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ITGB1: integrin subunit beta 1

1 protein, 294 patents, 6 drugs, 96 trials, 12,328 NIH grants and 29,457 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolITGB1HGNC
Nameintegrin subunit beta 1HGNC
NCBI Gene ID3688NCBI Gene
HGNC IDHGNC:6153HGNC
EnsemblENSG00000150093NCBI Gene
AliasesCD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLABNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P05556Integrin beta-179822Ensembl, GeneID, HGNCUniProt

Patents 294

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026209893 A12026-10-082P05556Espacenet
JP 2026516931 A2026-05-2746P05556Espacenet
JP 2026078491 A2026-05-141P05556Espacenet
WO 2026063308 A2026-03-2624P05556Espacenet
EP 4667578 A22025-12-24262P05556Espacenet
WO 2025259600 A22025-12-1856P05556Espacenet
EP 4650780 A22025-11-194206P05556Espacenet
WO 2025228986 A12025-11-0674P05556Espacenet
EP 4644537 A12025-11-0574P05556Espacenet
EP 4641201 A22025-10-293763P05556Espacenet

Drugs 6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABITUZUMABCHEMBL2109621Integrin alpha-V/beta-1 inhibitorINHIBITORChEMBL
ATN-161CHEMBL4297456Integrin alpha-5/beta-1 antagonistANTAGONISTChEMBL
FIRATEGRASTCHEMBL2104967Integrin alpha-4/beta-1 antagonistANTAGONISTChEMBL
NATALIZUMABCHEMBL1201607Integrin alpha-4/beta-1 inhibitorINHIBITORChEMBL
RG-7594CHEMBL2109649Integrin alpha-V/beta-1 binding agentBINDING AGENTChEMBL
VOLOCIXIMABCHEMBL2108061Integrin alpha-5/beta-1 antagonistANTAGONISTChEMBL

Trials 96

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05925049NATALIZUMABClinicalTrials.gov
NCT05762003NATALIZUMABClinicalTrials.gov
NCT05701423NATALIZUMABClinicalTrials.gov
NCT05618301NATALIZUMABPHASE1ClinicalTrials.gov
NCT05532163NATALIZUMABPHASE4ClinicalTrials.gov
NCT05418010NATALIZUMABPHASE2ClinicalTrials.gov
NCT05304520NATALIZUMABClinicalTrials.gov
NCT05265728NATALIZUMABPHASE32025-11-25ClinicalTrials.gov
NCT05177718NATALIZUMABPHASE42024-04-18ClinicalTrials.gov
NCT04964700NATALIZUMABClinicalTrials.gov

NIH grants 12328

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant922,025NIH's project files
P30CA008748Cancer Center Support Grant422,025NIH's project files
P30CA068485Cancer Center Support Grant342,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases302,025NIH's project files
P30CA093373Cancer Center Support Grant P30282,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center262,025NIH's project files
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant232,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support222,025NIH's project files
P30CA030199Cancer Center Support Grant (CCSG)222,025NIH's project files
P30CA015704Cancer Center Support Grant212,025NIH's project files

Papers 29457

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826447PubTator, text miningPubMed
42819567PubTator, text miningPubMed
42815077PubTator, text miningPubMed
42814290PubTator, text miningPubMed
42803182PubTator, text miningPubMed
42801207PubTator, text miningPubMed
42801008PubTator, text miningPubMed
42799794PubTator, text miningPubMed
42798643PubTator, text miningPubMed
42798452PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license