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ITGAL: integrin subunit alpha L

1 protein, 71 patents, 4 drugs, 47 trials, 6,118 NIH grants and 12,649 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolITGALHGNC
Nameintegrin subunit alpha LHGNC
NCBI Gene ID3683NCBI Gene
HGNC IDHGNC:6148HGNC
EnsemblENSG00000005844NCBI Gene
AliasesCD11A, EV6, HNA-5, LFA-1, LFA1ANCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P20701Integrin alpha-L1,17041Ensembl, GeneID, HGNCUniProt

Patents 71

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4794715 A12026-08-26169P20701Espacenet
JP 2026004568 A2026-01-1449977P20701Espacenet
EP 4650780 A22025-11-197347P20701Espacenet
EP 4640849 A22025-10-291091P20701Espacenet
EP 4641201 A22025-10-297295P20701Espacenet
JP 2025147176 A2025-10-067256P20701Espacenet
JP 2025529142 A2025-09-042144P20701Espacenet
JP 2025529142 A2025-09-046776P20701Espacenet
US 12371689 B22025-07-292144P20701Espacenet
US 12371689 B22025-07-296776P20701Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EFALIZUMABCHEMBL1201575Integrin alpha-L/beta-2 (LFA-1) inhibitorINHIBITORChEMBL
LIFITEGRASTCHEMBL2048028Integrin alpha-L/beta-2 (LFA-1) antagonistANTAGONISTChEMBL
ODULIMOMABCHEMBL2109177Leukocyte adhesion glycoprotein LFA-1 alpha inhibitorINHIBITORChEMBL
ROVELIZUMABCHEMBL2109224Integrin alpha-L/beta-2 (LFA-1) antagonistANTAGONISTChEMBL

Trials 47

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06624384LIFITEGRASTPHASE1ClinicalTrials.gov
NCT05505292LIFITEGRASTPHASE42025-01-14ClinicalTrials.gov
NCT04734197LIFITEGRASTPHASE22025-03-18ClinicalTrials.gov
NCT04669561LIFITEGRASTPHASE4ClinicalTrials.gov
NCT03866629LIFITEGRASTClinicalTrials.gov
NCT03431272LIFITEGRASTPHASE4ClinicalTrials.gov
NCT02284516LIFITEGRASTPHASE32017-03-15ClinicalTrials.gov
NCT01743729LIFITEGRASTPHASE32017-02-24ClinicalTrials.gov
NCT01636206LIFITEGRASTPHASE32016-10-03ClinicalTrials.gov
NCT01421498LIFITEGRASTPHASE32017-02-24ClinicalTrials.gov

NIH grants 6118

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant292,025NIH's project files
P30CA008748Cancer Center Support Grant282,025NIH's project files
T32AI007485Predoctoral Training Program in Immunology182,025NIH's project files
P30CA086862Cancer Center Support Grant162,025NIH's project files
P30CA016058Cancer Center Support Grant142,025NIH's project files
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)132,025NIH's project files
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies112,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase112,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award112,025NIH's project files
P30AI060354Harvard University Center for AIDS Research102,025NIH's project files

Papers 12649

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42799997PubTator, text miningPubMed
42793190PubTator, text miningPubMed
42710178PubTator, text miningPubMed
42678741PubTator, text miningPubMed
42632754PubTator, text miningPubMed
42594169PubTator, text miningPubMed
42582347PubTator, text miningPubMed
42574805PubTator, text miningPubMed
42507679PubTator, text miningPubMed
42491856PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license