCT00131651ATN-161PHASE2ClinicalTrials.gov

NIH grants 2927

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant142,025NIH's project files
P30CA008748Cancer Center Support Grant122,025NIH's project files
P30CA016058Cancer Center Support Grant82,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant72,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant72,025NIH's project files
P30CA015704Cancer Center Support Grant62,025NIH's project files
P30CA016087Cancer Center Support Grant62,025NIH's project files
P30CA068485Cancer Center Support Grant62,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases62,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award62,025NIH's project files

Papers 5748

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42807652PubTator, text miningPubMed
42792205PubTator, text miningPubMed
42783701PubTator, text miningPubMed
42731512PubTator, text miningPubMed
42724716PubTator, text miningPubMed
42724607PubTator, text miningPubMed
42697930PubTator, text miningPubMed
42690002PubTator, text miningPubMed
42689980PubTator, text miningPubMed
42659456PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license