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ITGB2: integrin subunit beta 2

1 protein, 156 patents, 7 drugs, 47 trials, 6,343 NIH grants and 12,290 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolITGB2HGNC
Nameintegrin subunit beta 2HGNC
NCBI Gene ID3689NCBI Gene
HGNC IDHGNC:6155HGNC
EnsemblENSG00000160255NCBI Gene
AliasesCD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P05107Integrin beta-276929Ensembl, GeneID, HGNCUniProt

Patents 156

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026017877 A12026-01-2222P05107Espacenet
EP 4650780 A22025-11-197135P05107Espacenet
WO 2025228986 A12025-11-0630P05107Espacenet
WO 2025228986 A12025-11-0639P05107Espacenet
WO 2025228986 A12025-11-0667P05107Espacenet
EP 4644537 A12025-11-0530P05107Espacenet
EP 4644537 A12025-11-0539P05107Espacenet
EP 4644537 A12025-11-0567P05107Espacenet
EP 4641201 A22025-10-297041P05107Espacenet
JP 2025147176 A2025-10-067292P05107Espacenet

Drugs 7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EFALIZUMABCHEMBL1201575Integrin alpha-L/beta-2 (LFA-1) inhibitorINHIBITORChEMBL
ERLIZUMABCHEMBL2109095Integrin beta-2 negative modulatorNEGATIVE MODULATORChEMBL
LIFITEGRASTCHEMBL2048028Integrin alpha-L/beta-2 (LFA-1) antagonistANTAGONISTChEMBL
MLN-01CHEMBL2109496Integrin beta-2 inhibitorINHIBITORChEMBL
MLNM-2201CHEMBL2109332Integrin beta-2 inhibitorINHIBITORChEMBL
ROVELIZUMABCHEMBL2109224Integrin alpha-M/beta-2 antagonistANTAGONISTChEMBL
ROVELIZUMABCHEMBL2109224Integrin alpha-L/beta-2 (LFA-1) antagonistANTAGONISTChEMBL

Trials 47

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06624384LIFITEGRASTPHASE1ClinicalTrials.gov
NCT05505292LIFITEGRASTPHASE42025-01-14ClinicalTrials.gov
NCT04734197LIFITEGRASTPHASE22025-03-18ClinicalTrials.gov
NCT04669561LIFITEGRASTPHASE4ClinicalTrials.gov
NCT03866629LIFITEGRASTClinicalTrials.gov
NCT03431272LIFITEGRASTPHASE4ClinicalTrials.gov
NCT02284516LIFITEGRASTPHASE32017-03-15ClinicalTrials.gov
NCT01743729LIFITEGRASTPHASE32017-02-24ClinicalTrials.gov
NCT01636206LIFITEGRASTPHASE32016-10-03ClinicalTrials.gov
NCT01421498LIFITEGRASTPHASE32017-02-24ClinicalTrials.gov

NIH grants 6343

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL063199The role of beta 2 integrins in macrophage fusion262,025NIH's project files
P30CA008748Cancer Center Support Grant232,025NIH's project files
P30CA016672Cancer Center Support Grant182,025NIH's project files
P30CA036727Buffett Cancer Center Support Grant162,025NIH's project files
ZIAAI000646Transgenic Animal Models Of Human Immune Defects152,025NIH's project files
ZIAAI000647Genes And Gene Products As Immunoadjuvants152,025NIH's project files
R01DK079392Intestinal Inflammation: Signaling proteins and the rate of PMN transmigration122,025NIH's project files
R01DK084195Translating oral CD11b agonist as a novel therapeutic for lupus nephritis112,025NIH's project files
R01HL065095Regulators of immune complex mediated neutrophil antigen presentation112,025NIH's project files
U01CA210240Pancreatic Cancer Detection Consortium112,025NIH's project files

Papers 12290

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42816964PubTator, text miningPubMed
42801207PubTator, text miningPubMed
42792898PubTator, text miningPubMed
42746249PubTator, text miningPubMed
42717081PubTator, text miningPubMed
42692375PubTator, text miningPubMed
42687923PubTator, text miningPubMed
42653279PubTator, text miningPubMed
42652231PubTator, text miningPubMed
42652217PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license