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Gene · 369

ARAF: A-Raf proto-oncogene, serine/threonine kinase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ARAF: A-Raf proto-oncogene, serine/threonine kinase. Genes, record 369. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/369

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Gene

Symbol
ARAF
HGNC
Name
A-Raf proto-oncogene, serine/threonine kinase
HGNC
NCBI Gene ID
369
NCBI Gene
HGNC ID
HGNC:646
HGNC
Ensembl
ENSG00000078061
NCBI Gene
Aliases
A-RAF, A-Raf, ARAF1, PKS2, RAFA1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P10398Serine/threonine-protein kinase A-Raf6066Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-199871P10398Espacenet
EP 4641201 A22025-10-2910122P10398Espacenet
JP 2025517969 A2025-06-1210122P10398Espacenet
JP 2025517970 A2025-06-129871P10398Espacenet
JP 2025062604 A2025-04-146011P10398Espacenet
US 11920164 B22024-03-05190P10398Espacenet
US 11564998 B22023-01-316512P10398Espacenet
US 11446398 B22022-09-206011P10398Espacenet
JP 2022524081 A2022-04-27108982P10398Espacenet
US 10463751 B22019-11-056512P10398Espacenet

1 to 10 of 36

See all 36 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BELVARAFENIBCHEMBL3977543RAF serine/threonine protein kinase inhibitorINHIBITORChEMBL
LY-3009120CHEMBL3577124Serine/threonine-protein kinase A-Raf inhibitorINHIBITORChEMBL
TOVORAFENIBCHEMBL3348923RAF serine/threonine protein kinase inhibitorINHIBITORChEMBL

Trials17

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07449754BELVARAFENIBPHASE2ClinicalTrials.gov
NCT07441707TOVORAFENIBPHASE1ClinicalTrials.gov
NCT07206849TOVORAFENIBPHASE2ClinicalTrials.gov
NCT06965114TOVORAFENIBPHASE1/PHASE2ClinicalTrials.gov
NCT06381570TOVORAFENIBEARLY_PHASE1ClinicalTrials.gov
NCT05828069TOVORAFENIBPHASE2ClinicalTrials.gov
NCT05760586TOVORAFENIBClinicalTrials.gov
NCT05566795TOVORAFENIBPHASE3ClinicalTrials.gov
NCT05465174TOVORAFENIBPHASE2ClinicalTrials.gov
NCT04985604TOVORAFENIBPHASE22025-10-02ClinicalTrials.gov

1 to 10 of 17

See all 17 trials

NIH grants1,471

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleARAF papersNewest fiscal year
P30CA008748Cancer Center Support Grant582025
P30CA016672Cancer Center Support Grant382025
P30CA010815Consolidated Basic Cancer Research Program112025
ZIABC010329Regulation of Ras-Dependent Signal Transduction Pathways112025
P30CA076292Moffitt Cancer Center Support Grant102025
P30CA016058Cancer Center Support Grant92025
P30CA016086Cancer Center Support Grant62025
P30GM124165NE-CAT: A Resource for Advanced Macromolecular Crystallography62025
R01CA131261Studying the initiation, progression and therapy of lung cancer in mouse models62025
ZIABC010441Biomolecular Recognition and Binding Mechanisms62025

1 to 10 of 1,471Source NIH's project files

See all 1,471 nih grants

Papers2,279

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
ARAF mutated langerhans cell histiocytosis developed on the background of ARAF/JAK2 mutated polycythaemia vera: evidence of branching evolution from the same progenitor cell. A case report and literature review.
Ann Hematol202642448959PubTator, text miningPubMed
A‑Raf: A serine/threonine protein kinase with important biological functions (Review).Mol Med Rep202642429158PubTator, text miningPubMed
Divergent CRD-dependent mechanisms govern RAS isoform-selective recruitment of CRAF and ARAF.Protein Sci202642423165PubTator, text miningPubMed
ARAF regulates malignant progression of bladder cancer through the p38MAPK pathway.Open Med (Wars)202642205195PubTator, text miningPubMed
Cryo-EM structure and biochemical characterization of a BRAF/CRAF heterodimer: Negative charge in the NtA motif is not required for RAF activation.bioRxiv202642182431PubTator, text miningPubMed
Divergent CRD-Dependent Mechanisms Govern RAS Isoform-Selective Recruitment of CRAF and ARAF.bioRxiv202642182107PubTator, text miningPubMed
Rapid activation of ARF6 after RAF inhibition augments BRAFV600E and promotes therapy resistance.Oncogene202642050077PubTator, text miningPubMed
Multi-omics profiling links enhancer-associated MSH6 downregulation to platinum resistance, prognosis, and immune features in ovarian cancer.Gene202641911956PubTator, text miningPubMed
Solubility based mechanistic profiling of combinatorial drug therapy.Nat Commun202641882025PubTator, text miningPubMed
When Erdheim-Chester Disease Reaches the Pectoral Muscle.Eur J Case Rep Intern Med202641809960PubTator, text miningPubMed

1 to 10 of 2,279

See all 2,279 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/369

GET https://conductscience.org/api/genes/v1/369/patents?page=2