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ITGB3: integrin subunit beta 3

1 protein, 111 patents, 12 drugs, 115 trials, 4,625 NIH grants and 10,383 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolITGB3HGNC
Nameintegrin subunit beta 3HGNC
NCBI Gene ID3690NCBI Gene
HGNC IDHGNC:6156HGNC
EnsemblENSG00000259207NCBI Gene
AliasesBDPLT16, BDPLT2, BDPLT24, CD61, FMAIT1, GP3A, GPIIIa, GT, GT2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P05106Integrin beta-3788123Ensembl, GeneID, HGNCUniProt

Patents 111

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026088136 A2026-05-28341P05106Espacenet
EP 4684799 A22026-01-28341P05106Espacenet
WO 2025259600 A22025-12-1849P05106Espacenet
EP 4650780 A22025-11-1916866P05106Espacenet
WO 2025228986 A12025-11-0633P05106Espacenet
EP 4644537 A12025-11-0533P05106Espacenet
EP 4641201 A22025-10-2920813P05106Espacenet
JP 2025147176 A2025-10-067300P05106Espacenet
JP 2025529142 A2025-09-042150P05106Espacenet
JP 2025529142 A2025-09-046780P05106Espacenet

Drugs 12

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABCIXIMABCHEMBL1201584Integrin alpha-V/beta-3 inhibitorINHIBITORChEMBL
ABCIXIMABCHEMBL1201584Integrin alpha-IIb/beta-3 inhibitorINHIBITORChEMBL
ABITUZUMABCHEMBL2109621Integrin alpha-V/beta-3 inhibitorINHIBITORChEMBL
ATN-161CHEMBL4297456Integrin alpha-V/beta-3 antagonistANTAGONISTChEMBL
CILENGITIDECHEMBL429876Integrin alpha-V/beta-3 antagonistANTAGONISTChEMBL
EPTIFIBATIDECHEMBL1174Integrin alpha-IIb/beta-3 inhibitorINHIBITORChEMBL
ETARACIZUMABCHEMBL5314357Integrin alpha-V/beta-3 antagonistANTAGONISTChEMBL
INTETUMUMABCHEMBL1743032Integrin alpha-V/beta-3 antagonistANTAGONISTChEMBL
TADOCIZUMABCHEMBL1743076Integrin alpha-IIb/beta-3 antagonistANTAGONISTChEMBL
TIROFIBANCHEMBL916Integrin alpha-IIb/beta-3 inhibitorINHIBITORChEMBL

Trials 115

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07537933TIROFIBANPHASE3ClinicalTrials.gov
NCT07493577TIROFIBANPHASE1/PHASE2ClinicalTrials.gov
NCT07347626EPTIFIBATIDEPHASE3ClinicalTrials.gov
NCT07335107TIROFIBANPHASE3ClinicalTrials.gov
NCT07111806TIROFIBANPHASE3ClinicalTrials.gov
NCT06265051TIROFIBANPHASE2/PHASE3ClinicalTrials.gov
NCT06045156TIROFIBANClinicalTrials.gov
NCT06037889TIROFIBANPHASE3ClinicalTrials.gov
NCT05728333TIROFIBANPHASE2/PHASE3ClinicalTrials.gov
NCT05604638TIROFIBAN HYDROCHLORIDEPHASE3ClinicalTrials.gov

NIH grants 4625

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant442,025NIH's project files
P30CA008748Cancer Center Support Grant272,025NIH's project files
P30CA093373Cancer Center Support Grant P30172,025NIH's project files
R01HL019278Platelet Integrin AlphaIIbBeta3 Structure, Activation, and Ligand Binding: Fibrinogen, Fibrin, D-dimer, and von Willebrand Factor152,025NIH's project files
P30CA016087Cancer Center Support Grant122,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant122,025NIH's project files
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro122,025NIH's project files
P30CA030199Cancer Center Support Grant (CCSG)112,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award112,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support102,025NIH's project files

Papers 10383

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824130PubTator, text miningPubMed
42824020PubTator, text miningPubMed
42814899PubTator, text miningPubMed
42808379PubTator, text miningPubMed
42807007PubTator, text miningPubMed
42797298PubTator, text miningPubMed
42781308PubTator, text miningPubMed
42779912PubTator, text miningPubMed
42760591PubTator, text miningPubMed
42758331PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license