Gene · 369
ARAF: A-Raf proto-oncogene, serine/threonine kinase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ARAF: A-Raf proto-oncogene, serine/threonine kinase. Genes, record 369. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/369
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P10398 | Serine/threonine-protein kinase A-Raf | 606 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents36
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 9871 | P10398 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 10122 | P10398 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 10122 | P10398 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 9871 | P10398 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 6011 | P10398 | Espacenet |
| US 11920164 B2 | 2024-03-05 | 190 | P10398 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 6512 | P10398 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 6011 | P10398 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 108982 | P10398 | Espacenet |
| US 10463751 B2 | 2019-11-05 | 6512 | P10398 | Espacenet |
1 to 10 of 36
See all 36 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials17
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07449754 | BELVARAFENIB | PHASE2 | ClinicalTrials.gov | |
| NCT07441707 | TOVORAFENIB | PHASE1 | ClinicalTrials.gov | |
| NCT07206849 | TOVORAFENIB | PHASE2 | ClinicalTrials.gov | |
| NCT06965114 | TOVORAFENIB | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT06381570 | TOVORAFENIB | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT05828069 | TOVORAFENIB | PHASE2 | ClinicalTrials.gov | |
| NCT05760586 | TOVORAFENIB | ClinicalTrials.gov | ||
| NCT05566795 | TOVORAFENIB | PHASE3 | ClinicalTrials.gov | |
| NCT05465174 | TOVORAFENIB | PHASE2 | ClinicalTrials.gov | |
| NCT04985604 | TOVORAFENIB | PHASE2 | 2025-10-02 | ClinicalTrials.gov |
1 to 10 of 17
See all 17 trialsNIH grants1,471
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ARAF papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 58 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 38 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 11 | 2025 |
| ZIABC010329 | Regulation of Ras-Dependent Signal Transduction Pathways | 11 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 10 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 9 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 6 | 2025 |
| P30GM124165 | NE-CAT: A Resource for Advanced Macromolecular Crystallography | 6 | 2025 |
| R01CA131261 | Studying the initiation, progression and therapy of lung cancer in mouse models | 6 | 2025 |
| ZIABC010441 | Biomolecular Recognition and Binding Mechanisms | 6 | 2025 |
1 to 10 of 1,471Source NIH's project files
See all 1,471 nih grantsPapers2,279
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
ARAF mutated langerhans cell histiocytosis developed on the background of ARAF/JAK2 mutated polycythaemia vera: evidence of branching evolution from the same progenitor cell. A case report and literature review. | Ann Hematol | 2026 | 42448959 | PubTator, text mining | PubMed |
| A‑Raf: A serine/threonine protein kinase with important biological functions (Review). | Mol Med Rep | 2026 | 42429158 | PubTator, text mining | PubMed |
| Divergent CRD-dependent mechanisms govern RAS isoform-selective recruitment of CRAF and ARAF. | Protein Sci | 2026 | 42423165 | PubTator, text mining | PubMed |
| ARAF regulates malignant progression of bladder cancer through the p38MAPK pathway. | Open Med (Wars) | 2026 | 42205195 | PubTator, text mining | PubMed |
| Cryo-EM structure and biochemical characterization of a BRAF/CRAF heterodimer: Negative charge in the NtA motif is not required for RAF activation. | bioRxiv | 2026 | 42182431 | PubTator, text mining | PubMed |
| Divergent CRD-Dependent Mechanisms Govern RAS Isoform-Selective Recruitment of CRAF and ARAF. | bioRxiv | 2026 | 42182107 | PubTator, text mining | PubMed |
| Rapid activation of ARF6 after RAF inhibition augments BRAFV600E and promotes therapy resistance. | Oncogene | 2026 | 42050077 | PubTator, text mining | PubMed |
| Multi-omics profiling links enhancer-associated MSH6 downregulation to platinum resistance, prognosis, and immune features in ovarian cancer. | Gene | 2026 | 41911956 | PubTator, text mining | PubMed |
| Solubility based mechanistic profiling of combinatorial drug therapy. | Nat Commun | 2026 | 41882025 | PubTator, text mining | PubMed |
| When Erdheim-Chester Disease Reaches the Pectoral Muscle. | Eur J Case Rep Intern Med | 2026 | 41809960 | PubTator, text mining | PubMed |
1 to 10 of 2,279
See all 2,279 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/369
GET https://conductscience.org/api/genes/v1/369/patents?page=2